ANISO & POIKILO

Question 1

range from egg shape slightly oval to sausage, rod, or pencil forms

associated conditions:
1. 25-90%
2. 10%
3. 1 Ovalocyte condition
4. 1 Elliptocyte condition

Answer 1

OVALOCYTES

1. Hereditary Elliptocytosis
2. Acquired Elliptocytosis
3. Megaloblastic Syndrome
4. Idiopathic myelofibrosis

Question 2

smaller than rbc, no visible central pallor, concentrated hb content

associated conditions:
1. Hereditary Spherocytosis aka
2. Ab to the red cell will attached to the red cell w/ their FC portion exposed which will be recognized by macrophages that have Fc receptors on their receptors & they pit off
3. Other Mechanisms (3)

Answer 2

SPHEROCYTE

1. Intrinsic C Membrane Defect
2. Autoimmune Hemolytic Anemia
3. • Normal aging process
   • Storage phenomenon
   • Severe burns

Question 3

with irregularly sized & unevenly spaced 10-30 blunt spicules

associated conditions:
1. occur in situations that cause a change in tonicity (_____) of the intravascular fluid plasma seen in ____ & _____ related to uremia
2. wherein kidneys important in removing metabolic waste in the blood, it also filters blood but do not remove abnormally shaped cells & inclusions.

Answer 3

BURR CELL

associated conditions:
1. HYPERTONIC; Dehydration & Azotemia
2. Renal Insufficiency

Question 4

with irregularly sized & unevenly spaced 10-30 blunt spicules

associated conditions:
1. occur in situations that cause a change in tonicity (_____) of the intravascular fluid plasma seen in ____ & _____ related to uremia
2. wherein kidneys important in removing metabolic waste in the blood, it also filters blood but do not remove abnormally shaped cells & inclusions.

Answer 4

BURR CELL

associated conditions:
1. HYPERTONIC; Dehydration & Azotemia
2. Renal Insufficiency

Question 5

with few (3- 12) irregularly spaced, pointed spicules/thornlike projections of various lengths and widths

associated conditions:
1. when there is _____ due to liver disease this may lead to abnormal ratio of plasma lipids leading to distortion of RBC
2. alcohol intoxication affects liver leading to _____
3. without this as it is important in maintaining cell membrane
4. absence of betalipoprotein which is related to the inability of the liver to metabolize it
5. removal of spleen, all abnormalities will be seen in the circulation

Answer 5

ACANTHOCYTES

associated conditions:
1. hypercholesterolemia
2. ALCOHOLIC CIRRHOSIS
3. PK DEFICIENCY
4. CONGENITAL ABETALIPOPROTEINEMIA
5. POST-SPLENECTOM

Question 6

Normal sized cell with an elongated or a slit like mouth or stoma of central pallor; defect in transport of Na/K

associated conditions:
1. second major blood group (rhesus blood group), the Ag in this blood group are the capital D indication of positive or negative & also C & E

Answer 6

STOMATOCYTES (MOUTH CELLS)

associated conditions:
1. RH NULL DISEASE

Question 7

With a central area or
hb surrounded by a
colorless ring and a
peripheral ring of hb

associated conditions:
1. give two

Answer 7

Target Cells
(Codocytes)

associated conditions:
1.
- Hemoglobinopathies
- Thalassemia

Question 8

Fragments of RBCs
varying in shapes

associated conditions:
1. hallmark of

Answer 8

SCHISTOCYTES

associated conditions:
1. Hemolytic anemias

Question 9

erythrocytes with pair of spicules or horns surrounding a gap in cell outline

associated conditions:
1. give 2

Answer 9

Keratocytes, Bite
Cells, Degmacytes

associated conditions:
1.
- Hemolytic Anemia
- G6PD deficiency

Question 10

half moon/crescent cells; large pale pink staining ghost of RBC

associated conditions:
1. give one

Answer 10

SEMILUNAR BODIES

associated conditions:
1. overt hemolysis

Question 11

pear shaped or tear with single elongated point

associated conditions:
1. bone marrow is infiltrated by fibrous materials
2. bone marrow is infiltrated w/ abnormal cell like in leukemia thus circulation becomes limited

Answer 11

Teardrop Cells
(Dacrocytes)

associated conditions:
1. Myelofibrosis
2. Myelophthisic Anemia

Question 12

smaller than Spherocytes; lack central pallor also

associated conditions:
1. due to this thermal injury on RBC membrane wherein fats are easily damage causing the membrane to vesicle
2. For Pyropoikilocyte: there is a membrane damage of red cell due to sensitivity to heat.

Answer 12

MICROSPHEROCYTES & PYROPOIKILOCYTE

associated conditions:
1. SEVERE BURN
2. HEREDITARY PYROPOIKILOCYTOSIS

Question 13

Thin and elongated with
pointed ends.

associated conditions:
1. give 1
2. w/ one or more
fingerlike, blunt-pointed projections that protrude from the cell membrane leaving a pale area at the opposite end
2. hexagonal; Formed within the membrane (RBC)

Answer 13

Drepanocytes/Sickle cells

associated conditions:
1. Sickle cell anemia
2. Hb SC Crystal
3. Hb CC Crystal

Question 14

Other appearances related with hemolysis:
1. with thinned portion
2. appear like “pinched
bottle”
3. distorted red cells

Answer 14

1. Blister cell
2. Knizocytes
3. Pyknocytes

Question 15

Morphological Appearance:
1. Normocyte size
2. Normocyte MCV
3. Presence of 2 distinct populations of red cells that may differ in size, shape or hemoglobin content

Answer 15

1. 7-8um
2. 80-100fL
3. Dimorphic RBC

Question 16

ANISOCYTOSIS & POIKILOCYTOSIS GRADING

Normal
Slight
1+
2+
3+
4+

Answer 16

5%
5-10%
10-25%
25-50%
50-75%
>75%