Angina 01.15 Flashcards

1
Q

Acute Coronary Syndrome (ACS) initial treatment of MONA:

A

Morphine
Oxygen
Nitrates (GTN)
Aspirin

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2
Q

Secondary prevention of ACS - MI5 - what is this?

A
  1. Aspirin
  2. Clopidogrel
  3. Ace inhibitor
  4. Beta blocker
  5. Statin
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3
Q

SE of aspirin

A

GI irrit / bleed
Bronchospasm
Tinnitus

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4
Q

This drug - metabolised by CYP450 - inhibits platelet action & has similar SE to aspirin

A

Clopidogrel

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5
Q

Interactions of clopidogrel

A

Fluoxetine
PPIs
Enzyme inducers (carbamezapine)

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6
Q

SE of ace inhibitor eg ramipril

A

Cough
Hyperkalaemia
Renal & hepatic impairm

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7
Q

Interaction of ace inhibitors 2

A

Diuretics (-drop BP)

Nephrotoxic drugs

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8
Q

Beta blocker (atenolol) SE (4)

A

Bradycardia
Cold - raynauds
Bronchospasm
Sexual dysfunction

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9
Q

Interaction of beta blocker with these causes heart block

A

Calcium channel blockers - Verapamil & Ditiazem

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10
Q

Statins - SE (3)

A

Headache
Myalgia
Altered liver function

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11
Q

This drug inhibits HMG CoA Reductase, lowering LDL-C levels and enabling liver to remove LDL-C

A

Statins eg simvastatin

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12
Q

Interactions of statins

A

Enzyme inhibitors eg Grapefruit juice & clarithromycin

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13
Q

GTN releases what, which incr cGMP and causes vasodilation

A

Nitric Oxide

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14
Q

GTN s/e

A

Headache

Hypotension

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15
Q

GTN Contraindications 2

A

Hypotension

Aortic & mitral stenosis

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16
Q

Contraindication of beta blockers 2

A

Asthma & bradycardia

17
Q

This is a K channel activator - causing vasodilation by reducing Ca entry into cell and acting as an NO donor (3rd line treatment)

A

Nicorandil

18
Q

Contraindications of nicorandil (2)

A

Left ventricular failure

Hypotension

19
Q

SE of nicorandil (3)

A

Headache
GI irritibility
Hypotension

20
Q

This disease results in increased RBCs and blood viscosity - risk of strokes & incr BP

A

Polycythaemia rubra vera

21
Q

Amlodipine, nifedipene, felodipine are what class of drug?

A

Ca++ channel blockers

22
Q

This drug causes smooth muscle relaxation (vasodilation) by inhibiting influx of Ca++

A

Ca++ channel blockers