anterior and posterior Flashcards
how is the hypothalamus linked to the posterior pituitary
a direct link via the magnocellular neurones
how is the hypothalamus linked to the anterior pituitary
a circulatory system link where parvicellular neurones secrete regulatory hormones into the bloodstream which travel into the anterior lobe which trigger other hormones
by which system is the hypothalamus and the anterior pituitary linked
the hypothalamic-pituitary portal system
name the tropic anterior hormones
FSH, LH,Adrenocorticotropic hormone, TSH
name the non tropic anterior hormones
Prolactin, Growth hormone
what are the precursors of the tropic anterior hormones
Gonadotropin releasing hormone (FSH,LH), Corticotropin releasing hormone (adrenocorticotropic hormone), Thyrotropin releasing hormone (TSH)
what are the precursors of the non tropic anterior hormones
prolactin releasing/inhibiting hormone (prolactin), GH releasing/inhibiting hormone
what is the role of the tropins
to regulate function of other primary endocrine glands
where is FSH and LH synthesised stored and secreted from
the gonadotropes
how do the non tropic hormones act on tissues
directly
what is the function of prolactin on the body
effects on breast tissue for lactation
treatment of prolactinoma
dopamine receptor agonist e.g. bromocriptine
what hormone is overproduced with a prolactinoma
prolactin
where is prolactin synthesised stored and secreted
lactotropes
where is growth hormone s+S+S
somatotropes
what is the effect of growth hormone on the body
stimulates growth, cell production and regeneration
what are the effects of too much growth hormone in adults and children
adults = acromegaly children = gigantism
treatment for excess GH
somatostatin
why might a synthetic sandosatin for treatment of excess GH be considered
longer half life
what is the treatment for too little GH
somatropin
what are the posterior pituitary hormones
oxytocin and vasopressin
what is the function of oxytocin
stimulates milk ejection and uterine muscle contraction at birth
what is the function of vasopressin
promotes reabsorption of water
moa of vasopressin
binds to cells in collecting duct
synthesises and inserts aquaporins into tubule
what is diabetes insipidus
excessive urine production
what is the pathogenesis behind hypothalamic diabetes insipidus
a deficiency in vasopressin secretion
what can cause hypothalamic diabetes insipidus
head trauma
how to treat hypothalamic diabetes insipidus
exogenous vasopressin
what is the pathogenesis of nephrogenic diabetes insipidus
kidneys are insensitive to vasopressin
what can cause nephrogenic diabetes insipidus
kidney disease
how to treat nephrogenic diabetes insipidus
increasing water consumption
