anemia drugs

Question 1

treatment for iron def

Answer 1

ferrous sulfate

ferrous gluconate

ferrous fumarate

iron dextran = parenteral iron

Question 2

deferoxamine

Answer 2

treatment for acute iron tox - it chelates iron

Question 3

cyanocobalamin

Answer 3

therapeutic vit B12

nasal, oral, parenterally (this is how its usually given)

prefered for long term use becuase it doesnt cause antibody response like in other agents

Question 4

hydroxocobalmin

Answer 4

therapeutic vit B12

higly protein bound and remians in circ longer

some patienst produce antibodies to this bound to proteins in the blood (transcobalamin2)

Question 5

treatment for normocytic anemia

Answer 5

erythropoietin

Question 6

treatment for folic acid def

Answer 6

folic acid

leucovorin

Question 7

epoetin alpha (erythorpoeitin)

Answer 7

stimulates red cell production, reticulocyte release

used in anemia pateints with chronic renal failure,HIV infection, or cancer patients getting chemo

adverse effects = hypertension, thrombosis

Question 8

filgrastim (G-CSF)

Answer 8

use in a stem cell donor to mobilize stem cells for harvest

stimulates granulocytes

prevents and treats cytotoxic chemotherapy related neutropeai

reduces time to engraftment after autologous stem cell transplant

Question 9

sargramostim (GM-CSF)

Answer 9

uses similar to filgrastim (G-CSF)

adverse effects are common: fever, malaise, arthralgia, myalgia, capillary leak syndrome (peripheral edema, pleural and pericardial effusions)

Question 10

oprelvekin (IL-11)

Answer 10

promotes megakaryopoiesis

increases platlet numbers

used in pateinst recieaving cytotoxic chemo