Anti arrhythmia Flashcards
1
Q
Class 1a drug examples
A
Procainamide
2
Q
MOA of class 1a
A
- Na+ channel blocker
- decrease conductivity & automaticity
- slow down Phase 0 depolarization rate, lengthen Phase 3 repolarization duration
- ERP increases, APD increases
3
Q
Class 1b examples
A
lidocaine
4
Q
MOA class 1b
A
- Na+ channel blocker
- decrease automaticity
- slow down phase 0 depolarization, shorten phase 3 repolarization
- ERP no change, reduce APD
5
Q
Class 1C
A
Flecainide
6
Q
MOA class 1c
A
- Na+ channel blocker
- decrease automaticity & conductivity
- slow down phase 0 depolarization, shorten phase 3 repolarization
- ERP, APD no change
7
Q
Class 2
A
Metoprolol, propranolol
8
Q
MOA class 2
A
- beta blockers (block B1), eventually blocks Ca2+ channel preventing influx of Ca2+ to induce Ca induced Ca release
- prolong phase 4, no change in shape to rest of the graph
- reduce HR, contractility
- ERP, ADP no change
9
Q
beta blocker contraindications
A
- relative contraindication in asthma
- diabetics
10
Q
Class 1C clinical uses
A
- refractory ventricular tachycardia
11
Q
Class 2 clinical uses
A
- tachycardia (sympathetically activated or AV nodal reentrant)
- atrial fibrillation
- protective for post MI
12
Q
Class 3
A
Amiodarone
13
Q
Class 3 MOA
A
- K+ channel inhibitor (Ikr, Iks)
- prolong phase 3 (so class 3)
- increase ERP, APD
14
Q
name a long term drug (effects maintained for 1-3 months after last dose) and why
A
amiodarone
- liver metabolism -> produce active metabolite desethylamiodarone
15
Q
Class 3 clinical uses
A
- atrial fibrillation
- reentrant tachycardia
