Animal Nutrition Test 3 Flashcards

1
Q

Carbs are:

A

Polyhydroxyaldehydes or polyhydroxyketones, or substances that yield them on hydrolysis

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2
Q

Gum is a:

A

Carb

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3
Q

What percentage of an animals body is carbs?

A

Less than 1%

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4
Q

Carbs form what percent of the dry weight of forages? Seeds?

A

70%, up to 85%

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5
Q

Feeds classified as carbs generally occupy what percent of the diet on a weight basis?

A

Over 80%

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6
Q

Major function of carbs:

A

Dietary energy

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7
Q

Energy reactant in photosynthesis

A

686 Kcal

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8
Q

Chemical composition by % molecular weight of carbs is:

A

C: 40%
H: 7%
O: 53%

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9
Q

How much more energy/calories does fat contain than carbs on an equal weight basis?

A

2.25x

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10
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Arabinose

A

Pentose monosaccharide

Polysaccharides found in: araban and pectin

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11
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Xylose

A

Pentose monosaccharide

Found in polysaccharides, corn cobs, and wood

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12
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Ribose

A

Pentose monosaccharide

Found in nucleic acids NOT IN POLYSACCHARIDES

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13
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Glucose

A

Hexose monosaccharide

Found in disaccharides (literally all of them that I list), polysaccharides, honey, fruits, and plant sap

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14
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Fructose

A

Hexose monosaccharide

Found in disaccharides and inulin

The sweetest monosaccharide, the only ketone hexose

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15
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Galactose

A

Hexose monosaccharide

Found in milk (lactose disaccharide)

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16
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Mannose

A

Hexose monosaccharide

Found in polysaccharides

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17
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Sucrose (table sugar)

A

Disaccharide, glucose + fructose

Found in sugar cane and beets

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18
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Maltose

A

Disaccharide, glucose + glucose (4-a linkage)

Found in starchy plants and roots

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19
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Lactose

A

Disaccharide, glucose + galactose

Found in milk

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20
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Cellobiose

A

Disaccharide, glucose + glucose (4-B linkage)

Found in the fibrous portion of plants

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21
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Raffinose

A

Trisaccharide/oligosaccharide, glucose+fructose+galactose (sucrose+galactose)

Found in certain varieties of eucalyptus, cottonseed, and sugar beets (sucrose is found in sugar beets too!)

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22
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Araban

A

Polysaccharide pentosan made of arabinose

Found in pectins (just like arabinose)

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23
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Xylan

A

Polysaccharide pentosan made of xylose

Found in corn cobs and wood (just like xylose)

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24
Q

Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide.

Starch

A

Polysaccharide hexosan made of glucose (maltose)

Found in grains, seeds, tubers, rhizomes, and fruits

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25
Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide. Dextrin
Polysaccharide hexosan, breakdown unit of starch so 3-8 units of glucose
26
Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide. Cellulose
Polysaccharide hexosan made of 3,000-5,000 units of glucose (cellobiose) Found in the cell wall of plants (the fiber found in the stem, leaves, and roots)
27
Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide. Glycogen
Polysaccharide hexosan made of glucose so it's very similar to starch Found in the liver and muscle of animals
28
Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide. Inulin
Polysaccharide hexosan made of fructose Found in potatoes, tubers, and artichokes
29
Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide. Hemicellulose
Mixed polysaccharide that is a mixture of pentoses (mostly) and some hexoses Found in fibrous plants
30
Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide. Pectins
Mixed polysaccharide that is a mixture of pentoses, hexoses, and salts of complex acids Found in citrus fruits and apples
31
Classify the following carb as either a monosaccharides (pentose or hexose), disaccharide, trisaccharide, polysaccharide (pentosan or hexosan), or mixed polysaccharide. Gums (partially oxidized to acids)
Mixed polysaccharide made up of pentoses and hexoses Found in acacia trees and some plants
32
Oligosaccharide has how many sugars?
3-10
33
Glycose=
A monosaccharide
34
What are the only monosaccharides that occur in free form in nature?
Glucose and fructose Both are WATER SOLUBLE and sweet
35
Are pentoses dietary essentials?
No, they can be made from hexoses, protein, and glycerol
36
What is ribose found in?
ATP, ADP, riboflavin, and RNA
37
Digestibility of hemicellulose
Partially digestible because of acidic conditions in the stomach Insoluble in boiling water, soluble in dilute alkali, readily degraded by dilute acid Mammals don't make enzymes to digest it Closely associated with lignin in the cell wall
38
Most abundant carbs found in nature
Hexoses
39
2 functions of hexosans
1) Make up a major part of the animal and human diet (starch and cellulose) 2) they serve as both fuel and intermediates in metabolic pathways
40
2 functions of glucose in metabolism:
Glucose is the major carb used for energy at the cellular level. All digested dietary carbs are converted to glucose, making it a dietary essential Major circulating carb in the blood
41
Haworth perspective
The position of the H and OH groups on C1 determines if the compound is in alpha or beta form
42
Where are derivatives of galactose found?
Brain and nervous tissue
43
What 1 species can't use galactose?
Poultry, they don't have lactase
44
Form of inulin found in plants?
Mannans
45
Order these from sweetest to nonsweetest: ``` Sucrose Glucose Fructose Lactose Maltose Saccharine Aspartame ```
Saccharine, aspartame, fructose, sucrose, glucose, maltose, lactose
46
Other sources of sucrose besides sugar cane and sugar beets?
Ripe fruits, tree sap (maple sugar), vegetable, and sorghum (molasses)
47
What animal doesn't have sucrase activity?
Baby pigs until 7 days old
48
How does maltose get its name?
It's made commercially from starch via the malting process
49
What things can split cellobiose?
Microbial enzymes, fungal enzymes, or acid
50
What proportion of the solids in milk is lactose?
1/2
51
Methods of alleviating lactose intolerance?
1) put B-galactosidase in milk before drinking it (break the bond and it'll taste sweeter) 2) drink lactobacillus acidophilus milk (makes a different bacterial population in large intestine)
52
In cultured products such as yogurt, what percentage of lactose is fermented to lactic acid?
60%, better for lactose intolerant people
53
In what form do animals obtain most of their dietary carbohydrate?
Polysaccharide
54
Why do fruits get sweeter when ripening?
Conversion of starch to sugars
55
Amylose makes up what percentage of starch in most plants?
25-30%
56
Amylopectin makes up what percentage of starch in most plants?
70-75%
57
Characteristics of amylose
Soluble in hot water Straight chains of glucose a-1,4-linkage only Helix
58
Characteristics of amylopectin
``` Insoluble in water Branched chains of glucose (more sites for enzymes to attach so more digestible than amylose) a-1,4-linkage AND a-1,6 cross linkages Phosphorous found One of the largest MW in nature ```
59
Frequency of phosphorus found in amylopectin?
1 in every 400 glycose units
60
Molecular weight of amylopectin?
A million or more
61
When you hydrolyze or apply high heat to starch, what do you get?
Dextrin (3-8 glucose units)
62
Glycogen is what percent of weight weight of liver?
Usually 2-8% in most species, can be up to 10%
63
Is glycogen water soluble?
Yes (pure polymer of glucose, which is water soluble)
64
What level will liver glycogen be at after 24 hours of fasting?
0
65
Most abundant substance in the plant kingdom?
Cellulose Also the single most abundant organic compound in the world
66
Cellulose occupies what percentage of the dry matter of all vegetation?
About 50%
67
Is cellulose soluble in water?
No
68
Name the 3 heteropolysaccharides
Pectin, hemicellulose, and gums
69
Composition of hemicellulose
60-80% xylose and arabinose (pentoses), galactose, glucose, and others
70
Hemicellulose covalently links to ____ and then hydrogen bonds to _____
Pectin, cellulose Remember lignin is close by too
71
Digestibility of pectin
Depends on microbes so questionable value to monogastrics Much of it is digested, even by humans, however. So it must be a readily fermentable fraction for the microbes for to be true
72
Function of pectin
Holds water! Used as diarrhea medicine, given to cows in the form of beet pulp to make ruminoreticulum expand and cow has spring of rib Also used in dairy rations as fiber to balance fiber fraction
73
Pectin is similar to:
Hemicellulose
74
What is starch's job?
Energy reserve in roots, tubers, and seeds This is why glycogen is called "animal starch" because it's an energy reserve in animals
75
How much lipid is in most diets?
Usually less than 5%, carb is much more plentiful energy form in food
76
Ultimate source of energy for most animal cells?
Glucose
77
What classification of carbs can be absorbed form the gut?
Monosaccharides
78
Digestion of amylose and amylopectin
Digested by the same enzymes because hydrolysis of both to glucose is similar
79
Lignin is a mix of:
Polymers and phenolic acid
80
Characteristics of lignin
Increases with plant age Found with hemicellulose and cellulose in cell walls Effects bioavailability of cellulose and hemicellulose for microbial use
81
Sources of lignin
Legumes are high in lignin Grasses are intermediate in lignin Veggies and cereal are low in lignin
82
Can pigs use VFAs?
Yes, microbes in large intestine can make VFAs from fiber These VFAs can provide some of the energy required for maintenance May be as much as 30% of the digestible energy intake due to a cellulolytic enzyme in the pig large intestine
83
3 major groups of microbes found in the rumen?
Small bacteria (largest in microbial mass), ciliated protozoa, and fungi
84
Areas of monosaccharide absorption
Duodenum and Jejunum > ileum> stomach and large intestine
85
Disaccharidase deficiency
Serious GI upsets No sucrase in young mammals and ruminants = severe diarrhea or death when fed large amounts of sucrose No lactase in adult pigs and some humans= diarrhea when fed lactose Fewer starch-splitting enzymes in ruminants than nonruminants
86
Absorption rate of soluble carbs? Does it vary greatly from animal to animal?
90%, no
87
Factors affecting the rate of digestion of starch
Particle size, nature of the starch (amylose vs amylopectin), interactions of starch with proteins and fat, and the presence of antinutrients (tannins, phytate, saponins, and enzyme inhibitors)
88
What happens to monosaccharides other than glucose after absorption?
If they weren't turned into glucose by the mucosa cell during absorption, then they'll be turned to glucose in the liver. The glucose can either be turned to fat or glycogen if it's being stored, but fat is much more likely than glycogen
89
Purpose of glycogen
It can be hydrolyzed RAPIDLY back to glucose (fat is slower!) or vice verse to keep circulating blood glucose within a narrow range
90
Glycogenesis
Glucose --> glycogen
91
Glycogenolysis
Glycogen --> glucose
92
What hormones control blood sugar regulation?
Insulin and glucagon from the pancreas
93
Oxidative phosphorylation
Using the energy of oxidation (giving electrons from a substrate to oxygen) to phosphorylate ADP to ATP Driving force for absorption of nutrients from the GI tract and synthesis of the 4 macromolecules
94
Gluconeogenesis
When the body tissues (liver and sometimes kidneys) make glucose from noncarbs like lipids and amino acids.
95
Glucogenic
When metabolized it gives rise to a net increase in glucose
96
Amino acids that are glucogenic only:
All the nonessential amino acids (everything that's not MATT HILL VP! Remember arg, three Tylers? Let's drown him in phenol) Some of the essential amino acids: Met, His, Cys, Val, Thr, Trp, Arg (I met his sister Valerie three times, she tripped down the stairs and yelled arg)
97
Amino acids that are both glucogenic and ketogenic
Tyr, Ile, Phe, Lys (Tyler said, "I'll make you feel like you have lice")
98
Amino acid that is ketogenic only
Leucine
99
What happens when ingestion of carbs exceeds current needs?
Glucose --> pyruvate --> fat
100
The amino acids used for gluconeogenesis or for energy enter the TCA as:
Acetate, pyruvate, or a-ketoglutarate
101
Two fates of pyruvate
Converted to acetyl CoA in the mitochondria Reduced to lactate in the cytoplasm by oxidation of NADH
102
How much total energy is released in the conversion of glucose to CO2 and water?
673 kcal (remember: 686 reactant for photosynthesis)
103
What is the efficiency of the conversion of the free energy of oxidation of glucose?
40-60%
104
What animals does ketosis affect?
Lactating cattle and pregnant sheep also swine during starvation, pregnant ewes, and dairy cows with B12 deficiency
105
Define ketosis
An excess of ketones (acetone, acetoacetate, and B-hydroxybutyrate) in TISSUES bc of a disorder in CARB OR LIPID (energy) metabolism Ketonemia/acetonemia = increased ketones in BLOOD Ketonuria = increased ketones in URINE Treat by restoring normal blood glucose because CHARACTERIZED BY LOW BLOOD GLUCOSE
106
Rumen microbes have enzymes that can hydrolyze cellulose present in cell walls in:
Leaf, stem, and outer bran layer of seeds
107
What can termites do
Break down lignin (chief constituent of trees)
108
Extensins
PROTEINS that are in the structural components of plants. Proteolytic enzymes can't degrade them so they have low bioavailability
109
Van Soest
Neutral detergent gives NDF (cellulose, hemicellulose, and lignin) Acid detergent gives ADF of lignin and cellulose and ADS of hemicellulose H2SO4 digestion gives insoluble lignin and soluble cellulose Hemicellulose > cellulose > lignin based on solubility
110
How might recombinant DNA technology assist in improving fiber digestion?
Cloning cellulases to change microbial activity so that it can break the cellulose-hololignin bond Produce superior cellulolytic microbes
111
Is lignin a carb?
No
112
Amorphous
No particular structure Lignins structure depends on the plant species
113
Lignin
Resistant to degradation by acids or alkali Reduces digestibility of PROTEIN too!
114
When does the amount of lignin in a plant escalate?
Around the time of setting of seed. Thus, many forages are harvested when they're beginning to bloom or right before
115
What things can break the bond between lignin and other things AND degrade the lignin itself?
AEROBIC microbes and fungi Strong alkali can only break the bond- it leaves the lignin intact Note: rumen organisms can't do either!
116
Carb fractions found in the stem, leaf, and seed?
Fiber, monosaccharide, and starch
117
Fiber, monosaccharide, and starch in the stem
Fiber: lots of it Monosaccharide: a little being transported from leaves to seeds Starch: none
118
Fiber, monosaccharide, and starch in leaves
Fiber: some Monosaccharide: lots from photosynthesis Starch: none
119
Fiber, monosaccharide, and starch in seeds
Fiber: some (but not much) because of hull/seedcoat Monosaccharide: some (but not much) as precursor of starch Starch: lots to nourish the seedling
120
What percentage of grains is starch?
60-80%
121
How digestible is starch?
80-90% digestible
122
What percentage of grains is cell wall?
Less than 15%
123
Cell wall and lignin content of green pasture vs dormant pasture
Green pasture has less cell wall content and less lignin Dormant pasture has more of both
124
Cell wall and lignin content of hay vs silage
Exactly the same for both
125
What percentage of a hull/seedcoat is cell wall?
60-80%
126
How digestible are hulls/seedcoats?
Highly digestible, 60-80% because they only have 2-3% lignin
127
3 things are lipids have in common
1) insoluble in water but soluble in organic solvents 2) they are actually or potentially fatty acid esters 3) utilized by living organisms
128
Elemental composition of lipids by % MW:
C: 77% H: 12% O: 11%
129
Classifications of the lipids of nutritional importance:
Simple lipids, compound lipids, derived lipids, sterols, and terpenes
130
Simple lipids
Fatty acids+alcohols Fats and oils (these make up largest fraction of lipids in most material), and waxes (waxes are the only ones with an alcohol different than glycerol. They're unimportant and not used well by body)
131
Energy value of fats vs carbs
9.45 kcal/gram for fat, 4.1 kcal/gram for carbs
132
Compound lipids
Fatty acid + lipid + SOMETHING ELSE Phospholipids, glycolipids (sometimes contain N), and lipoproteins. The last two are used for metabolism and are scarce
133
Derived lipids
Substances derived from simple or compound lipids by hydrolysis Fatty acids, glycerol, and other alcohols
134
Sterols
Lipids with complex phenanthrene-type structure (used for metabolism, scarce)
135
Terpenes
Have isoprene-type structure Unimportant, not used well by the body
136
Most important lipids in nutrition
Fatty acids, glycerol, mono-, di-, and triglycerides, and phospholipids
137
All neutral fats contain:
Glycerol
138
Chain length of fatty acids
Can be from 2-24 carbons long (even number), but the most common fatty acids have 16-18 carbons
139
Naturally occurring variations in fatty acids:
Odd number of carbons, branched chains, or hydroxy acids These are less plentiful but found in ruminants due to microbial synthesis
140
Almost all naturally occurring lipids contain one or more:
Fatty acid
141
Which are more reactive: saturated or unsaturated fatty acids?
Unsaturated bc of the double bond
142
Omega-3 and omega-6 fatty acids
Long chain unsaturated fatty acids in depot fats (adipose) of fish They consist of: linoleic acid, eicosapentaenic acid, and docosahexaenoic acid (DHA) Where double bond is is critical to biological activity
143
Carbons and double bonds in linoleic acid?
18 C, 3 double bonds
144
Carbons and double bonds in eicosapentaenic acid?
20 carbons, 5 double bonds
145
Carbons and double bonds in DHA?
22 carbons, 6 double bonds
146
What do fish oils protect against?
Atherosclerosis (CHECK THIS ONE)
147
Benefits of CLA isomers to humans?
Protect against cancer, diabetes, atherogenesis, and obesity Modulates immune function and bone growth
148
Primary form of lipid in nature
Mono di and triglycerides
149
2 factors that determine physical and chemical properties of fatty acids:
Chain length and degree of unsaturation
150
Liquid fat at room temperature
Unsaturated or saturated with a chain length less than 10 More than 10 saturated is solid
151
3 tests used to characterize the chemical properties of fats:
Saponification number: chain length Reichert-Meissl (RM) number: proportion of VFAs present Iodine number: degree of hydrogenation/saturation
152
Common characteristic of a phospholipid
Ester phosphorus
153
Function of phospholipids
Cell organization, also involved in mitochondrial enzyme systems and lipid transport because of their emulsifying properties
154
Lecithin
White, waxy phospholipid that oxidizes to brown in the presence of oxygen Basically phosphatidyl CHOLINE Keeps oils and water together (mayonnaise and milk)
155
Steroids and sterols are derivatives of:
Cyclopentanoperhydrophenanthrene (phenanthrene ring)
156
Erogsterol + sunlight =
Vitamin D
157
In what locations are steroid hormones made from cholesterol?
Adrenal cortex, gonads, corpora lutea, and placenta
158
What are adrenal steroids involved in?
Carb and protein metabolism, fluid and electrolyte balance, blood pressure regulation, stress resistance, and more
159
What are estrogens and progesterones involved in?
Regulate estrus, reproductive cycles, influence protein and nucleic acid and lipid metabolism, and regulate normal bone metabolism
160
What are androgens involved in?
Make sex hormones responsible for secondary sex characteristics, sperm maturity, activity of accessory glands of the genital tract, and promotion of N retention
161
Ralgro
Pseudosterol used as a growth implant in beef cattle
162
4 major functions of lipids
Energy supply, EFAs, carry fat soluble vitamins, and components of membranes
163
Arachidonic acid is the precursor of:
Prostaglandins These are are a type of eicosanoid. Prostaglandins have many metabolic purposes such as lowering blood pressure, stimulating muscle contraction, inhibiting norepinephrine-induced release of fatty acids from adipose, and modulating immune function.
164
Which species requires dietary arachidonic acid?
Cat
165
Function of EFA
Not completely understood, but they are major parts of phospholipid and cholesterol esters that play a part in cell membranes and lipid transport moieties
166
EFA deficiency symptoms in monogastrics
``` Dull hair coat with possible loss Scaly skin Necrosis of tail Failure to grow Affected reproduction and lactation Eventual death ```
167
3 Sources of fats in livestock diet
Plants, pure sources of fat, and protected fat
168
Where do we primarily find fats in plants?
Seeds Oilseeds such as soybeans, cottonseeds, and mung beans contain from 18-25% lipid
169
Grain is the other source of fat in plants (besides seeds). What is the lipid content of corn, milo, wheat, etc?
2-4%
170
Pure sources of fat for humans
Soybean oil, cottonseed oil, corn oil, etc
171
Pure sources of fat in livestock rations
Tallow from beef and lard from hogs
172
The lipids found in feedstuffs are what percent digestible?
Normally greater than 80% digestible. Exceptions include wax and cutin
173
How much fat digestion occurs in the stomach?
Not much because gastric lipase has a higher optimal pH than the acidic conditions of the stomach More important in the young where the stomach pH is higher and the fats in milk are already emulsified (lecithin)
174
What 2 things increase the activity of pancreatic lipase?
Calcium and the bile salts (emulsify fats into water bc lipase is water soluble)
175
Most dietary fat is in what form?
Triglycerides. These are water-insoluble so they are emulsified in the stomach and further in the small intestine. This is a COARSE emulsion accomplished by peristaltic contractions
176
Where does pancreatic lipase work on the emulsion particle? How does bile help the lipase?
At the oil-water interface. Bile helps form the emulsion droplets and also helps to orient the lipase with the triglycerides for hydrolysis
177
Which positions does lipase free the fatty acids from the TG?
1 and 3
178
Which position does lipase free the fatty acid from the phospholipid?
From the 1 position. Only a lysolecithin is left
179
The bile acids are more effective in the presence of
Monoglycerides and lysolecithin. Therefore the digestion products promote further digestion
180
Overview of absorption of fat
Bile acids and monoglycerides form micelles. These take up fatty acids (>12) and degrade them. The micelle then goes to the brush border of the jejunum (which is aided by the peristaltic contractions of the gut) and is absorbed into the mucosa cell. Here, monoglycerides and made back into TGs. Next, a chylomicron is made and transported out of the cell via osmotic pressure into the central lacteal of the lymphatic system, to the thoracic duct at the right atrium, and to the body.
181
In the conversion of fats from an emulsion droplet to a micelle, the diameters of the particles is reduced ____ times and the surface area is increased over ____ times
100, 10,000
182
Some bile salts are also absorbed in the jejunum. Most are absorbed in the ileum. This system is ____ efficient.
95% efficient
183
Chylomicron composition:
``` Triglyceride: 80% Cholesterol esters: 9% Phospholipid: 7% Cholesterol: 2% Protein: 2% ```
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How to make fats from carbs
Glucose to pyruvate to acetyl CoA, which can either go to the TCA for energy production or undergo lipogenesis to make SATURATED fatty acids. These then become unsaturated and are used to make TGs, phospholipids, etc. To get a fatty acid (either saturated or unsaturated) back to acetyl CoA again, do beta oxidation (take 2 carbs off at a time at the carboxyl end until it's degraded)
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Whole plants are at a maximum up what percent lipids?
5%
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2 lipids consumed predominantly from ruminants:
TG from the seeds and galactolipids from the leaves
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In the rumen, glycerol is fermented to yield ____
Propionic acid
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What percent of the fats in beef are saturated?
50%
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Which fatty acids are absorbed by rumen microbes?
Short chain only! Remember all fatty acids are made saturated in the rumen Short chain can also be absorbed in rumen or passed down the tract.
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Fate of long chain fatty acids in the rumen
They form water-soluble salts (soaps) and pass on for absorption in the small intestine -not absorbed in rumen or used by microbes! Just pass on in the form of soaps
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What controls adipose tissue?
Nervous and endocrine system, so there's nerves and blood in adipose
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As the percent of fat in the body increases, the percent of water in the body:
Decreases
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Lipid concentration in milk
1.5%-50% in seals Nearly all milk lipid is TG (mammary glands actively make TG and secrete it into milk)
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Sources of fatty acids in milk:
Circulating TG Circulating nonesterified fatty acids originating in adipose tissue De novo fatty acid synthesis in mammary gland
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Principal fatty acid precursor in monogastrics
Glucose (turns into acetyl CoA to undergo lipogenesis to make saturated FAs to make unsaturated)
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Principal fatty acid precursors in ruminant mammary gland
Acetate and much smaller amounts of a-hydroxybutyrate (remember acetate is the precursor of milk fat! So we have to keep forage levels high)
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Where are fatty acids made
The microsome
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Overview of fatty acid synthesis
Made from acetyl CoA (from carbs, amino acids, or fats) The carboxyl end of one acetate (from acetyl-CoA) joins the methyl end of another. This repeats to eventually make palmitate, and then other fatty acids are made by modifications of palmitate
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Procedures to generate other fatty acids from palmitate?
Elongation, desaturation, and hydroxylation
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TG degradation
Either oxidized in place or transported to other tissues as albumin-fatty acid complexes for oxidation there Liver, heart, and resting skeletal muscles all rely on fatty acid oxidation for energy (ATP)
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Where does the glycerol from TG degredation go?
Liver, where it can either be used for energy or converted to glucose
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Fates of acetyl CoA
``` Entry into TCA Synthesis of long chain fatty acids Acetylation reactions Steroid synthesis Ketone body formation ```
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Exercise increases ____ levels
HDL, which is poorly associated with heart disease (LDL is)
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Eating beef promotes more ____ than _____
HDL than LDL
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What percent of the population will benefit from diet alterations?
2%
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Supplementation with _____ Will prevent arteriosclerosis?
Vitamin E, it's an antioxidant so it prevents the oxidation of lipids while they're circulating in the blood, which prevents arteries from being damaged and therefore makes them less susceptible to plaque lay down
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Ketogenesis
Continuous process, normally the ketones are removed rapidly from the blood by muscle They are used to supply energy
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Normally fat constitutes about __ of the wet weight of the liver, but it can be up to ____ or more in pathological conditions
5%, 30%
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Causes of fatty livers
High fat or high cholesterol diet Increased liver lipogenesis caused by excessive carb or excess intake of certain B vitamins Increased mobilization of lipids from adipose tissue caused by diabetes Starvation Hypoglycemia Increased hormone output (growth hormone, adrenal corticotrophic hormone, adrenal corticosteroids) Decreased transport of lipids from the liver to other tissues caused by deficiencies in choline, pantothenic acid, inositol, protein, or certain amino acids (met and thr)
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Atherosclerosis
NOT ARTERIOSCLEROSIS Characterized by progressive degenerative changes in the blood vessels and heart of humans and animals Associated with high serum cholesterol concentration (saturated fats raise it and eating cholesterol) LDL increases risk, HDL reduces it
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Average American (M+P)/S is _____
0.5:1 As this ratio goes up, less plasma cholesterol
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Omega-3's do what to the clotting time of blood?
Increase it, so it protects against the atherogenic process