Anti-Angina Drugs (Nitrodilators)

Question 1

What are the 2 common classifications of nitrodilators?

Answer 1

Short-acting nitrates

Long-acting nitrates

Question 2

What are the names of some common short-acting nitrates?

Answer 2

Sublingual nitroglycerin (Nitrostat)
Nitroglycerin Spray (NitroMist)

Question 3

What are the names of some common long-acting nitrates?

Answer 3

Isosorbide dinitrate (Isordil)

Question 4

Which drug is commonly prescribed for Pt.’s with stable angina?

Answer 4

Sublingual nitroglycerin (short-acting)

Question 5

MOA

Answer 5

Form nitric oxide, which leads to smooth muscle relaxation (vasodilation) - prescribed to keep vessels open for as long as possible so that BF is not occluded
Decrease TPR ==> decrease SVR ==> decrease BP ==> decrease stress on heart

Question 6

Indications:

Answer 6

Angina

CHF

Question 7

Common adverse reactions:

Answer 7

Headache
Lightheadedness/syncope
OTN (if vessels overdilated)
need to monitor BP response if Pt. takes it in the clinic bc of chest pain