Antacids, prokinetics, histamine antagonist

Question 1

What happens if you chronically use antacids

Answer 1

SE: chronic use = sm intestine bacterial overgrowth, alkaline urine

Question 2

How particulate antacids work?

Answer 2

↑gastric volume, may not ↑gastric pH, foreign body reaction if aspirated

Question 3

How non-particulate antacids work

Answer 3

more complete mixing, reliable ↑gastric pH, 15-30 ml 15-30 min prior
● MOA: neutralizes acid from gastric contents
● Contraindications: renal dz
Mg = laxative; Al = ↓Ph, ↓Mg, ↑Ca; Ca = ↓Ph, ↑Ca, acid rebound, constipation, gas, met
acid, milk alkali syndrome (↑Ca, ↑BUN/Cr, alkalosis)

Question 4

Prokenetic MOA

Answer 4

MOA: inhibits dopamine, works on 5HT3 receptors = enhances peristaltic contractions & accelerates
gastric emptying

Question 5

Pro kinetic S/E

Answer 5

SE: Inhibits cholinesterase, HoTN, bradycardia, dysrhythmias, akathisias, sedation