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PHARMAC > Anrifungals > Flashcards

Anrifungals Flashcards

1
Q

Griseofulvin

A

Inhibits microtubules by binding to TUBLIN protein

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2
Q

Flucytosine

A

Converted to 5-FU —> inhibits DNA replication and transcription

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3
Q

ECHINOCANDINS — Micafungin , caspofungin

A

Inhibit beta (1, 3) GLUCAN SYNTHASE ( essential for cell wall synthesis) . decrease cw resistance to osmotic forces

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4
Q

TERBINAFINE

A

Inhibit SQUALENE EPOXIDASE ( Dec erogosterol synthesis )
cell membrane stability decrease

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5
Q

AZOLES

A

Inhibit CYP450 14 -ALPHA DEMYTHLASE ( Dec ergosterol from lanosterol)

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6
Q

TRIAZOLES — very powerful

A

Voriconazole
ITRA
ISAVU
POSA
FLU

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7
Q

IMIDAZOLES

A

Micaonazole
Clotrimazole
Ketoconazole

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8
Q

POLYENES. Amphoteric B
NYSTATIN

A

2 surfaces - 1 hydrophilic and 1 hydrophobic——> makes pore channels in cmemb.
Electrolyte imbalances — > cell lysis

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9
Q

Aspergillosis

A

VORICONAZOLE (Tx)
Isavuconazole
Echinocandins
Amohotericin

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10
Q

Cryptococcus pneumonia/ meningitis

A

1st 2 weeks —-> Amphotericin B + Flucytosine
After —–> Flucanozole

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11
Q

Blasto/Histoplasmosi/ coccidomycosis

A

ITRACONAZOLE
Fluconazole
Amphtericin B ,—refractory

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12
Q

Mucormycosis—– rhinocerebral sinusitis

A

ISAVUCINAZOLE +debridement
Amphotericin B

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13
Q

Tinea versicolor

A

Ketconazole/ micanozole. Topical

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14
Q

Onchomycosis

A

Terbinafine

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15
Q

Amphotericin

A

NEPHRITOXIC—-RFT
PHLEBITIS
BM SUPRESSIOM - ANEMIA
K+/Mg2+ decrease— torsade de pointe

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16
Q

Terbinafine

A

Hepatotoxic —-LFTs
Dysguesia – loss of taste

17
Q

Echinicandins

A

Hepatoxic
Flushing type of reaction

18
Q

Azoles

A

Hepatoxic
Inhibit of drug metabolism ( warfarin– Inc conc of drug — Inc bleeding risk)
Gynaecomastia and ADRENAL insufficiency( cortisol and aldosterone) –‐—-> ketaconazole
Torsade de points ( low K+ –> Inc QT interval)
Visual dysfunction—–Voriconazole

19
Q

Griseofulvin —-cyp450 inducer

A

TERATOGENIC
Hepatoxic
Dec drug efficacy

20
Q

Flucytosine

A

TERATOGENIC
BM suppress–*pancytopenia(

21
Q

Candidiasis oropharyngeal / intertrigous area

A

Nystatin (swish and swallow )
Clotrimazole lozenges

22
Q

Cand - esophageal

A

Flu/ itraconazole

23
Q

Cand - vulvovagina

A

Mica/Clotrimazole topical
Flucanozole po
Flucytosine

24
Q

Cand – systemic ( endocarditis , uti, ocular)

A

Echinocandins
Fluconazole po
Amphotericin B

25
Q

Cand – systemic ( endocarditis , uti, ocular)

A

Echinocandins
Fluconazole po
Amphotericin B

PHARMAC (3 decks)

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