Angina Flashcards
What leads to Typical Angina?
Increased Oxygen demand vs. limited supply
What are the 4 types of Angina?
- Typical (Stable)
- Variant (Prinzmetal’s)
- Unstable
- Microvascular (Syndrome X)
What leads to Variant Angina?
decreased supply of oxygen vs. unchanged demand
related to blood vessel spasm
What leads to Unstable Angina?
Decreased oxygen supply due to involvement of clotting, plaque or platelet issues. MOST DANGEROUS.
What leads to Microvascular Angina?
Atherosclerosis in a small coronary artery
Which drug classes are frontline agents for Angina?
Beta Blockers
Calcium Channel Blockers
Nitrates
What is the major determinant of myocardial oxygen supply?
Coronary blood flow
What are the primary determinants of myocardial oxygen consumption?
- Ventricular systolic blood pressure (afterload)
- Heart size (preload)
- Heart rate
- Myocardial contractility
Which drug classes used to treat Angina relax the resistance vessels?
- Nitrates
- Calcium Channel Blockers
- Beta Blockers
Which drug classes used to treat Angina relax the capacitance vessels?
Nitrates
Which drug class blocks or at least attenuates sympathetic influence on the heart?
Beta blockers
Which drug classes used to treat Angina dilate the coronary vessels?
Nitrates
Patients who use __________ need occasional ___________ periods to avoid the tolerance that comes from overstimulation and formation of disulfide bonds from endothelial sulfhydryl groups.
Nitrates
Abstinence
