Antenatal care Flashcards
What should women be informed about the additional risk of miscarriage following amniocentesis or CVS?
It is likely to be below 0.5%
What is the earliest gestation amniocentesis should be performed?
15 weeks gestation
What is the earliest gestation CVS should be performed?
10 weeks gestation
What should women be informed about the additional miscarriage risk for twin pregnancy following amniocentesis or CVS?
The additional risk is around 1%
What gestation is CVS usually performed between?
11+0 and 13+6 weeks gestation
1-2% of all CVS results will be affected by which confounding complication?
Combined placental mosaicism
RCOG recommends those trained in CVS and Amniocentesis should carry out how many of these procedure per year as a minimum to maintain skills?
20
Aside from miscarriage, what other risk is increased if amniocentesis is carried out prior to 15 weeks gestation?
Talipes equinovarus
What risks are increased with CVS before 10 weeks?
Oromandibular and limb defects
What complication is increased when amniocentesis is carried out in the third trimester?
Culture failure
Corticosteroids should be offered to women between which gestations when imminent preterm birth is anticipated?
24+0 - 34+6 weeks
What are the two potential harmful side effects of antenatal corticosteroids for the neonate?
Neonatal hypoglycaemia and developmental delay
What is the number needed to treat to prevent 1 neonatal death by giving antenatal corticosteroids between 22-34+6 weeks gestation?
38.5
How should women with multiple pregnancy be counselled about the use of antenatal corticosteroids?
In line with the guidance for singleton pregnancy, however they should be advised of the uncertainties around their use in multiple pregnancy
What is the median latency of delivery after PPROM ?
7 days
What is the change in blood oxygen saturation during a flight at cruising altitude?
SpO2 reduced by 10%
What does the evidence show about risk of adverse pregnancy events with air travel?
There is no good data to suggest an increase in preterm labour, PPROM or abruption
What advice should be given to women about the maximum gestation to fly at?
36 weeks if no complications
32 weeks if any risk factors for preterm birth
Which conditions are absolute contraindications to air flight?
Anaemia with Hb <75
Recent haemorrhage
Otitis media or sinusitis
Serious cardiac or respiratory disease
Recent sickle cell crisis
Recent GI surgery
A fracture
What advice should be given to pregnant women about antimalarial therapy?
Anti-malarials are safe in pregnancy
Which travel vaccines should be avoided in pregnant women?
Live vaccines such as the Yellow Fever vaccine
What percentage of babies born in the UK weigh more than 4,000g?
10%
What is the Number Needed to Treat to prevent 1 fracture by using IOL in LGA?
60
Antepartum haemorrhage is defined as vaginal bleeding after what gestation?
24 weeks
APH complicates what percentage of all pregnancies?
3-5%
What is the definition of minor APH?
Blood loss less than 50mls which has settled
What is the definition of major APH?
Blood loss of 50-1,000mls with no signs of clinical shock
What is the definition of massive APH?
Blood loss greater than 1,000mls and or signs of clinical shock
What is the incidence of recurrent placental abruption?
4.4%
What is the relative risk of placental abruption for women who have first trimester bleeding with an intrauterine haematoma?
Relative Risk 5.6
What is the recurrence rate of placental abruption in women who have had two previous pregnancies complicated by abruption?
19-25%
Approximately what percentage of placental abruptions happen in “low risk” women?
70%
What should be avoided in placenta praevia?
Vaginal and rectal examinations
Penetrative sexual intercourse
What neonatal outcomes are associated with unexplained APH?
Increased risk of preterm birth
Increased rates of IOL
Increased neonatal admission
Increased rates of neonatal hyperbilirubinaema
Decreased birth weight
What should be considered in cases of APH associated with rupture of membranes?
Vasa praevia
What investigation should be performed for Rhesus negative women presenting with APH?
Kleihauer
What is the sensitivity of ultrasound in identifying placental abruption?
24%
Antenatal corticosteroids are associated with a reduction in the risk of… (3)
- Neonatal death
- Respiratory distress syndrome
- Intraventricular haemorrhage
How should antenatal care be changed in a low risk woman with APH from placental abruption or unexplained cause?
- The pregnancy should be reclassified as high risk
- Serial fetal growth scans should be performed
What action should be considered in active APH after 37 weeks?
IOL should be considered to avoid the risk of placental abruption
What advice should be given about fetal monitoring for women with APH?
Women with one episode of minor APH with no subsequent concerns about maternal or fetal wellbeing could have intermittent auscultation
Women with major or recurrent minor APH and those women with suspected abruption should have CEFM
What postnatal plan should be put in place for women with APH?
Recommend active management of the third stage
How should anti-D be managed in Rh negative women with APH after 20 weeks?
500 units Anti-D should be given followed by Kleihauer - if >4mls leak then further anti-D is indicated
Serum lactate above which threshold is indicative of tissue hypoperfusion?
> =4mmol/l
What are the two most common pathogens identified in pregnant women dying of sepsis?
Group A Strep and E.coli
What are the drawbacks of using Co-Amoxiclav to treat maternal sepsis?
- Does not cover MRSA or Pseudomonas
- May cause necrotising enterocolitis in the neonate
When should haemoglobin be rechecked after initiating treatment for anaemia?
After 2 weeks