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ANS Pharm Flashcards

1
Q

ANS

What is the mechanism of M1 receptors?

A

Gq- EXCITATORY
PLC –> increased IP3/DAG
Closing K+ channels

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2
Q

ANS

What is the M2 receptor mechanism?

A

Gi- INHIBITORY
Decreased cAMP
Open K+ channels

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3
Q

ANS

What is the M3 receptor mechanism?

A

Gq- EXCITATORY

PLC –> increased IP3/DAG

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4
Q

ANS

What is the action of Hemicholinium?

A

Blocks choline uptake

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5
Q

ANS

The action of Vesamicol?

A

Prevents storage of Ach

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6
Q

ANS

Action of Muscarine?

A

receptor activation

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7
Q

ANS

Action of Atropine?

A

receptor blockade

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8
Q

ANS

Action of Nicotine?

A

receptor activation

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9
Q

ANS

Heart cholinergic impulses

A

SA node:
Rhythm decreased-M2
Contractility decreased-M2

AV node:
conduction decreased-M2
Refractoriness increased-M2

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10
Q

ANS

Lung cholinergic impulses

A

Bronchial muscle contraction-M3

Secretions increased-M3

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11
Q

ANS

Penis cholinergic impulses

A

Boner-M3 (via NO)

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12
Q

ANS

Uterus cholinergic impulses

A

variable-M3

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13
Q

ANS

GIT cholinergic impulses

A

Motility increased-M3
Watery secretion from glands-M3
Gallbladder contraction-M3

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14
Q

ANS

Pancreas cholinergic impulses

A

Exocrine secretion increased-M3

Insulin secretion increased-M

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15
Q

ANS

Urinary bladder cholinergic impulses

A

Detrusor contraction-M3

Sphincter relaxation-M2

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16
Q

ANS

Eye cholinergic impulses

A

Sphincter of iris contraction-M3
Ciliary muscle contraction-M3
Lacrimal gland secretion-M3

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17
Q

ANS

Skin cholinergic impulses

A

Sweat gland secretion-M3

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18
Q

ANS

Autonomic nerve endings

Sympathetic

A

Inhibition of NE release-M2

19
Q

ANS

Autonomic nerve endings

Parasympathetic

A

Inhibition of Ach release-M2

20
Q

ANS

What is the mechanism of Alpha-1 receptor?

A

Gq
PLC–> increased IP3/DAG
PLA2–> eicosanoid synthesis

21
Q

ANS

Mechanism of Alpha-2 receptor?

A

Gi- Decreased cAMP
Gi- Opening of K+ channels
Go- Blockade of Ca2+ channels

22
Q

ANS

Mechanism of Beta-1 receptor?

A

Gs
Increased cAMP
Opening Ca2+ channels

23
Q

ANS

Mechanism of Beta-2 receptor?

A

Gs

Increased cAMP

24
Q

ANS

Mechanism of Beta-3 receptor?

A

Gs

Increased cAMP

25
# ANS Mechanism of D-1 receptor?
Gs | Increased cAMP
26
# ANS Mechanism of D-2 receptor?
Gi- Opening K+ channels | Go- Blockade of Ca2+ channels
27
# ANS Heart adrenergic impulses
SA node- rhythm: Increased rhythm- Beta1 Conduction increased- Beta1 Refractoriness decreased- Beta1 Contractility increased- Beta1 Automaticity increased- Beta1
28
# ANS Arteriole adrenergic impulses
Various organs- constriction- Alpha1 Skeletal muscle dilation- Beta2 Liver dilation- Beta2
29
# ANS Vein adrenergic impulses
Constriction- Alpha1 | Dilation- Beta2
30
# ANS Spleen capsule adrenergic impulses
Spleen capsule contraction- Alpha1
31
# ANS Lung adrenergic impulses
Bronchial muscle relaxation- Beta2 Secretions decreased- Alpha1 Secretions increased- Beta2
32
# ANS Skin adrenergic impulses
Sweat glands- thick secretion- Alpha1
33
# ANS Platelet adrenergic impulses
Aggregation- Alpha2
34
# ANS Mast cells, basophils adrenergic impulses
Inhibition of degranulation- Beta2
35
# ANS Fat cell adrenergic impulses
Increased lipolysis- Beta3
36
# ANS Sex organs adrenergic impulses
Ejaculation- Alpha1 | Uterus relaxation- Beta2
37
# ANS GIT adrenergic impulses
Exocrine glands- thick secretion- Betas | Sphincter contraction- Alpha1
38
# ANS Liver adrenergic impulses
Glycogenolysis increased- Beta2 | Gluconeogenesis increased- Beta2
39
# ANS Pancreas adrenergic impulses
Insulin secretion decreased- Alpha2 | Glucagon secretion increased- Beta2
40
# ANS Adrenergic effect on Kidney
Increased renin secretion- Beta1 | Increased diuresis- D1
41
# ANS Adrenergic effects on Urinary bladder
Trigone and sphincter contraction- Alpha1
42
# ANS Adrenergic effects on Eye
Radial muscle contraction- Alpha1 Increased aqueous humor- Beta2 Decreased aqueous humor- Alpha2
43
# ANS Adrenergic effects on Skeletal muscle
Increased Ca2+ sequestration- Beta2 Increased glycogenolysis- Beta2 Increased K+ uptake- Beta2 **Constant activation can cause tremor**
44
# ANS Adrenergic effects on Autonomic nerve endings
Sympathetic- NE release decreased- Alpha2 NE release increased- Beta2 Parasympathetic- Ach release- Alpha2

Mini 2 Pharm- JOHN (1 decks)

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