ANS - Receptors

Question 1

What are the functional muscarinic receptors?

Answer 1

M1R M2R M3R M4R and M5R are not useful

Question 2

What part of the ANS has muscarinic receptors?

Answer 2

parasympathetic

Question 3

What part of the Ans has nicotinic receptors stimulated by norepinephrine?

Answer 3

sympathetic

Question 4

What does M1R do? What class is it?

Answer 4

Gq-coupled (increase Ca2+) -CNS control (not ANS) -Secretion of salivary glands (increase) -Secretion of Stomach acid (increase KEY: SECRETION

Question 5

What does M2R do? What class is it?

Answer 5

Gi-coupled (decrease cAMP and increase K+ — hyperpolarize) -HEART!!!! -Decrease HR

Question 6

What does M3R do? What class is it?

Answer 6

Gq-coupled (increase Ca2+) CONTRACTION & SECRETION -Smooth muscle contraction -Exocrine secretion

Question 7

What does the alpha-1 adrenergic receptor do? What class is it?

Answer 7

Gq-coupled —– super fight or flight -Vasoconstriction (blood vessels – increase bp) -pupil dilation -lipolysis and glycogenolysis (energy) -decrease tears

Question 8

What does the alpha-2 adrenergic receptor do? What class is it?

Answer 8

• Gi-coupled
• Vasodilation (blood vessels)
• GI relax
• Pancreas (increase glucagon, decrease insulin)
• INCREASED CLOTTING
• Decrease salivation

Question 9

What does the beta-1 adrenergic receptor do? What class is it?

Answer 9

Gs-coupled (increase cAMP and adenylate cyclase)

HEART!!!

• Increase HR
• Inrease force of contraction

Question 10

What does the beta-2 adrenergic receptor do? What class is it?

Answer 10

Gs-coupled

• Brachiodilation
• Smooth muscle relax
• Flattens pupil to see farther/focus

Question 11

What does the beta-3 adrenergic receptor do? What class is it?

Answer 11

Gs-coupled

White fat breakdown (lipolysis)

Brown fat breakdown for thermoregulation