Anesthesia History Flashcards
What barriers where found to surgical intervention in the early years of the profession?
Pain, Infection & Blood Loss
What did ancient practices of anesthesia include?
Administration of opium poppy, cocoa leaves, mandrake root, alcohol, and phlebotomy.
How did a Greek philosopher in the 1st century A.D. defined “anesthesia”?
as a narcotic like effect caused by the mandrogara root
What was the definition of anesthesia in 1721 England?
“anesthesia” was defined as a “defect of sensation”
When was ether first introduced?
1540: Chemical structure of Ether introduced
When was nitrous oxide discovered? Who discovered nitrous oxide?
1773: N2O discovered by Joseph Priestly
N2O and O2 isolated
CO2 was the first isolated gas
Who was consider the “pioneer of chemistry”?
Joseph Priestly
Who discovered the analgesic properties of nitrous oxide? When?
1800: Humphrey Davies discovers analgesic properties of N2O
What impact did Humphrey Davies have to early anesthesia?
-Davies a student of Priestly’s
-Coined “laughing gas”
-Published the chemistry of N2O – first paragraph about decreasing pain with surgery
(Missed opportunity?)
Who is William E. Clark (Jan. 1842)?
Chemist, One obscure note in a medical journal that lacked corroboration
Who is Crawford Long (March 30, 1842)?
Surgeon/obstretician and pharmacist, Claimed to perform the first ether anesthetic, although his account was not published until 1848 in the Southern Medical and Surgical Journal
What important anesthesia history occurred in December 10, 1844?
Wells and his spouse attended a demonstration of the unique effects of N2O given by Quincy Colton.
What unique effects did Wells observe about nitrous oxide?
- A volunteer sustained a leg laceration without perceiving pain
- This phenomenon gave Wells the idea of painless dentistry
- Later his peers claimed that Wells had already experimented with N2O several years previously
Wells takes on _______as a student (both dentists)
William Morton
What important anesthesia history occurred in January 1845 with Wells and Morton?
Wells (with Morton) attempted public demonstration of a tooth extraction with N20
-Patient groaned and Morton and Wells publically ridiculed
Who identified “Letheon”?
Morton contacted surgeon John Collin Warren to say he had “Letheon” for sleep and wanted to demonstrate its merits
What did Morton plan to use Letheon for?
An operation on patient Edward Gilbert Abbott at Mass General Hospital. Successful demonstration of Letheon October 16, 1846. Applied for a patent
When was successful demonstration of letheon completed?
October 16, 1846
What is the Ether Dome?
location of the first recorded public demonstration of ether anesthesia, October 16, 1846 in the Bulfinch Building of the Massachusetts General Hospital, Fruit Street, Boston, MA
Where is the ether monument located?
The Ether Monument (1868) in the Boston Public Garden, foot of Malborough & Charles Streets.
What important anesthesia history occurred in November 4, 1847?
James Simpson, obstetrician, uses chloroform
Who was another important individual to the field of anesthesia that also used General anesthesia?
Oliver Wendell Holmes, Inhalation parties rise in popularity
What are the characteristics of chloroform (trichloromethane) (5)?
Chlorination of methane gas (sweet smelling, colorless, nonflammable): halogenated hydrocarbon
When was chloroform first prepared?
in 1831 by the American chemist Dr. Samuel Guthrie, who combined whiskey with chlorinated lime in an attempt to produce a cheap pesticide
What was chloroforms use during war time (3)?
Crimea and Spanish-American Wars and exclusively in the American Civil War
When did more physicians begin using chloroform?
Physicians began using it in civilian practice in the late 1840s and 1850s (both ether and chloroform were being used but chloroform was considered faster and non-flammable)
What is the term sudden sniffer’s death refer to?
When administered improperly, chloroform can cause cardiac arrest leading to sudden death
What led to the decrease in popularity of chloroform?
Given the concept of rendering someone unconscious was new (and “scary” for most) - the published deaths in medical journals and newspaper led to its decreased popularity in the US
What was ethers first used for?
Before used as an anesthetic was used as treatment for ailments such as scurvy or pulmonary inflammation
What are the characteristics of ether (3)?
Pleasant-smelling, colorless yet highly flammable liquid (explosive).
Ether was vaporized into a gas that ________ but left patients conscious
numbed pain
What is the organic make up of ether?
Organic compound containing carbon, hydrogen and oxygen
Why was ether considered safer to use (titrate) then chloroform?
Chloroform continued in British system of medicine - deemed too dangerous to be given by anyone than a physician; Ether/N2O predominated in the US
What is consider the basis of modern inhaled anesthetics?
Ether, Became the basis of modern inhaled anesthetics - halogenated ethers (halogenation produced less toxicity and flammability)
Who was John Snow (1813-1858) (2)?
- First to describe the states of anesthesia, created the inhaler mask and identified monitored anesthesia care (MAC)
- Popularizes obstetric anesthesia by chloroform to Queen Victoria for the birth of Prince Leopold (1853) and Princess Beatrice (1857
Who was James Thomas Clover (1825 – 1882)?
First to follow vital signs (pulse), developed jaw thrust and cricothyrotomy
Who was Sir Fredrick Hewitt (1857-1916)?
Created the airway restorer which secured the upper airway
Who was William Halstead (1852 – 1922)?
- Helped bring aseptic technique to the operating room
- Sprayed formaldehyde-like substance around to keep the surgery tent clean - caustic
- Went to Goodyear rubber company to make rubber gloves
History of Regional Block: What influential development was made in 1884 by Carl Koller?
Carl Koller, ophthalmologist, uses topical cocaine to localize the eye
History of Regional Block: What influential development was made in 1884 by William Halsted ?
administered first nerve block with injectable cocaine
History of Regional Block: What influential development was made in 1898?
August Bier administered first spinal (0.5% cocaine, 3ml)
History of Regional Block: What influential development was made in 1908?
Caudal block & Bier block developed
History of Regional Block: What influential development was made in 1921?
Lumbar epidural performed by Fidel Pages
History of IV agents: What influential development was made in 1805?
Morphine isolated (High mortality because of large doses)
What is morphine associated with in early periods of use?
High mortality because of large doses
History of IV agents: What influential development was made in 1903?
Barbiturates synthesized by Fischer and Von Mering