Animal Models of Disease Flashcards
Define an animal model
Model used in research to obtain results that can be extrapolated to human medicine.
Name the top 3 most used animals for animal models
Mice
Fish (zebra fish)
Rats
Desribe and outline the 3 main purposes of experimental procedures.
-
Basic Research (55%)
- Proof of concept, pathways
-
Translational Research (17%)
- Apply results from basic research to produce new therapies/interventions
-
Regulatory Use (27%)
- Procudres carried out to satisfy legal requirements
- Studies safety, efficacy
What makes a good animal model (4)
- Comparable anatomy
- Comparable physiology
- Comparable pathogen response
- Can be extrapolated to human medicine
Explain a limitation to consider when using animal models
Not one animal model will be able to model one whole disease
It can only aim to study certain aspects of its phenotype
Outline some respiratory animal models used.
- Allergen/Asthma
- HDM
- OVA
- Oxidative stress
- Ozone exposure
Describe how a mild and severe asthmatic model can be designed.
-
Mild
- __Use of HDM/alum
- Th2 response
-
Severe
- __Use of HDM/CFA (Complete Freund’s Adjuvant)
- Mixed Th1 and Th2 response
In a HDM/alum model, describe the results with regards to:
Inflammation
Cells
Markers
Steroid
Disease
In a HDM/CFA model, describe the results with regards to:
Inflammation
Cells
Markers
Steroid
Disease
In an OVA model, describe the results with regards to:
Inflammation
Cells
Markers
Steroid
Disease
In an acute ozone model, describe the results with regards to:
Inflammation
Cells
Markers
Steroid
Disease
In a chronic ozone model, describe the results with regards to:
Inflammation
Cells
Markers
Steroid
Disease
