Angiostrongyliasis

Question 1

In mice, cerebral irritation manifests as:

Answer 1

• Incoordination
• Disinclined to move
• Twitching, tight circling when stimulated
• Death

Question 2

Neuro-angiostrongyliasis in humans

Answer 2

• Larvae move from GIT to CNS
• Unable to mature, die in the brain damaging neuronal tissue
• Patients present with fever, headache, nausea, paralysis of the eye muscles

Question 3

Neuro-angiostongyliasis in guinea pigs

Answer 3

• Worms die surrounded by phagocytes

- No signs of cerebral irritation or any other abnormality

Question 4

Severe infections in humans

Answer 4

• Extensive paresthesias of trunk and lower extremities
• Bowel and bladder dysfunctions
• Weakness and hyporeflexia of legs

Question 5

Epidemiology

Answer 5

• Behaviour, population density and distribution important parameters in determining risk of exposure

Question 6

How is it transmitted to humans

Answer 6

• Freshwater prawns
• Crabs
• Planaria (worms)
• Frogs
• Raw snails

Question 7

Australian infections

Answer 7

Follow ingestion of salad vegetables with snails or slugs or infective larvae in slug or snail mucous