Anemia and Red Cell Disorders-Usera Flashcards
What is the production of RBCs in bone marrow?
erythropoiesis
Erythropoiesis is stimulated by (blank) release by interstitial cells in peritubular capillaries of renal cortex
EPO
What is the stimuli for EPO release?
Hypoexemia
Anemia
Left shift of oxygen binding curve
How can you increase (left shift binding curve) oxygen binding affinity?
Increased pH
decreased DPG
decreased Temp
How do you right shift the oxygen binding curve (i.e get rid of oxygen easily)?
decrease pH
increase DPG
increase temp
What are reticulocytes a sign of?
active erythropoiesis
Thread-like RNA filaments become mature RBC in (blank) hours
24 hours
How is reticulocyte count recorded?
as a % of normal (normal less than 3%)
What is falsely increased in anemic states?
reticulocyte count (must be corrrected for)
How do you correct for reticulocyte count in anemic states?
Corrected Count = (actual Hct/45) x Retic count
(blank) requires additional correction beyond this Corrected Count = (actual Hct/45) x Retic count
…. what is it?
Polychromasia
you divide corrected count by 2
Extramedullary hemaotpoiesis (EMH) is naturally present in (Blank) and (Blank) -liver and spleen
babies and young children
What is the compensatory response to anemia?
- hepatosplenomegaly
- bone marrow expansion in active marrow
If you see accelerated erythropoiesis what should you be thinking about?
polycytotheia vera, anemia
If you have hyperstimulation of bone marrow how will this present in children?
How about in adults?
hepatosplenomegaly
In their bones
If you order a CBC and there is no comment on morphology what does this mean?
this means there is nothing wrong
What are the measured variables provided by a CBC?
Hemoglobin, Hct, RBC count
What is a calculated variable provided by a CBC?
RBC indices
WHat else will a CBC provide that is not measured nor calculated?
WBC count with diff
Platelet count
morphology
Newbons have (lower/higher) ranges of hemogloin thatn children and infants
higher
What is this
HbF (2a2y)-shifts OBC to the left
fetal hemoglobin
Over (blank) months, fetal hemoglobin cels are replaces by HbA (97%), HbA2 (2.5%) and HbF (less than 1%)
6-9
Why can you get physiologic jaundice of newborn?
Fetal RBC with HbF are destroyed by splenic macrophages. This leads to elevations of unconjugated bilirubin.
Children have (higher/lower) hemoglobin than adults…. why?
lower
Cuz they have higher phosphors levels that increase synthesis of 2,3 DPG leading to righ shifted OBC