ANS Drug Receptors

Question 1

Norepinephrine

Answer 1

Catecholamine

A1~A2 > B1&raquo_space; B2

Question 2

Epinephrine

Answer 2

Catecholamine

B1~B2 > A1~A2

Question 3

Dopamine

Answer 3

Catecholamine

D1=D2&raquo_space; B1&raquo_space; A1

Question 4

Isoproterenol

Answer 4

Catecholamine

B1~B2&raquo_space;> A

Question 5

Dobutamine

Answer 5

B-agonist

B1 > B2

Question 6

Albuterol

Answer 6

“Selective” B2-agonist

B2&raquo_space; B1&raquo_space;> A

Question 7

Terbutaline

Answer 7

“Selective” B2-agonist

B2&raquo_space; B1&raquo_space;> A

Question 8

Ritodrine

Answer 8

“Selective” B2-agonist

B2&raquo_space; B1&raquo_space;> A

Question 9

Phenylephrine

Answer 9

Selective A1-agonist

A1 > A2&raquo_space;> B

Question 10

Midodrinel

Answer 10

Selective A1-agonist
A1 > A2&raquo_space;> B
(prodrug)

Question 11

Clonidine

Answer 11

Centrally acting A2-agonist
A2 > A1&raquo_space;> B
+ imidazoline I1

Question 12

Methyldopa

Answer 12

Centrally acting A2-agonist
A2 > A1&raquo_space;> B
(prodrug –> A-methyl-norepinephrine)

Question 13

Amphetamine

Answer 13

Indirect acting sympathomimetic
uptake 1, no A or B
(cause release of catecholamine from presynaptic cytosolic pool - NE in periphery, NE + DA in CNS)

Question 14

Ephedrine

Answer 14

Indirect acting sympathomimetic
uptake 1, + direct stim of A + B
(cause release of catecholamine from presynaptic cytosolic pool - NE in periphery, NE + DA in CNS)

Question 15

Phenoxybenzamine

Answer 15

Non selective A-antagonist

A1~A2&raquo_space;» B

Question 16

Phentolamine

Answer 16

Non selective A-antagonist

A1=A2&raquo_space;» B

Question 17

Prazosin

Answer 17

A-1 selective A-antagonist
A1&raquo_space;» A2, no B
(terazosin + doxazosin)
A1A ~ A1B ~ A1D