Angiotensin Receptor Blockers (ARBs)

Question 1

What is the action of angiotensin receptor blockers?

Answer 1

ARBs block (antagonists) of the angiotensin 2 type 1 receptor

(Type 1 receptor activation leads to inc aldoesterone, inc ADH, inc TPR)

*Remember aldoesterone is secreted from the adrenal medulla and functions to increase conservation of Na and secretion of K

Question 2

T/F All drugs that end in -sartan are ARBs (Angiotensin Receptor Blockers)

Answer 2

True

Question 3

What is the advantage of using ARBs over an ACE inhibitor?

Answer 3

No dry cough

Less severe adverse effects

Question 4

Direct renin blocker?

Answer 4

Aliskiren

a lis KYE ren

Question 5

What is the mechanism of action for aliskiren?

Answer 5

Direct renin blocker

Similar profile to ARB (No dry cough, less severe adverse effects)

Question 6

How do ARBs (Angiotensin II Type 1 Receptor Blockers) work?

Answer 6

Competitive antagonists of angiotensin II type 1 receptor

Question 7

Name the one ARB drug.

Answer 7

Losartan

Question 8

ARBs block the AT-R1 receptor. What does this cause?

Answer 8

Type 1 receptor activation leads to inc aldoesterone, inc ADH, inc TPR.

Block AT-R1 -> Dec Aldoesterone -> Release Na -> Dec blood volume -> Dec BP

Remember aldoesterone functions ton increase conservation of Na and secretion of K.