ANS- Cardiovascular Flashcards
what is Cleviprex
Clevidipine
Clevidipine
class/ categorie, uses
Class/Category: Dihydropyridine Calcium-Channel Blocker
Uses: HTN
Clevidipine
MOA
Calcium-Channel Blocker: Inhibits Ca2+ influx into cardiac muscle and vascular smooth muscle
Clevidipine
onset, peak, duration
Onset: 1-3 min
Peak: 2-10 min
Duration: 5-15 min
Clevidipine
metabolism
plasma esterases
clevidipine
CV effects
↓ BP, ↑ HR, ↓ SVR, ↔ preload, ↓ afterload, ↓/↔ inotropy
May experience reflex tachycardia or baroreceptor reflex
Clevidipine
CNS effects
- May ↑ CBF, moderate cerebral vasodilator
- CO2 reactivity maintained
- HA
Clevidipine contraindications
Allergy to soybeans, soy, eggs, or egg products; defective lipid metabolism
Clevidipine relative contrainidations
1
severe aortic stenosis
What conditions should you avoid using clevidipine for
3
- Avoid in heart failure with reduced EF,
- hyperlipidemic states,
- acute or chronic pancreatitis
Does clevidipine cause tachyphylaxis OR rebound HTN
NO, not associated with tachyphylaxis or rebound HTN upon stopping
clevidipine effect on renal blood flow
Increases renal blood flow
What condition prolongs the effects of clevidipine?
Effect prolonged if pseudocholinesterase deficiency
what is EmerPhed
Ephedrine
Ephedrine
class/ category
Synthetic/Non-Catecholamine Adrenergic Agonist; Sympathomimetic
Ephedrine
use
Treatment of hypotension
Ephedrine
MOA
Adrenergic Agonist: Indirect >Direct effects (α1, β1, and β2)
Ephedrine
dose
5-25 mg IV in 5-10 mg incremental doses
Ephedrine
onset, peak, duration
Onset: <1 min
Peak: 2-5 min
Duration: 10-60 min
Ephedrine
elimination
renal
Ephedrine
CV effects
- ↑ BP, ↑ HR, ↑ CO
- ↑ SVR may be offset by β2-induced vasodilation
- ↑ myocardial O2 consumption
Ephedrine
Pulm effects
Bronchodilation (β2)
Ephedrine
CNS effects
- Crosses BBB, CNS excitation
- Mydriasis
What does ephedrine do to renal and splanchnic blood flow?
Decreases renal and splanchnic blood flow