anterior and posterior Flashcards

1
Q

how is the hypothalamus linked to the posterior pituitary

A

a direct link via the magnocellular neurones

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2
Q

how is the hypothalamus linked to the anterior pituitary

A

a circulatory system link where parvicellular neurones secrete regulatory hormones into the bloodstream which travel into the anterior lobe which trigger other hormones

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3
Q

by which system is the hypothalamus and the anterior pituitary linked

A

the hypothalamic-pituitary portal system

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4
Q

name the tropic anterior hormones

A

FSH, LH,Adrenocorticotropic hormone, TSH

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5
Q

name the non tropic anterior hormones

A

Prolactin, Growth hormone

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6
Q

what are the precursors of the tropic anterior hormones

A

Gonadotropin releasing hormone (FSH,LH), Corticotropin releasing hormone (adrenocorticotropic hormone), Thyrotropin releasing hormone (TSH)

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7
Q

what are the precursors of the non tropic anterior hormones

A

prolactin releasing/inhibiting hormone (prolactin), GH releasing/inhibiting hormone

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8
Q

what is the role of the tropins

A

to regulate function of other primary endocrine glands

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9
Q

where is FSH and LH synthesised stored and secreted from

A

the gonadotropes

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10
Q

how do the non tropic hormones act on tissues

A

directly

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11
Q

what is the function of prolactin on the body

A

effects on breast tissue for lactation

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12
Q

treatment of prolactinoma

A

dopamine receptor agonist e.g. bromocriptine

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13
Q

what hormone is overproduced with a prolactinoma

A

prolactin

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14
Q

where is prolactin synthesised stored and secreted

A

lactotropes

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15
Q

where is growth hormone s+S+S

A

somatotropes

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16
Q

what is the effect of growth hormone on the body

A

stimulates growth, cell production and regeneration

17
Q

what are the effects of too much growth hormone in adults and children

A
adults = acromegaly 
children = gigantism
18
Q

treatment for excess GH

A

somatostatin

19
Q

why might a synthetic sandosatin for treatment of excess GH be considered

A

longer half life

20
Q

what is the treatment for too little GH

A

somatropin

21
Q

what are the posterior pituitary hormones

A

oxytocin and vasopressin

22
Q

what is the function of oxytocin

A

stimulates milk ejection and uterine muscle contraction at birth

23
Q

what is the function of vasopressin

A

promotes reabsorption of water

24
Q

moa of vasopressin

A

binds to cells in collecting duct

synthesises and inserts aquaporins into tubule

25
Q

what is diabetes insipidus

A

excessive urine production

26
Q

what is the pathogenesis behind hypothalamic diabetes insipidus

A

a deficiency in vasopressin secretion

27
Q

what can cause hypothalamic diabetes insipidus

A

head trauma

28
Q

how to treat hypothalamic diabetes insipidus

A

exogenous vasopressin

29
Q

what is the pathogenesis of nephrogenic diabetes insipidus

A

kidneys are insensitive to vasopressin

30
Q

what can cause nephrogenic diabetes insipidus

A

kidney disease

31
Q

how to treat nephrogenic diabetes insipidus

A

increasing water consumption