Anesthetics

Question 1

IV: Pharmacodynamics

Answer 1

Act on multiple neurotransmitters in ascending arousal system making pt sleepy

Question 2

IV: Pharmacokinetics

Answer 2

1. Redistribution
2. Context-Sensitive half-time
   
   • longer you infuse the drug, longer it takes to eliminate
   • bc of stores build up in peripheral compartments due to redistribution

Question 3

Propofol

Answer 3

• milk of amnesia
• Primary induction agent (IV infusion)
• Uses: general anesthesia, ICU sedation, anti-emetic
• Redistribution: 2-8 min
• Metabolism:
  
  • hepatic, renal, lungs

Question 4

IV: Dosing

Answer 4

• Drug concentration in central compartment is what matters
• Kids = larger central compartment per kilo
  
  • higher doses/kg
• Elderly = smaller central compartments per kilo
  
  • lower doses/kg