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Cardio Week 1 > ANS Drugs Lecture > Flashcards

ANS Drugs Lecture Flashcards

1
Q

What are the Ca2+ channel blockers?

A

“pines”- these block L-type Ca2+ channels in smooth muscle only

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2
Q

What do Diltiazem and Verapamil do?

A

non-dihydropyridine ca2+ channel blockers that block L-type Ca2+ channels in CARDIAC and smooth muscle

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3
Q

Side effects of Ca2+ channel blockers?

A
  • constipation
  • edema
  • bradycardia
  • headache
  • AV block

BEACH

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4
Q

What are some NO releasing drugs?

A
  • Hydralazine

- Nitroprusside

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5
Q

Side effects of Hydralazine?

A
  • reversible lupus like syndrome
  • edema
  • arteriolar dilation

READ

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6
Q

What are some drugs that open K+ channels?

A
  • Minoxidil

- Diazoxide

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7
Q

What is an example of a D1 agonist? Mechanism?

A

Fenoldopam- vasodilates renal vessels and inhibits ACh release

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8
Q

What is a side effect of Diazoxide?

A

you also see inhibition of Ca2+ channels which can decrease insulin secretion and lead to hyperglycemia

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9
Q

How is angiotensinogen converted to angiotension I?

A

renin

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10
Q

What drug blocks renin? Side effect?

A

Alskiren; hyperkalemia

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11
Q

What converts angiotension I to angiotension II?

A

ACE

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12
Q

What else does ACE do?

A

converts bradykinin to inactive metabolites

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13
Q

So what is a side effect of ACE inhibitors?

A

drug, irritating cough

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14
Q

What are the effects of angiotensin II?

A
  • vasoconstriction

- aldosterone secretion

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15
Q

What drugs prevent angiotensin II action?

A

ARBs- angiotension receptor blockers

cough is not a side effect

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16
Q

What are the ACEIs?

A

-end in ‘prils’

17
Q

Side effects of ACEIs?

A
  • cough
  • hyperkalemia
  • angioedema
  • renal damage

CRAH

18
Q

Are ACEIs safe in pregnancy?

A

No, teratogenic

19
Q

What are the ARBs?

A

end in ‘sartan’

20
Q

Side effects of ARBs?

A
  • renal damage in preexisting disease

- hyperkalemia

21
Q

Are ARBs safe in pregnancy?

A

No

22
Q

What are the recommended drugs for HTN in pregnancy?

A

a-methyldopa
Hydralazine

can use Nefidipine, Labetolol, Metoprolol

23
Q

What drugs are contraindicated in pregnancy?

A

ACEIs, ARBs

24
Q

What are the recommended drugs for HTN in diabetes?

A

ACEIs, ARBs

25
Q

What drugs are contraindicated in HTN with diabetes?

A

BB (high dose)

26
Q

What are the recommended drugs for HTN in HF?

A

ACEIs

27
Q

What drugs are contraindicated in HF?

A

BB (high dose), verapamil, diltiazem

28
Q

What are the recommended drugs for HTN in COPD/asthma?

A

CCBs

29
Q

What drugs are contraindicated in COPD/asthma?

A

BBs (non selective high dose), ACEIs

30
Q

What are the recommended drugs for HTN in CKD?

A

ACEIs, ARBs

31
Q

What are the recommended drugs for HTN in BPH?

A

a-blockers

Cardio Week 1 (22 decks)

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