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Neuroscience > ANS drugs > Flashcards

ANS drugs Flashcards

0
Q

Neostigmine

A

indirect acting cholinergic stimulants (AchE inhibitors)

reversible

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1
Q

carbachol

A

direct-acting cholinergic agonist

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2
Q

donepezil

A

indirect acting cholinergic stimulants (AchE inhibitors)

reversible

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3
Q

bethanechol

A

direct-acting cholinergic agonist

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4
Q

edrophonium

A

indirect acting cholinergic stimulants (AchE inhibitors)

reversible

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5
Q

Pilocarpine

A

direct-acting cholinergic agonist

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6
Q

physostigmine

A

indirect acting cholinergic stimulants (AchE inhibitors)

reversible

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7
Q

tacrine

A

indirect acting cholinergic stimulants (AchE inhibitors)

reversible

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8
Q

organophosphates

A

Irreversible indirect acting cholinergic stimulants

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9
Q

Applications of cholinergic stimulants

A 
GI/ urinary bladder atonia
Alzheimer disease
Glaucoma
Myasthenia gravis
Reversal of neuromuscular blockade
Reversal of anticholinergic induced CNS toxicity
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10
Q

atropine

A

anti muscarinic of anticholinergic

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11
Q

anticholinergic drugs side effects

A 
dry mouth
blurred vision
urinary retention
constipation
tachycardia
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12
Q

Clonidine
Uses
adverse effects

A

alpha_2 selective agonist

Teat HTN, anxiety

dizziness, drowsiness, dry mouth

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13
Q

Antimuscarinics applications

A 
pulmonary
cardiovascular
ophthalmology
urinary - decrease smooth muscle tone
GI - decrease muscle tone
CNS: Parkinson, Motion sickness
cholinergic poisoning
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14
Q

phenylephrine
Uses
adverse effects

A

alpha_1 selective agonists

Nasal congestion by decreasing blood flow and secretion

HTN, HA, reflex bradycardia

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15
Q

isoproteronol

Uses

A

non selective beta agonists

Treat bronchospasm

Cautions!! Flushing, angina, arrhythmia

16
Q

Dobutamine

Uses

A

Beta_1 selective agonist

Treat cardiac failure

17
Q

albuterol, salmetrol, ritodine

adverse effects

A

beta_2 selective agonists

Albuterol and salmetrol for asthma
Ritodine for premature labor

nervousness, restlessness, no cardiac side effects because there is no much B2 receptors in hearts

18
Q

prazosin

Uses

A

alpha 1 slective adrenergic antagonist

Treat HTN

19
Q

Epinephrine, Norepineprine

adverse effects

A

non selective mixed alpha, beta adrenergic agonist

excess CNS excitation, excess stimulation of cardiovascular system

20
Q

phentolamine

Uses

A

non-selective alpha adrenergic antagonists

Treat HTN

21
Q

yohimbine

Use

A

alpha 2 selective adrenergic antagonist

Erectile dysfunction

22
Q

propanolol

Adverse effects

A

non-selective beta adrenergic antagonist

Bronchoconstriction, decrease cardiac function too much

Cautions!! Don’t prescribe to patient with pulmonary and respiratory conditions

23
Q

metoprolol

Adverse effects

A

Beta 1 selective adrenergic antagonist

Cardiac selective

Not as much as nonselective b antagonist, there is not much b1 receptors in lung

24
Q

2 types of cholinergic stimulants

A
  1. Direct acting - nicotinic and muscarinic

2. Indirect acting - reversible and irreversible

25
Q

Difference between direct and indirect acting cholinergic stimulants

A

Indirect acting has a relatively low specificity

25
Q

Cholinergic stimulants adverse effects

A

Miosis, urination, bradycardia, bronchoconstriction, lacrimation, excitation of CNS, diarrhea, salivation, sweating

25
Q

2 types of anticholinergics

A

Antimuscarinic

Antinicotinic

26
Q

2 types of antinicotinic

A

Ganglion blockers

NMJ blockers

27
Q

Applications of antimiscarinic

A 
Pulmonary - asthma
Cardivascular
Ophalmology
Urinary - decrease smooth muscle tone
GI - decrease muscle tone
CNS - PD, motion sickness
Cholinergic poisoning
28
Q

2 major classes of adrenergic drugs

A

Sympathomimetics

Sympatholytics - inhibit SNS

29
Q

2 types of adrenergic agonists

A

Direct acting - alpha, beta, mixed agonists

Indirect acting - releasers, reuptake blockers

30
Q

Tizanidine
Uses
Adverse effects

A

Alpha 2 selective agonist

Treat spasticity

Dizziness, drowsiness and dry mouth

31
Q

2 types of adrenergic antagonists

A

Alpha and beta blockers

32
Q

Adverse effects of non selective alpha and alpha 1 antagonists

A

Reflex tachycardia

33
Q

Uses of B and B1 antagonists

A

Cardiac condition - angina, HTN, arrhythmia

Neuroscience (6 decks)

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