Anesthesia Midterm Flashcards
________ monitors tell us if we are ventilating a patient, while ________ monitors tells us if we are perfusing the patient.
CO2; O2 saturation
In the OR which monitor will be the first indicator that the patient is not breathing?
CO2 monitor. Oxygen levels can remain high for a while before saturation falls but CO2 monitor will show an instantaneous change.
Phenylephrine acts on ____ receptors.
Phenylephrine is an alpha adrenergic agonist
Does phenylephrine cause venous or arterial constriction?
Both but mostly venous.
Is phenylephrine more or less potent than norepinephrine?
Less potent
Does phenylephrine last longer or shorter than norepinephrine?
Longer lasting
Is phenylephrine a direct acting or indirect acting drug?
Phenylephrine acts directly on the alpha receptors of blood vessels.
What is the typical dose of IV push phenylephrine?
50-200mcg
What is the typical dose of IV infusion phenylephrine?
20-50mcg/min
What is the effect of phenylephrine on MAP?
increase
What is the effect of phenylephrine on SBP?
increase
What is the effect of phenylephrine on DBP?
increase
What is the effect of phenylephrine on SVR?
increase
What is the effect of phenylephrine on HR?
decrease, due to baroreceptor response to increase in BP.
Why would phenylephrine decrease HR?
baroreceptor reflex responding to increase in BP.
What is the effect of phenylephrine on CO?
decrease. With higher SVR and decreased HR. CO will decrease with phenylephrine.
How is phenylephrine in the OR prepared?
By double dilution method in a 10mL syringe. or in a 100mL bag.
When we use phenylephrine or any drug that increases SVR and afterload, what should we immediately be concerned about?
Cardiac Output and afterload on the left ventricle.
Is phenylephrine a catecholamine?
No, Epinephrine, dopamine and Norepinephrine are the most abundant catecholamines in humans.
Is phenylephrine naturally occurring or synthetic?
Synthetic
Which patients would you be most concerned about increasing SVR and afterload on?
Patients with bad hearts. Or any patient over the age of 65, just assume they have some CAD.
Is ephedrine a catecholamine?
No, epinephrine, dopamine and norepinephrine are the most abundant catecholamines in humans.
Which patients would phenylephrine be best for?
patients with healthy hearts, with hypotension and high HR. Phenylephrine is good for short term use.
Is ephedrine synthetic or natural?
synthetic
Is ephedrine direct acting or indirect acting?
indirect acting
What does indirect acting mean, in regards to ephedrine?
Ephedrine acts on the storage vesicles of the neurotransmitters epinephrine and norepinephrine. it causes the body to release them into the bloodstream causing both alpha and beta effects.
Does ephedrine act on alpha or beta receptors?
Both. By causing the release of the bodies natural stores of NE and epi, both beta and alpha receptors will be affected.
What is the typical dose of ephedrine?
5-25mg
Is ephedrine given IV or IM?
either way.
What is ephedrine used to treat?
hypotension in the OR for various reasons.
Can ephedrine be used in OB anesthesia?
Yes
Can phenylephrine be used in OB anesthesia?
Yes… but this is a new idea. For purposes of boards and questions answer NO.
Ephedrine has both alpha and beta effects but which one does it effect more?
B1
Ephedrine has CV effects similar to Epinephrine but is 10x (longer acting or shorter acting)
10x longer acting
Does ephedrine affect SVR?
minimally
The CV effects of ephedrine are mostly due to?
increased contractility
What effect does ephedrine have on MAP?
increase
What effect does ephedrine have on SBP?
increase
What effect does ephedrine have on DBP?
increase
What effect does ephedrine have on HR?
increase
What effect does ephedrine have on coronary blood flow?
increase
What effect does ephedrine have on renal and splanchic blood flow?
decrease
What is a good indicator that CO has dropped?
Urine output will decrease
What is tachyphylaxis?
When a patient becomes tolerant of a drug requiring higher and higher doses to achieve the same effect.
Does ephedrine cause tachyphylaxis?
yes. Due to indirect effect and occupying of receptors.
Which gives you more predictable results: phenylephrine or ephedrine?
phenylephrine- because it acts directly on alpha receptors. ephedrine acts on vesicles with varying amounts of epi and norepinephrine stored in them so you get varying results.
Would an elderly patient tend to be more responsive or less responsive to ephedrine?
less. Because their stores of NE and epi are likely less due to aging.
Would a trauma patient tend to me more or less responsive to ephedrine?
less. Due to the fight or flight response after suffering a trauma, the NE and epi stores are depleted which would cause ephedrine to be less effective.
Would patients on tricyclic antidepressants be more or less responsive to ephedrine?
more! They have huge stores of NE and epi and may get into a situation of hypertensive crisis. Do not use ephedrine on patients on either of these two drugs.
Does ephedrine cause increased inotrophy or increased chrontrophy?
both. Because it is indirect it will affect both.
What class of drug is atropine?
anticholinergic
What is another way to think of anticholinergics?
As antiparasympathetics.
How does atropine work?
It antagonizes the effect of acetylcholine at the cholinergic, post-ganglionic muscarinic receptors.
Name 4 areas that house muscarinic receptors?
Heart, salivary glands, smooth muscles of GI, smooth muscles of GU.
does atropine have any effect on nicotinic receptors?
no, or minimal effect.
Where are nicotinic receptors found?
more in neuromuscular junction
Is atropine synthetic?
no, atropine is naturally occurring
Atropine is a _________ amine, and it________ (does, does not) cross the blood- brain barrier.
tertiary; does
Atropine is an alkaloid of __________ plant.
belladonna
What is the effect of belladonna and atropine on the pupils?
dilate (midriasis)
Atropine resembles _________ in structure.
cocaine
Does atropine have any analgesic effect?
yes, mild.
Does atropine cross the blood-brain barrier?
Yes.because it is a tertiary amine.
What is the neurological effect of atropine?
it binds to muscarinic receptors in the brain and can cause confusion, especially in the elderly. It can act as a mild sedative. It can also cause central anticholinergic syndrome which is a combination of sedation, nervousness, confusion, hallucinations, delerium and coma.
Is atropine a competitive inhibitor?
Yes. atropine combines reversibly with muscarinic receptors and prevents acH from binding to these sites.
How many muscarinic receptor subtypes are there?
5
Where are M1 receptors found?
CNS and stomach
Where are M2 receptors found?
Lungs and heart
Where are M3 receptors found?
CNS, airway smooth muscle, glandular tissue
Where are M4 and M5 receptors found?
CNS
What is the drug of choice for treating intraoperative bradycardia?
Atropine
What is the typical dose of atropine used in the OR?
15-75mcg/kg or 0.4mg-1mg
What is the effect of atropine on airway secretions?
It is an antisialagogue, it dries up secretions. But we don’t typically use atropine for this in the OR. Robinol is more commonly used for drying secretions.
What is atropine’s effects on the bronchioles?
bronchodilation
What is atropine’s effect on the pupils?
midriasis (dilates)
What is atropine’s effect on GI motility and acid production?
decreases
What is atropine’s effects on CNS?
mild sedation (not a therapeutic sedative though) and confusion, especially in the elderly.
Why is it important to dry secretions in anesthesia?
Secretions can cause laryngospasms
Name this structure.
Atropine
Name this structure.
Cocaine
What type of drug is glycopyrrolate?
Anticholinergic
The trade name for glycopyrrolate is:________
Robinol
Glycopyrrolate is a ________ amine.
Quaternary
Does glycopyrrolate cross the blood-brain barrier?
No. so it has no CNS or sedative effects. It is a quarternary amine.
In elderly patients, which would be the better drug to use for bradycardia?
Glycopyrrolate (because of less post-op confusion) unless the HR it tanking, then go for the atropine.
Which is a more potent antisialagogue: atropine or glycopyrrolate?
glycopyrrolate
Which has more potent effect on HR: atropine or glycopyrrolate?
atropine
What is the typical dose of glycopyrrolate?
0.2-0.4mg IV
How is glycopyrrolate supplied and does it require dilution?
It is supplied in 0.2mg/mL vials. It does not require dilution.
What are the 2 other common uses of glycopyrrolate?
In combination with anticholinesterases to reverse neuromuscular blockade and to dry secretions
Name a common anticholinesterase?
Neostigmine
What is the typical dose of glycopyrrolate used for reversal of neuromuscular blockade?
0.005-0.007mg/ kg or 1cc of robinol for each 1cc of reversal
Why do we bother giving glycopyrrolate with anticholinesterases to reverse neuromuscular blockade?
anticholinesterases are not selective for nicotinic receptors, they also affect acetylcholine muscarinic receptors which could slow down the HR enough to cause asystole. Because of this effect on muscarinic receptors anticholinesterases could also cause lacrimation and salivation, etc.
Why is glycopyrrolate prefered over atropine to use in combination with anticholinesterases when reversing neuromuscular blockade?
Glycopyrrolate and anticholinesterases last about the same amount of time so you don’t end up with one’s effect lasting longer or shorter than the other.
What type of drug is Succinylcholine?
A depolarizing muscle relaxant
When you hear stridor, either after extubation or around the LMA, what is the first thing you should suspect?
Laryngospasm
What is the first thing you should do to try to break laryngospasm?
Give large breaths with PPV with large pressures: 50- 60 mmHg pressures.
If giving PPV with large pressures doesn’t break laryngospasm, what is the drug of choice and what is the dose?
20mg - 40mg (adult dose) of Succinylcholine
How is Succinylcholine different from Rocuronium or Vecuronium?
Succinylcholine is a depolarizing muscle relaxant. It is the only one in it’s class. The others are not depolarizers.
What are some common complaints of patients after receiving Succinylcholine?
muscle aches or spasms
How does Succinylcholine work?
It attaches to each of the alpha subunits of the nicotinic cholinergic receptor and mimics the action of acetylcholine, depolarizing the post-junctional membrane. Hydrolysis of Succinylcholine is slower than acetylcholine so it maintains a sustained depolarization thereby inhibiting another action potential with acetylcholine, causing paralysis.
What substance clears succinylcholine from the neruomuscular junction?
pseudocholinesterases
Is there any reversal agent for succinylcholine?
No, it just takes time to be processed.
Some patients have a genetic abnormality affecting the way they metabolize succinylcholine. The test to confirm this assigns them a ________ number.
dibucaine
A dibucaine number of 20 would mean what for the patient?
They cannot break down succinylcholine
A dibucaine number of 40-50 would mean what for the patient?
That they can break down succinylcholine but they will break it down very slowly.
What is the typical dose of succinylcholine used for intubation (not the dose for laryngospasm)?
0.5- 1.5 mg/ kg (commonly 1mg/kg)
Is succinylcholine given IV or IM?
either
What is the onset of action for succinylcholine?
30-60 seconds
What is the duration of action for succinylcholine?
3-5 minutes
Name 8 side effects you might see with succinylcholine?
- dysrhythmias (bradycardia, asystole, nodal junctional rhythms, ventricular dysrhythmias) 2. hyperkalemia (due to muscle spasm) 3. Fasiculations and myalgias 4. increased GI pressure (emesis) 5. Increases ICP 6. Increased IOP 7. Masseter spasm 8. Histamine release.
What drug has been implicated as a potential triggering agent for malignant hypertension?
succinylcholine
How long does a laryngospasm dose of succinylcholine typically last?
about 2 minutes
What class of drug is Labetalol?
a non-selective beta blocker as well as alpha blocker
Does labetalol provide more beta or alpha blockade?
More beta blockade at a ratio of about 7:1
What is the usual IV dose of labetalol?
0.25 mg/kg
How frequently can you repeat doses of labetalol?
q 10 minutes
What is the typical bolus dose of labetalol?
10mg
What is the duration of action of labetolol?
2-18 hours. Genetics plays a role in how people break down labetalol, hence the wide range.
What two things should you be acutely aware of before giving labetalol?
- making sure the patient has an adequate HR, and 2. know if the patient is an asthmatic. Do not give labetalol to asthmatics.
What kind of increments should you give repeat dose of labetalol in?
give repeat doses in 2.5-5mg increments.
What type of drug is esmolol?
Beta 1 selective (at small doses)
What is the onset of action of esmolol?
2 minutes
What is the half- life of esmolol?
about 9 minutes
How is esmolol metabolized?
by non-specific plasma esterases found in the cytosol of RBCs
What is the IV bolus/ loading dose of esmolol?
500mcg/kg
In the OR, what is the typical dose of esmolol?
10-15 mg, then dose according to response.
What are the 4 main rescue drugs you should have available for every case?
Succinylcholine, Atropine, Ephedrine, and Phenylephrine
In addition to the emergency drugs you draw up, you should always have bristojets of what 4 drugs inside your cart?
Lidocaine, Epinephrine, Atropine and Calcium Chloride.
If your patient is hypotensive but tachycardic, which drug is preferred for treatment of BP: phenylephrine or ephedrine?
phenylephrine
If your asthmatic patient suddenly has hypertension in the OR, which drug would you use: labetalol or esmolol?
esmolol. Labetalol is contraindicated in asthmatics due to the risk of bronchospasm.
What other beta- blocker that is similar to esmolol,( in that it is beta 1 selective at low doses), can be used to treat hypertension?
metoprolol 2.5-5mg IV
If your elderly patient with heart disease becomes bradycardic in the OR, which drug would you use first: ephedrine or atropine?
ephedrine.
The upper airway is divided into the:
nasal passages and the oral cavity
The nasal passages include which 3 structures?
septum, turbinates, and adenoids
What function do the nasal passages serve?
humidification, filters, warms
The teeth, tongue, hard palate, and soft palate belong to which division of the upper airway?
Oral cavity
The pharynx is the area between which two structures?
the nose to the cricoid cartilige
The pharynx is divided into which 3 regions.
nasopharynx, oropharynx, and laryngopharynx
Region 1. of pharynx is the:
Nasopharynx
Region 2 of the pharynx is the:
Oropharynx
Region 3 of the pharynx is the:
laryngopharynx
Which region of the pharynx separates at the soft palate?
nasopharynx
which section of the pharynx contains the tonsils, uvula, and epiglottis?
oropharynx
Identify the regions of the larynx.
- Tongue 2. Epiglottis 3. Vocal Cords 4. Trachea 5. Esophagus
Identify the 9 areas of the airway
- Nasopharynx 2. Oropharynx 3. Tongue 4. Epiglottis 5. Laryngopharynx 6.Vocal cord 7. Larynx 8. Trachea 9. Esophagus
At which level of the spinal colum is the larynx in the adult?
C3-C6
What are the 3 functions of the larynx?
airway protection, respiration, and phonation.
Name the muscles and ligaments of the larynx. (4)
Thyroid, Cricoid, Arytenoids, epiglottis
The vocal cords are easily distinguished because they appear:
pearly white
Where do the vocal cords atttach anteriorly?
to the angles of the thyroid
Where do the vocal cords attach posteriorly?
to the arytenoids
Identify the areas of the larynx
- Superior horn of the thryroid cartilige. 2. Cricoid cartilige 3. Corniculate cartilige 4. arytenoid cartilige 5. vocal ligament 6. thyroid cartilige 7. cricoid cartilige (completion of signet ring) 8. Glottis
what do you call the triangular fissure between the vocal cords?
the glottic opening
What is the narrowest portion of the adult airway?
glottic opening
Which number represents the glottic opening? What are the other 2?
Number 2 is the glottic opening. 1. epiglottis. 3. vocal cords
How many cartiliges make up the larynx?
9 There are 3 paired and 3 unpaired
Name the 3 paired cartiliges of the larynx.
arytenoid, corniculate, and cuneiform
Name the 3 unpaired cartiliges of the larynx.
thryoid, cricoid, and epiglottis
Identify these 2 sets of paired cartiliges of the larynx
- cuneiform tubercle 2. corniculate tubercle
Identify this pair of cartiliges of the larynx
arytenoids
Identify this cartilige of the larynx.
Cricoid
What is the narrowest part of the pediatric airway?
the cricoid
the laryngeal muscles are divided into 2 subsets:
intrinsic and extrinsic
What is the difference between the intinsic and extrinsic laryngeal muscles?
intrinsic are involved with movements of the laryngeal parts (making alterations to length and tension of the vocal cords, size and shape) extrinsic are involved with moving the larynx as a whole.
All intrinsic muscles of the larynx are innvervated by the _______________ except for the cricothryoid muscle, which is supplied by the _________________
recurrent laryngeal nerve; external branch of the superior laryngeal nerve
The recurrent laryngeal nerve is a branch of which cranial nerve?
X- Vagus
The intrinsic laryngeal muscles are further divided into these two groups:
those that open and close the glottis and those that put tension on the vocal ligaments
Which 3 larygeal intrinsic muscles are responsible for opening and closing the glottis?
- lateral cricoarytenoid- adducts 2. arytenoids- adduct 3. posterior cricoarytenoids- ABduct.
The only vocal cord abductor is the:
posterior cricoarytenoid
The 3 intrinsic laryngeal muscles that put tension on the vocal ligaments are:
- cricothryroid- elongates vocal cords 2. vocalis- shortens vocal cords 3. thryroarytenoid- shortens and relaxes the vocal cords.
The 4 extrinsic laryngeal muscles are:
- Sternohyoid, 2. thryohyoid, and 3. omohyoid (these move hyoid bone caudad) and 4. Sternothyroid (moves thryoid cartilige caudad)
The trachea, carina, bronchi, bronchioles, terminal bronchioles, respiratory bronchioles, and alveoli make up the:
Lower airway
The _________ is the bifurcation of the main bronchus. It occurs at level_______ of the spinal column.
carina; T4
After the carina, the angle of the r. bronchus is:___________ and the angle of the l. bronchus is:_________. If the ETT is passed too far, it is more likely to end up in the _____ mainstem bronchus.
right- 25 degrees. left- 45 degrees. It is easier to slip too far in the right mainstem.
The two main methods of classifying an airway and identifying a difficult airway are by the:_________ and _________
Mallampati score and the Thyromental distance
What is Mallampati’s hypothesis?
When the base of the tongue is disproportionately large, the tongue overshadows the larynx resulting in difficult exosure of the vocal cords during laryngoscopy.
When assessing for Mallampati score, what position should the patient be in?
Sitting upright, head neutral, mouth open as wide as possible and tongue protruding. Do not say AHHHH.
Which Mallampati class would this airway fall into?
Class 1, faucil pillars, soft palate and uvula all clearly visible.
Which Mallampati class would this airway fall into?
Class II. Uvula is masked by tongue.
Which Mallampati class would this airway fall into?
Class III. Soft palate visible but only base of uvula.
Which Mallampati class would this airway fall into?
Class IV. only hard palate seen.
This is the expected laryngeal view for which Mallampati class?
Class I
This is the expected laryngeal view for which Mallampati class?
Class II
This is the expected laryngeal view for which Mallampati class?
Class III
This is the expected laryngeal view for which Mallampati class?
Class IV
What is meant by thryromental distance and what is the normal measurement?
Thyromental distance is the distance from the lower mandible to the thyroid notch with the neck fully extended. Normal is 6-6.5cm (about 4 fingerbreadths).
At what thyromental distance would a patient be considered a difficult intubation?
less than 3 fingerbreadths, or a receding mandible.