Anorectal Disorders - GI Flashcards

1
Q

Anal fissures

A
  • Tears or ulcers in the skin of the distal anal canal
  • Tears – hard stool, loose stool: Constipation – opioid use
  • New Theory: Ulcers – ischemia from internal anal sphincter spasm, skin break down
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2
Q

Anal fissures - Dx

A

History
-Pain with defecation
-Hematochezia – not mixed in - on toilet paper
Physical
-GENTLE rectal exam - very painful
-90% on posterior midline, rest on anterior
-If on lateral edges, consider alternate reason: Crohn’s, CA, HIV
-Paper cut looking
-Slightly indurated edges signify chronic fissures

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3
Q

Anal fissures - test/tx

A

-Tests: More thorough digital rectal exams/imaging only warranted if initial treatment fails, or if there are other red flags
Treatment
-Treat constipation: High fiber, increased fluids, stool softeners
-Treat pain: Sitz baths, Topical analgesic (Nitroglycerin intra-anal (0.2-0.4%) apply bid x 6 weeks prn, Side effect: HA 2/2 vasodilation, consider topical CCB)
Treat chronic fissures
-OnabotulinumtoxinA – use by specialist
-Surgical sphincterectomy – side effects

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4
Q

Anorectal abscesses

A
  • Infection of the soft tissue around anus
  • 2/2 infected anal glands
  • Anal glands normally drain into the anal crypts
  • Crypts blocked by food matter, edema, inflammation
  • Strong association with anal fistulas (37%)
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5
Q

Anorectal abscesses - Diagnosis

A
  • History of fistulas, Crohn’s
  • Anal/perianal pain - worsening - very bad pain
  • Swelling/redness/growth/mass
  • Fever: if gone on for a long time, mild tachycardia - severe
  • If abscess occurs above the anal ring – may mimic pelvic/intra-abdominal pain
  • Extreme tenderness with digital rectal exam, may need anesthesia
  • Induration (hardened area) within 3 cm of anus

Tests

  • WBC – leukocytosis
  • If recurrent, or patient is immune compromised, consider cx (culture)
  • CT or MRI if unsure of diagnosis
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6
Q

Anorectal abscesses - Tx

A
  • Incision and drainage: In OR or procedure room is best, Dependant on position, can drain to outside, or into anal canal
  • If recurrent, refer to GI: Crohn’s, fistula

Antibiotics

  • Diabetic, Elderly, Immunocompromised, Concomitant cellulitis
  • Ampicillin/Sulbactam (Unasyn) 1 g PO/IV qid and -Metronidazole (Flagyl) 500 mg PO/IV qid

Follow-up/Complications

  • Incomplete drainage
  • Necrotizing infection
  • Sepsis
  • Recurrent abscess – look for other causes
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7
Q

Anal fistulas

A
  • Results of chronic anal abscess
  • Epithelialized track forms to connect abscess to perirectal skin
  • Less common causes: Crohn’s disease, Lymphogranuloma venereum (chlamydia), radiation proctitis, rectal foreign bodies, actinomycosis
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8
Q

Anal fistulas - Dx

A
  • History of non-healing abscess
  • Drainage from rectum – purulent, malodorous
  • Pain with defecation, sitting
  • Pustule like lesion
  • Perianal skin – excoriated, inflamed
  • Possibly see external opening – inflamed, tender, fluid
  • Fistula probe – experienced clinician

Tests

  • Imaging: Ultrasound, CT, MRI
  • Anoscope, sigmoidoscope
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9
Q

Anal fistulas - tx

A

Surgical

  • If I&D of abscess ineffective 6-12 wks later, surgery indicated
  • Dependent on type of fistula - classification
  • Goals: Retain continence, Remove fistula, Close track or keep it open, Prevent recurrence
  • Fistulotomy, fibrin sealant, setons
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10
Q

hemorrhoids

A
  • Hemorrhoidal cushions are vascular beds within the anal canal
  • When the cushions dilate and engorge, they can cause symptoms and are classified as hemorrhoidal disease
  • Classified by the location in relation to the dentate line
  • External – below the dentate line
  • Internal – above the dentate line
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11
Q

hemorrhoids - dx

A
  • BRBPR - bright red blood per rectum
  • Blood following bowel movement, on tissue or in toilet bowl
  • Feeling of incomplete evacuation
  • History of constipation, straining, or increased intra-abdominal pressure (wt. lifters, obesity, pregnancy): often lead to hemrrhoids
  • Internal hemorrhoid – painless, no mass felt
  • External hemorrhoid - painful bowel movements, mass protruding from anus

Tests

  • Hemoccult – if no blood seen
  • CBC – if suspicious of anemia
  • Endoscope – r/o more serious condition if other red flags
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12
Q

hemorrhoids - tx

A
  • Treat symptoms
  • Mild bleeding: Increase fluids and fiber, Topical steroids to treat pruritis and pain (Hydrocortisone rectal 2.5%, apply bid x 5-7d MAX)

Internal Hemorrhoids
-Rubber band ligation, infared photocoagulation, sclerotherapy, arterial ligation, stapled hemorrhoidopexy

External Hemorrhoids

  • Surgical excision
  • “De-roofing” thrombosed hemorrhoids can be done in office
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13
Q

Rectal prolapse (procidentia)

A

Complete prolapse
-Protrusion of all the layers of the rectum through the anus

Partial prolapse
-Protrusion of mucosal layer only

Risk Factors
-Female, > 40 y.o., multiparous, vaginal delivery, prior pelvic surgery, chronic straining, diarrhea or constipation; CF, dementia, stroke, pelvic floor defects (-cele), pelvic floor dysfunction

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14
Q

Rectal prolapse - dx

A

-Incomplete evacuation
-Rectal mass
-Abdominal discomfort – rectal pain is Uncommon
-History of risk factors
-Prolapse may by intermittent – squatting helps
-Decreased sphincter tone
-Check for concomitant pelvic floor disorder
Tests
-Unnecessary - clinical

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15
Q

Rectal prolapse - tx

A

Medical Management

  • Fluids – 1-2 L per day
  • Fiber – incr dietary intake, supplement to 25-30 g/day
  • Enemas and suppositories to treat constipation
  • Last resort – taping a pad against buttock

Surgical

  • Only attempt for cure
  • Intra-abdominal approach
  • Rectopexy – “unstraighten” the rectum, move rectum posteriorly and attach it to sacral promontory
  • Can be with or w/o sigmoid resection if redundant sigmoid tissue

Perineal Approach

  • If intra-abdominal not tolerated
  • Or young men – spares hypogastric nerves, no ED
  • Rectosigmoidectomy
  • Delorme procedure
  • Both involve removal of the redundant sigmoid and anastomosing remaining sigmoid to rectum

Recurrence

  • Up to 27% with intra-abdominal and 38% with -perineal approaches
  • Incontinence
  • Constipation
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16
Q

Anal cancer

A
  • Classifications based on type of mucosa lining the anus
  • Glandular – Adenocarcinomas, rare, treated as rectal adenocarcinomas
  • Transitional and Squamous – Squamous cell carcinomas
  • Above pectinate line: nonkeratinizing SCC
  • Below: keratinizing SCC
  • Perianal skin cancers – treated as skin cancers
  • Rare: 6,230 cases anually
  • Risk factors: HPV, Receptive anal intercourse, HIV, Smoking
17
Q

Anal cancer - Dx

A

History

  • Hx of risk factors
  • Anal condyloma
  • Mostly asymptomatic: 20%
  • Anal pain, bleeding, discharge, rectal mass

Physical

  • Skin discolorations
  • Mass: wart like on external skin, firm on DRE
  • Enlarged lymph nodes in groin (may be presenting sx)
  • If there is blood (frank or occult), and you don’t see a hemorrhoid, don’t assume it is one

Tests

  • Biopsy of mass
  • CT chest, abdomen, pelvis
  • Consider PET scan for other active sites
  • Pap smear and thorough pelvic for women
18
Q

Anal cancer - Tx

A
  • Anal cancer: Radiation and chemotherapy (5-FU and mitomycin)
  • Adenocarcinomas – APR, adjuncts of RT and chemo
  • Perianal skin cancers – local excision, +/- LN bx

Follow-up/Complications

  • For persistent or recurrent CA, consider surgery
  • APR – abdominoperineal resection: Removes rectum and anus, Requires use of colostomy bag
  • Follow-up: Re-examine every 3-6 months