Antepartum Flashcards
Polysystic ovary syndrome
Treatment
Varies + depends on the degree of infertility and desire for conception
Pcos in obese women has been treated with weight loss programs alone
Hormonal contraceptives to initiate normal orulatory function and suppress the continued physical enlargement
Poly cystic ovary syndrome
S/s
Cause
V406
Affects5% of women. Most common diagnosis implicated in ovarian dysfunction related to infertility
Hyperandrogenism
Menstrual irregularities amenorrhea, oligomen
Physical characteristics: obesity, acne, alopecia, hirsuitism
Often insulin resistant
Cause is unknown
What conditions are associated with the development of oligohydramnios?
Congenital anomalies
IUGR
Postmature syndrome
What is the shortest anteroposterior diameter of the pelvis?
The obstetrical conjugate
Congenital heart disease
Grades 2-4
Why a high risk factor
Increased blood volume and weight puts strain on the heart
Condition requires clinical, radiological surveillance
B/P
Systolic reading
Indicates the pressure in the arteries when the heart is actively pumping
Systolic pressure indicates cardiovascular tolerance for exertion
B/P
Diastolic reading
Indicates the pressure in the arteries when the heart is at rest
Diastolic pressure assesses baseline intravascular tension
MSAFP should be performed between what weeks?
What 3 anomalies could cause a level above normal?
15-20
Neural tube defects
Multiple gestation
Fetal demise
Fetal alcohol syndrome
S/S
Growth problems
Heart defects
Mental retardation
Facial abnormalities
Problems with muscle and nerve development
Less agile/athletic
Trouble with organization, concentration and impulse control
History of PID and effects
Can cause scarring of the uterine lining Predisposes to Ectopic prey Irregular placental implantation 3 rd stage hemorrhage Scar tissue may form at the cervical os
LEEP
Consideration
A laser procedure similar in effect to cone biopsy
Correlated to incomplete cervix and premature labor
Macrocyclic anemias
V 684
Increased red cell size
Vitamin b12 deficiency Folic acid deficiency Hypothyroidism Alcoholism Chronic liver or renal disease
Micro cystic anemias
V684
Decreased Rbc and size
Iron deficiency anemia Thalalsemias Hemoglobin E disorders Lead toxicity Chronic disease infection neoplasm
Hemolytic anemia
V684
This is a normocytic anemia,where rbc’s are abnormal size
Hemolytic disorders
Sickle cell disease
Hemoglobin c disorders
Acquired medication side effect
Autoimmune
FetL heart rate reactivity is usually reached at what gestational age?
28-32 weeks
What are 3 changes in the cardiac system during pregnancy?
Increase in cardiac volume
Heart displacement to the left
Increase of 10 beats /min in resting heart rate
Complications with polyhydfamnios
Cord prolapse
Placental abruption
Pp hemorrhage
For how long does rho gam provide protection against developing antibodies?
12 weeks
Untreated a symptomatic bacteriuria can cause
Low. Orthodox weight infant
Pyclonephritis
Preterm labor
Which result of a uc bacterial count indicates the presence of a uti?
50,000 bacteria of same species per milliliter of urine
What is the physiological reason for increased chance of uti in pregnancy?
Hydronephrosis which causes urinary stasis
Frequency of SAB after the preg has been clinically diagnosed
1 in 20
Blood volume increases by approximately _____ during pregnancy?
40-45%
Exercise increases all of the following in the preg body?
3 answers
Blood volume
Vascular urge
Cardiac input
Two hormones the placenta produces are
Estrogen and progesterone
Three risk factors for an incompetent cervix?
Previous cervical cone biopsy
History of cervical laceration during a previous childbirth
History of 3 or more abortions using suction
Diabetes
Why is it a high risk factor
Fetal demise after 36 weeks
5x the normal incidences of fetal abnormalities
Increased polyhydramnios
30-50% higher incidence of pre eclampsia
Increased incidence of prematurity and nb respiratory difficulties
Thyroid disease
Why is it a high risk factor
Particularly hyperthyroidism
Dangers
Thyroid medication has potential for causing severe fetal complications
Miscarriage, premature labor, fetal anomalies
Untreated hypothyroidism can lead to cretinism in the newborn
Acute tuberculosis
Why a high risk factor
If under treatment prognosis is god
Baby must be imm. Separated from the mom if she is infectious
Dangers
Slightly higher risk of miscarriage or premature labor
TORCH illnesses
T-toxoplasmosis o- other syphillis, hep b, parvovirus, Epstein Barr and varicella R-rubella C-cytomegalovirus H-herpes simplex virus
Hepatitis A Definition S/S Transmission Treatment Effects on baby
Infectious flu like symptoms
Fecal loran route contaminated water and food
99% require no treatment
No adverse fetal effects of active maternal infection have been identified
Breast feeding is okay
Hepatitis B Def Transmission Screening Effect on baby
Serum hep chronic or carrier state
Transmitted through blood, dirty needle, saliva, vag secretions, semen
Screening blod sample for hbsag
High risk of transmission to NB, who if infected have a high risk of becoming carriers. Should be immunized 12 hrs after birth
Hepatitis B
S/s
Treatment
Abdominal pain, chills, fever
Should be hospitalized and have all family members screened
Not responsive to any treatment and must run its natural course
A person with chronic hep b should be screened for liver disease
Hep b is present in all bodily fluids except
Breast milk
What is the best management of a NB of a hep b infected mother?
Immediate birth,immunization with hep b immune globulin and immunization hep b vaccination
Hepatitis C
Definition
Transmission
Effect on baby
20% of viral hepatitis in USA
Transmission is primarily via blood and blood products but can be a std
Signs of active infection are similar to HBV, but chronic conditions develop in 85% of cases
Perinatal transmission 5% depending on the amount I’d virus in bloodstream
Breast milk not affected
No immunization for hep C
How does hep c effect pregnancy and birth?
The woman will be monitored for signs of abnormal liver disease
That may affect her nutritional status
What kind of viral hepatitis is transmitted via the fetal oral route?
Hep A
Syphilis
Def
Cause/transmission
Effect on fetus
Std
Transmitted through the placenta at any stage of infection 40%with untreated disease have fetal or neonatal loss SAB or stillborn. Another 40% have babies with congenital syphillis
Crippling lesions on internal organs and bones to death
Placenta is large, heavy and a pale yellow gray color
Syphilis
Lab test
Management
Diagnosis lab tests depend on the stage the disease is in, antibody screening,,RPR
Preg should be tested at 1st appt and at 28 weeks, or if she has chlamydia, gonorrhea or hpv
Treatment goal of preventing transmission and preventing progression of disease
Preferred drug for any stage is penicillin
Risks to fetus of treatment ptl, fetal distress, stillbirth, jarisch here helmer reaction
Syphillis
Symptoms
Primary- chancre at site of infection painless heals spontaneously AB response present
Secondary- 4 weeks to 6 months after infection
Rash on palms of hands and soles of feet, hair loss, heals spontaneously in 2-10 weeks
Latent- no manifestations.
Tertiary- 1year-3 years after infection.
High morbidity 1 mortality. 2 forms: gumma: soft tissue tumors, or cardiovascular.
Cytomegalovirus
- def
- cause
- effect on fetus
-fairly common infection- 60% pop. has antibodies
Most damaging in 1st trial
-Member of herpes virus group
- Spread thru contact with bodily fluids, within households, daycare centers, classrooms.
-Fetus at risk if primary infection for mom, usually not recognized until birth.
- 80%-90% will have complications that include hearing loss,vision impairment and varying degrees of mental retardation.
Cytomegalovirus
- SIS in pregnant women
- lab tests
- management plan
- most women have minimal if any symptoms and are unaware of the infection
- symptoms of mononucleosis
- signs of hepatis with negative test results for hepatis A,B,C
- no treatment for CMV infection in healthy persons.
- can be transmitted to the infant through genital secretions / breast milk
Toxoplasmosis
- SIS in the pregnant women
- lab tests
- management plan
- SIS vague, similar to mononucleosis
Fatigue, muscle pain, fever, sore throat,
Enlarged posterior cervical lymph nodes - serum testing for 1gM and 1gG, repeat x3 weeks
-if suspected-
imm. referral for uis to check for fetal anomalies
Amniotic fluid and fetal blood can be sampled to confirm fetal infection
-Tx: can reduce harmful fetal effects
Anti-protozoal drugs
Toxoplasmosis
- cause
- effect on fetus/child
- protozoal infection caused by toxoplasma gondii
- humans are exposed thru exposure to cat feces, infected soil, or ingestion of raw or undercooked meats -> usually pork
- can cause severe congenital malformations because it can cross the placenta. Most severe in 1st trial
- many infants have no SIS at birth, bit can develop: seizures, motor and cognitive definite and mental retardation throughout childhood.
Sickle cell trait / disease and
Implications in the AP
- primary complication is an increase in UTI and hematuria
- can be cared for by a midwife only collaboration with a physician experienced in dealing with sickle cell
How does pregnancy affect the course of sickle cell disease?
Pregnancy increases both the intensity and frequency of sickle cell crises.
Congenital rubella syndrome
Most common malformations: cataracts, cardiac defects, deafness.
May also be:
Glaucorna microcephaly, and other defects involving the eyes ears, heart, brain, and CNS.
Infants with CRS frequently exhibit intrauterine and post natal growth retardation.
In what stage of pregnancy is maternal infection with rubella most likely to cause congenital malformation
In the first month.
Explain the safety of the Rubella vaccine (for a woman 4 weeks pregnant, had vaccine 2 weeks ago)
Explain to the woman that there is a theoretical rick from the vaccine, but there is no demonstrated evidence of teratogenicity for the vaccine.
What is the best course of action when a woman has an active Varicella infection during delivery for the immediate postpartum?
Give VZIG to the infant immediately and consider isolation of infant from mother.
Rubella
-weeks gestation and risk of morbidity
-If contracted during the first trimester, there is a 52% chance the baby will be born with congenital rubella syndrome.
The risk increases to 85% if contracted during the first 8 weeks. Infection after the 20th week rarely causes defects.
Describe the rash of rubella
Pale or bright red, spreading rapidly from face to entire body, and then fading rapidly.
Weeks 17-24
Mother begins to feel movement
Vernix is formed
Lungs are well formed, capillaries develop around already
Hair develops on the head, eyebrows, eyelids, eyes are structurally complete
Weeks 25-28
Subcutaneous fat is laid down Eyes down Lung physiology is sufficiently developed to enable gas exchange to begin Nervous system can control temperature Breathing movements
Week 29
The fetus is fully formed and the organs are able to function to some extent
Week 30 beyond
Organ physiology matures and the fetus continues to lay down fat and muscle
The nervous system continues myelinzation beyond term
Week 6
Liver begins to function Eyes migrate to the front of the face Rudimentary kidneys and genitalia form Cartilage begins to form the skeleton Muscle differentiation begins
Week 5
Rapid brain growth continues
Limb buds appear
Umbilical cord is formed
Heart chambers divided by septa
Week 3-4
The heart begins to pump blood
Brain begins to divide into forebrain, midbrain, hindbrain
Lungs to begin to form
Features of the gi system can be identified
So mites (future vertebrae and muscles) appear to either side of the midline
Days 18-21
The primitive nervous system begins to fold into position
The heart begins to twitch
Primitive eyes and ears begin differentiation
Red blood cells begin development
Day 15
A thick band of cells, the primitive streak appears in the midline of the dorsal surface of the embryo
Blood vessels begin to form
Cell specialization occurs
Day 13 from LMP
Chronic villi begin to secrete hcg, which stimulates the corpus luteum in the ovary to continue producing the hormones necessary to maintain the pregnancy until the placenta is mature enough to take over this role
Physiological effects of estrogen
Development of secondary sex characteristics
Myometrial thickening
Maturation of ovarian follicles
Testosterone production is stimulated by:
Lutenizing hormone
Describe oogenesis
Ongoing differentiate into primary oocytes during early fetal life
The first maturation division results in a secondary oocytes and first polar body
Final maturation of the secondary oocytes is completed at fertilization
Gametogenesis
V. 556
Halving of the chromosomes number is a result of gametogenesis , the process by which mature ova and sperm are developed
Contraction stress test
Checks to see if the fetus will withstand the decrease o2 levels with contractions and placental health EFM Done at 34+ weeks I've pitocin Indicated with abnormal BPP
Define Graafian follicle
f 176
A secondary follicle in the ovary will mature into a vestibular ovarian(Graafian) follicle which is ready for ovulation
Magnesium sulfate is administered primarily to
Decrease neuromuscular irritability
Define the fetal period
From 8 weeks gestation to birth
Parvovirus B19 (Fifth disease, erythema infection) S/s Lab tests Management plan
Flushed red face “slapped cheek pattern”
Before rash
: mild fever, malaise, myalgia a, headache, itchy rash may start on trunk and extremities
Most contagious before symptoms
Diagnosis: parvovirus B19 specific 1gm serum 1gG shows previous infection and immunity
If seroconversion occurs fetus should be checked weekly with u/s for fetal hydrops, placentomegaly, and fetal growth restriction
Parvovirus
Def
Cause
Effect on fetus
Contagious virus common in school children
Transmitted by contact with respiratory secretions or exposure to blood and vertical transmission from mother to fetus
Congenital anomalies not associated with parvovirus
For those fetuses affected some will experience apastic anemia, non immune hydrops and rarely death
Which of the following is an accurate definition of proteinuria
Protein in the urine in excess of 1 g/l
Which change, besides restoration of the diploid number of chromosomes occurs at fertilization
Start of meitotic cell division and fetal sex determination
The largest portion of the uterus is the
Myometrium
Cystic fibrosis, sickle cell anemia, and Tay-Sachs disease, which can be diagnosed by prenatal genetic studies are examples of
Autosomal recessive disorders
The physiological effects of progesterone include
Increased basal metabolism
Placental growth
Development of acini cells in the breasts
Normal values for 1 hr and 3 hr GTT
1 hr 65-139 mg/dl
3 hr fasting 65-95
1 hr 65-180
2 hr 65-155
3 hr 65-140
A rubella titer of greater than 1:64 indicates
Infection
A rubella titer of greater than 1:10 indicates
Immunity
A rubella titer of less than 1:10 indicates
Not immune
Benign ovarian cysts
Most do not require intervention
Commonly asymptomatic
Cysts of significant size cause adnexal motion tenderness or pelvic pain and may grow large enough to cause ovarian torsion
Ox best with u/s
Which of the following demarcations divides the true and false pelvis?
The linea terminalis
Chronic lung disease
Why a high risk factor
Mother at risk for pulmonary complications, baby at risk for fetal acidosis and hypoxia
Severe asthma
Why a high risk factor
Resp infections and stress may intensify attacks
Cardiopulmonary function could be reduced affecting growth and we’ll being
Certain medications used to treat asthma are contraindicated for preg
Epilepsy
Why a high risk
There is controversy over whether or not this condition is exacerbated by preg.
Dangers:
Anticonvulsant drugs may cause Folic acid deficiency which when treated with Folic acid may cause seizures
The infant may develop deficiency of coagulation factors
Renal disease
Why a high risk factor
Impaired kidney function requires close medical surveillance in preg
Signs of renal disease include:
Protein in the urine, hypertension, edema, and elevated blood urea all before the 20th week
Dangers:
Acute adrenal failure
Extreme obesity
Why a high risk factor
Pre existing with a history of medical problems
Nearly 2/3 of extremely obese women have obstetrical implications, including diabetes, hypertension, pyclonephritis, uterine dysfunction, and hemorrhage
Tobacco use
Why a high risk factor
(More than 10 cig daily, although no amount can be considered without risk)
Associated with IUGR, miscarriage, congenital heart disease mad fetal hypoxia during labor
Malnutrition
Why a high risk factor
(Extreme dietary deficiencies- May be substance abuse, debilitating illness, eating disorders)
IUGR p, preeclampsia, maternal or fetal infection, prematurity, still birth, dysfunctional labor, hemorrhage
Tubal pregnancy
S/s
Timing of rupture
Bleeding/spotting
Non rhythmic pain
10-13 weeks.
Normal rate of weight gain
She should gain at least 10lbs by 20 weeks and about 1 lb a week afterwards
Sequential screen
Part 1: 10-12th week blood draw and u/s for unchallenged trans.
Part 2: btw 16-18th week 2nd blood test
Provides risk of having a baby with Down syndrome, trisomy, or neural tube defects
Hugh rate of false positives
Why are yeast infections more common in pregnancy
Yeast tends to overgrow in preg because of increased vaginal alkalinity, which in turn is caused by elevated progesterone levels
Vagina yeast infection
Management
Physiology
Increase of acidity of vaginal canal and extra discharge
-7 day monistat Diflucan No sugar or simple carbs Garlic Tea tree oil
How many days after fertilization is implantation
6 days
When diagnosing preeclampsia what is an accurate definition of hypertension
140/90 + either#
What predisposes a woman to develop preeclampsia
Trophoblastic disease
Maternal age greater than 35
Multiple pregnancy
S/s of preeclampsia
Persistent headaches Visual disturbances Edema Protein urea Increased blood pressure Epigastric pain
Hypermesis gravidarium
Chronic and self perpetuating N+V
So disrupts the electrolyte balance that the woman cannot retain food/ liquid must be restabilized with IV fluids
Emotional underpinnings
Psychological conflicts regarding preg.
History of eating disorders/ body image issues
The heart begins beating in the embryo at (from conception)
___ weeks
3 weeks
5 weeks from LMP
B12
The vegan mother must be careful to ingest adequate ___, without which a serious for of anemia may develop and cause neurological damage to her and her baby
Of the babies whose mothers drank heavily while pregnant, ____% develop FAS
4%
Caffeines effect on the fetus
Elevate fhr
Reduce the amount of fluid and calcium available for baby’s optimal growth
To help prevent leg cramps from disturbing her sleep recommend:
Elevate and support her legs on pillows while sleeping
LAM
Baby must be 6 months or less
After 6 months the woman must find another form of contraception
On demand nursing, at least every 4 hrs during the day and. 6 hrs at night
With a history of gestational diabetes what is a woman’s chance of developing diabetes mellitus in the future
25%