Anesthetics Flashcards
What is the natural state of Nitrous oxide when stored or delivered?
A gas, it is not a volatile liquid
- What is the rate of equilibration of Nitrous oxide? Why?
- How is this exploited therapeutically?
- Rapid. It is very insoluble in blood.
- It increases the concentration of other anesthetics and is useful to enhance induction with isoflurane, for example.
- What needs to be administered during emergence from Nitrous oxide?
- Why?
- 100% O2
- It’s rapid equilibration rate in alveoli decrease relative concentration of oxygen.
How is Nitrous oxide excreted?
99% via the lungs
- What are two clinical uses for Nitrous oxide?
- What is it not good for?
- Sedation and analgesia at 50% inhaled concentrations
- Adjunct to stronger anesthetics to reduce dose needed.
- General Anesthesia
- What is a primary contraindication for Nitrous oxide?
- What is a cardiac side effect of Nitrous oxide?
- Is respiratory suppression a major issue?
- Pneumothorax
- Negative inotrope, but sympathomimetic
- No
- What is the primary general mechanism for local anesthetics?
- What is the general resulting effect?
- They bind reversibly to a site within the pore of voltage gated Na+ channels. This blocks sodium entry when the channel is opened.
- Reversible nerve conduction blockade. This causes sensory loss and motor paralysis in innervated area.
- What is local infiltration anesthesia?
- What is nerve block anesthesia?
- Local injection of an agent irrespective of the course of cutaneous nerves
- Injection of local anesthetic around individual nerve or nerve plexus.
- What type of nerve fiber do local anesthetics act on?
- How does a local agent eliminate pain sensation?
- Is there any nerve damage that occurs with local agents?
- All nerve fibers
- Block AP initiation and propagation on nociceptive neurons.
- No, they are completely reversible.
- Where do local anesthetics bind?
- Do they bind in the uncharged or charged form?
- Are they weak acids, weak bases, strong acids or strong bases?
- On the intracellular side of the voltage-dependent sodium channel inside the channel.
- Binds in cation (charged) form
- They are all weak bases.
- How is potency measured in anesthetics?
- What is the relationship between dose of a gas and alveolar concentration?
- The “dose” of anesthetic that prevents movement in response to pain in 50% of patients
- Dose is directly related to and determined by its concentration at the alveolus.
What are three considerations of MAC (Minimum Alveolar Concentration) as a measure of anesthetic efficacy and potency?
- Measurable (concentration of anesthetic in end-tidal expired air)
- Correlates with concentration at site of action, the brain.
- End-point (lack of movement to pain) is easy to measure and define.
How is potency for IV anesthetics measured?
Free plasma concentration that produces loss of response to surgical incision in 50% of patients (EC50)
What are three likely targets of anesthetics?
- GABAA receptor Cl- channel. Results in hyperpolarization
- Inhibition of NMDA receptors. Results in reduced sodium and calcium influx. Some hyperpolarization
- Other membrane associated proteins like filling hydrophobic cavities and alteration of protein movement.
- Why do gaseous anesthetics have to be continuously administered?
- What route is typically used for induction because it is less frightening?
- They have very short half-lives.
- IV route typically used for induction.
How is rapid induction using IV anesthetic achieved?
All are hydrophobic and partition into the brain and spinal cord in one pass. Redistribution occurs when blood levels drop.
- What is Sodium thiopental?
- What is its onset of action?
- What is its duration of action?
- What is its half-life?
- A GABAA receptor agonist used to induce anesthesia
- 10-30 sec
- 10 min
- 12 hours
What is a unique about barbiturates in their side effects that can be exploited in a certain paitent population?
Since demand on the heart is reduced (which can result in precipitous drop in BP) they are not contra-indicated in patients with CAD.
- What is the mechanism for Propofol?
- What is its onset of action?
- What is its duration of action?
- What is are 2 unique side effects?
- What is the half-life?
- GABAA agonist
- 10-30 seconds (same as Sodium thiopental)
- 10 min. (same as Sodium thiopental)
- It is an antiemetic. Causes pain on injection.
- 3.5 hours (less hang-over than barbiturates)
- What needs careful monitoring during administration of Propofol?
- BP due to severe vasodilation and depression of myocardial contractility both secondary to blunted baroreflexes.
- More significant respiratory depression than thiopental.