Angiotensin Receptor Blocker

Question 1

ARBs: Agents

Answer 1

Angiotensin Receptor Blocker

Lorsartan
Candesartan
Irbesartan

Question 2

ARBs: Indications

Answer 2

Chronic kidney disease
Diabetic nephropathy
Heart failure
Hypertension
Ischemic heart disease
Secondary prevention for CVD
Stroke

Question 3

ARBs: Mechanism of Action

Answer 3

ARBs block the action of Angiotension II
» by blocking receptor: angiotension type 1 receptor

> > lowers peripheral vascular resistance (afterload)&raquo_space; lowers BP
promotes sodium and water excretion
dilates glomeral arterioles

Question 4

ARBs: Side Effects

Answer 4

Hypotension
Hyperkalaemia
Renal failure
Renal artery stenosis&raquo_space; reversible if caught early

> > don’t cause dry cough or angiodema&raquo_space; ACE not inhibited

Question 5

ARBs: Contrainidications

Answer 5

Renal artery stenosis
Acute kidney injury
Pregnant or breast feeding
Chronic kidney disease&raquo_space; ARBs are used to treat CKD in low doses&raquo_space; should be monitored

Question 6

ARBs: Interactions

Answer 6

Potassium elevating drugs
ARBs + NSAIDS&raquo_space; nephrotoxicity
ARBs + duiretics&raquo_space; hypotension
ARBs + ACEi&raquo_space; hyperkalaemia

Question 7

ARBs: Monitoring

Answer 7

Clinical efficacy monitoring
Check renal function before and 1-2 weeks after

ARBs can be prescribed indefinitely&raquo_space; monitor regularly