Anesthetics

Question 1

Compound A

Answer 1

Product of sevoflurane interacting w/ CO2 in the respiratory machine at low rates

Question 2

Nitrous Oxide

Answer 2

Potent analgesic; weak anesthetic

ADRs: Must administer w/ at least 30% O2 or possibility of the “bends”
-Chronic exposure can also breakdown VitB12 and cause megaloblastic anemia

Question 3

Propofol-Related Infusion Syndrome

Answer 3

Fever 
Elevated Heart 
Vital Signs compromised 
Elevated enzymes 
Rhabomyolysis, Renal Failure
(looks like Malignant Hyperthermia) 

-Concurrent Alfentanil use can ppt. seizures

Question 4

Etomidate

Answer 4

Decrease blood flow to the brain =» Great for neurosurgery

Question 5

Thiopental (Spit barbiturates to make you rub your tits and shit)

Answer 5

Used for rapid sedation; recovery from this drug is due to redistribution from the brain to the periphery

-Depresses respiration, CV fnxn (like other barbiturates)

CI: PORPHYRIA

Question 6

Halothane (and other inhaled anesthetics)

Answer 6

Potent anesthetic; weak analgesic

ADRs: Vagomimetric =» Bradycardia, hypotension, decreased CO
Respiratory =» Brain decreased sensitivity to CO2

⭐️Metabolized to hepatotoxic Br- ions

***Enflurane can also cause seizures and has increased paralysis but Potentiates the effects of muscle relaxants

***Isoflurane has less ADRs

Question 7

Opioids on surgery (fentanyl mostly)

Answer 7

Used for cardiac surgeries because it preserves myocardial activity

⭐️use with Propofol can cause respiratory arrest in pediatrics tho