ANS Flashcards

1
Q

ANS Parasymp fibers?

Release what neurotrans?

A

Long pre-gang from cranial and sacral:
release ACh

Short post-gang near organ:
release ACh

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2
Q

ANS Symp fibers?

Release what neurotrans?

A

Short pre-gang in thoracic and lumbar:
release ACh

Long post-gang at target:
release NE

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3
Q

ACh released by which fibers? (5)

A
All pre-gang
Parasymp post-gang
Symp to sweat glands
At adrenal medulla
Somatic to mm
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4
Q

Norepi released by which fibers?

A

Symp post-gang (except sweat glands)

Adrenal medulla

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5
Q

Dopamine released by?

A

renal vasculature

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6
Q

5 steps in neurotrans fxn?

A

1) synthesis
2) storage
3) release
4) receptor interaction
5) inactivation

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7
Q

ACh made how?

A

Choline + Acetyl CoA -> ChAT enz -> ACh

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8
Q

ACh inactivated by?

A

acetylchoninesterase

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9
Q

Adrenergic (epi) transmission cycle?

A

Tyrosine into terminal ->
∆ to DOPA then dopamine ->
∆ to NE ->
released to receptors

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10
Q

DOPA synth blocked by?

A

metyrosine

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11
Q

NE in vesicle depleted by?

A

reserpine

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12
Q

NE re-uptake blocked by?

A

cocaine and TCAs

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13
Q

NE release ↑ by?

A

amphetamines, tyramine

but only if terminal is intact

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14
Q

NE metabolized by?

A

MAO and COMT

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15
Q

Cholinergic receptors? (4)

A

M1: sweat glands, CNS
M2: heart, smooth mm, presynaptic
M3: exocrine, smooth mm, endothelium
Nicotinic: Na+ channel, Nn, Nm

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16
Q

Cholinergic receptors controlled what:

M1
M2
M3

A

M1 and M3: Gq/11; PLC, IP3, DAG

M2: Gi; inhibits adenylyl cyclase

17
Q

Adrenergic receptors? (5)

A
α1: smooth mm, excitatory
α2: presynap terminals, some smooth mm
β1: heart
β2: heart, bronchioles, skeletal mm blood vessles
β3: fat cells (lypolysis)
18
Q

Adrenergic receptors control what:

α1
α2
all β

A

α1: Gq; PLC, IP3, DAG

α2: Gi; inhibits adenylyl cyclase

all β: Gs; stim adenylyl cyclase

19
Q

Dopamine receptors?

A

D1, D5: brain, vascular bed

D2, D3, D4: brain, other tissues

20
Q

Dopamine receptors controlled what:

D1, D5
D2, D3, D4

A

D1, D5: ↑ cAMP

D2, D3, D4: ↓ cAMP

21
Q

Down-Regluation is?

A

constant stim w/ agonist causes:

↑ destruction of receptors or
∆ in affinity which ↓ receptor response

22
Q

Up-Regulation is?

A

lack of stim causes:

# of receptors to ↑ or
response of receptor to ↑
23
Q

Parasymp response in:

heart, bv, lungs

A

↓ HR and AV conduction (M2)

bronchoconstriction (M3)

24
Q

Symp response in:

heart, bv, lungs

A

↑ HR, AV conduction and contractility (β1)
bronchodilation (β2)
bv constriction (α1)

25
Parasymp response in: | glands, eyes
miosis, accommodation ↑ mucus, salivation, lacrimation (M3)
26
Symp response in: | glands, eyes
mydriasis, vasoconstriction, salivation (α) | sweating (M1)
27
Parasymp response in: | GI
↑ hydrochloric acid secretion, ↑ motility, relax sphincters (M3)
28
Symp response in: | GI
glycogenolysis (β2), | ↓ motility (α2, β2)
29
Parasymp response in: | GU
contract bladder, relax sphincters, promote erection (M3)
30
Symp response in: | GU
renin secretion (β1), relax bladder and uterus (β2), contract sphincters, ejaculation (α1)
31
Baroreceptor reflex initiated by?
NE release: α causes vasoconstriction β1 ↑ HR/contractility = ↑ arterial pressure
32
Baroreceptor response to ↑ arterial pressure in aortic arch?
↑ afferent impulse to medulla: ↓ symp -> vasodialtion ↑ parasymp -> ACh release -> ↓ HR and CO
33
Muscarinic receptors in ciliary mm do what?
constrict = lens rounds
34
Pupil size controlled how?
Symp stim of α1 receptor in iris radial mm = contract to dilate pupil Parasym stim of M3 receptor in iris circular mm = contract to constrict pupil
35
Summary of eye: Muscarinic Agonists do?
contract circular mm (constriction), contract ciliary mm (accommodation), ↑ outflow aqueous humor into canal of Schlemm, ↓ intraocular pressure
36
Summary of eye: Adrenergics do?
contract radial mm (dilation), ↑ prodxn aqueous humor, ↑ intraocular pressure