Anemia, Cytopenias And Thrombosis Flashcards

1
Q

3 typical signs or symptoms of acute anemia.

A
  1. Tachycardia
  2. Orthostatic hypotension
  3. Dyspnea
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2
Q

List 9 typical symptoms of a chronic drop in hgb.

A
  1. Fatigue
  2. Decreased appetite
  3. Decreased exercise capacity
  4. Dizziness
  5. Headache
  6. Syncope
  7. Tinnitus
  8. Vertigo
  9. Impaired cognitive function
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3
Q

List 7 disease related causes of anemia in palliative care.

A
  1. Bone marrow infiltration
  2. Blood loss
  3. Hemolysis
  4. Anemia of chronic disease
  5. Cancer treatments
  6. Folate deficiency from malnutrition
  7. GI resections.
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4
Q

List two cancer treatment related causes of anemia.

A
  1. Myelosuppression from chemotherapy.

2. Treatment related myelodysplastic syndrome.

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5
Q

What are the red blood cell features of normocytic anemia?

A

Normocytic, normochromatic

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6
Q

Which cancers are commonly associated with hemorrhage? (9)

A
  1. GI
  2. Head and neck
  3. Respiratory
  4. Uterine
  5. Urinary
  6. Bulky sarcomas
  7. Hepatomas
  8. Melanomas
  9. Ovarian cancers
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7
Q

List 3 non pharm ways to control bleeding.

A
  1. Surgically
  2. Endoscopically
  3. Radiation
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8
Q

What is the usual dose of parenteral iron per day for adults?

A

150-200mg of elemental iron a day

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9
Q

List 4 common side effects of po iron.

A
  1. Nausea
  2. Diarrhea
  3. Heartburn
  4. Constipation
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10
Q

List 3 indications for parenteral iron.

A
  1. Intolerant of oral iron
  2. Intestinal absorption issues
  3. Losing iron more quickly than it can be replaced orally.
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11
Q

List 6 common side effects of parenteral iron.

A
  1. Hypotension
  2. Cramps
  3. Nausea
  4. Vomiting
  5. Headaches
  6. Diarrhea
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12
Q

What is the recommended dietary intake of folic acid?

A

0.4mg per day

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13
Q

List 3 cancers commonly associated with bone marrow infiltration.

A
  1. Lung
  2. Breast
  3. Prostate
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14
Q

What are 4 common biochemical signs of bone marrow infiltration from malignancy?

A
  1. Leucoerythroblastic blood
  2. Presence of immature nucleated red cells
  3. Myeloid white cell precursors
  4. Teardrop shaped red cells
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15
Q

What CBC pattern is common in bone marrow infiltration from solid tumours? (3)

A
  1. Elevated WBC
  2. Low hgb
  3. Low, normal or elevated plts
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16
Q

List 3 causes of neutropenia in palliative care.

A
  1. Myelosuppressive chemotx
  2. Disease infiltration of the bone marrow
  3. Intrinsic bone marrow failure
17
Q

Definition of neutropenia

A

ANC < 1500 cells/microlitre

18
Q

Define severe neutropenia

A

ANC < 500 cells/microlitre