Angina Packet - Pharm

Question 1

what is most likely the main chemical mediator of anginal pain?

Answer 1

adenosine

Question 2

adenosine stimulates angina mainly by doing what?

Answer 2

stimulating a1 receptors in cardiac afferent nerve endings

Question 3

what type of angina is classified as occurring while or just after the heart has a need for extra oxygen?

Answer 3

stable or classical angina

Question 4

with stable angina what does the ST segment look like?

Answer 4

depressed

Question 5

what type of angina is characterized by coronary artery spasms as the main cause?

Answer 5

variant angina

Question 6

what is the ST segment like in variant angina?

Answer 6

elevated!

Question 7

what is the standard procedure for how to take nitrates?

Answer 7

take then lie down - take at night

Question 8

what is the most common sequelae for nitrates?

Answer 8

HA

Question 9

are arteries or veins more sensitive to vasodilation of nitrates?

Answer 9

veins

Question 10

what is the method of elimination of NG?

Answer 10

oxidized gluthathione

Question 11

do other methylaxanthine PDE inhibitors cause a potentiation of effect with NG like sildenafil does?

Answer 11

no. drugs such as theophylline do not cause similar interaction

Question 12

for which type of angina are beta blockers such as propranolol a good idea?

Answer 12

typical - and NEVER use for variant b/c NE at the alpha receptors cause v/c

Question 13

what order kinetics applies to the elimination of the drug (beta adrenergic agonists) from the plasma? what order applies to the decline in receptor block?

Answer 13

first order; zero order. the result is that after a few hours the blood concentration will fall more than the receptor block. so the effects seen from these drugs are really from the receptor block a lot of the times

Question 14

how are CCBs eliminated from the body?

Answer 14

via the liver; cyp450