Anterior and Posterior Pituitary

Question 1

Nonfunctional pituitary tumors classically present as

Answer 1

bitemporal hemianopsia

Question 2

Most common functional anterior pituitary tumor

Answer 2

prolactinoma

women: galactorrhea and amenorrhea
men: loss of libido

Question 3

GH adenoma may cause these conditions

Answer 3

gigantism in children

acromegaly in adults

Question 4

Most common cause of death in gigantism/acromegaly

Answer 4

heart failure

heart and other tissues are also enlarged in this condition

Question 5

Dx of GH adenoma

Answer 5

elevated GH and IGF-1

Question 6

Endocrine complication of GH adenoma

Answer 6

2˚ diabetes mellitus

GH induces gluconeogenesis

Question 7

Tx of GH adenoma that isn’t surgery

Answer 7

octreotide

SS analogue, prevents GHRH from releasing GH

Question 8

Masses that may cause hypopituitarism in
adults
children

Answer 8

adults: pituitary adenoma
children: craniopharyngeoma

Question 9

Sheehan syndrome
etiology
complications
presentation

Answer 9

• caused by massive hemorrhage during delivery 2˚ to fact that pituitary very large in pregnant women but blood supply does not increase at all
• causes panhypopituitarism
• presents as loss of pubic hair and decreased ability to make milk

Question 10

Central diabetes insipidus etiology

Answer 10

ADH deficiency

hypothalamic or pituitary pathology

Question 11

Common drug causing nephrogenic diabetes insipidus

Answer 11

¡¡¡lithium!!!

Question 12

Tx of central diabetes insipidus

Answer 12

desmopressin

vasopressin ie ADH analogue

Question 13

SIADH etiology

Answer 13

ectopic production, either from post pituitary or
paraneoplastic syndrome ie small cell lung cancer
also other pulmonary pathologies ie COPD

Question 14

SIADH is common paraneoplastic syndome of this primary neoplasm

Answer 14

small cell lung cancer

Question 15

Tx of SIADH

Answer 15

demeclocycline