Angina 01.15 Flashcards
Acute Coronary Syndrome (ACS) initial treatment of MONA:
Morphine
Oxygen
Nitrates (GTN)
Aspirin
Secondary prevention of ACS - MI5 - what is this?
- Aspirin
- Clopidogrel
- Ace inhibitor
- Beta blocker
- Statin
SE of aspirin
GI irrit / bleed
Bronchospasm
Tinnitus
This drug - metabolised by CYP450 - inhibits platelet action & has similar SE to aspirin
Clopidogrel
Interactions of clopidogrel
Fluoxetine
PPIs
Enzyme inducers (carbamezapine)
SE of ace inhibitor eg ramipril
Cough
Hyperkalaemia
Renal & hepatic impairm
Interaction of ace inhibitors 2
Diuretics (-drop BP)
Nephrotoxic drugs
Beta blocker (atenolol) SE (4)
Bradycardia
Cold - raynauds
Bronchospasm
Sexual dysfunction
Interaction of beta blocker with these causes heart block
Calcium channel blockers - Verapamil & Ditiazem
Statins - SE (3)
Headache
Myalgia
Altered liver function
This drug inhibits HMG CoA Reductase, lowering LDL-C levels and enabling liver to remove LDL-C
Statins eg simvastatin
Interactions of statins
Enzyme inhibitors eg Grapefruit juice & clarithromycin
GTN releases what, which incr cGMP and causes vasodilation
Nitric Oxide
GTN s/e
Headache
Hypotension
GTN Contraindications 2
Hypotension
Aortic & mitral stenosis