anemia

Question 1

Is TIBC high or low for Fe deficiency anemia?

Answer 1

High.

low in Iron concentration, so bind like hell

Question 2

Is retic high or low for Fe deficiency anemia?

Answer 2

Low.

body should compensate and go high but youre deficient so you cant

Question 3

Is Transferrin sat and ferritin high or low for Fe deficiency anemia?

Answer 3

Transferrin Low
Ferritin low

Transferrin typically binds at higher capacity when Fe is low so it can bind more iron. But Transferrin sat measures the % of iron binding sites on transferrin that are occupied by iron

Ferritin: cant store nothing

Question 4

Is retic high or low for anemia of chronic diseases?

Answer 4

Low

-bone marrow is affected

Question 5

Is serum Fe high or low for anemia of chronic diseases?

Answer 5

low
-inflammation causes IL-6 -> liver produces high lvl hepcidin -> decreases ferroportin -> decreases iron absorption-> low serum iron > low hb

*note serum Fe is always low except for Sideroblastic, where the defect is in mito and you cant incorporate Fe into Hb.

Question 6

Is Transferrin and Ferritin high or low for anemia of chronic diseases?

Answer 6

Transferrin low

Ferritin very high
-you are not deficient in Fe, so you can store it

Question 7

In microcytic non hemolytic anemias, which values are most important to note?

Answer 7

TIBC
- high for Fe deficiency
Ferritin
- High for Anemia of chronic

Question 8

Is retic high or low for lead intoxication anemia?

Answer 8

Low
-Lead inhibits the body’s ability to make hemoglobin by interfering with several enzymatic steps in the heme pathway. ( lead decreases heme biosynthesis)

Question 9

In microcytic hemolytic anemias (HS and T) is retic high or low?

Answer 9

High

- overcompensating bc you are lysing too much (membrane shitty), so you make much

Question 10

What value is different between hemolytic anemias?

Answer 10

MCHC
high for HS and AIHA
variable for G6PD
low for all the rest

Question 11

Is Biliruben and LDH high or low for HS and THal?

Answer 11

High

RBC rupturing->released hb converted to unconjugated bili-> high bili

when RBC lysed, LDH comes out

Question 12

Is retic high or low for all hemolytic anemias?

Answer 12

High

– overcompensating bc you are lysing too much (membrane shitty), so you make much

Question 13

Is Biliruben and LDH high or low for all hemolytic anemia?

Answer 13

high

RBC rupturing->released hb converted to unconjugated bili-> high bili

when RBC lysed, LDH comes out

Question 14

What does hemodsiderin in urine indicate?

Answer 14

intravascular hemolysis

Question 15

Which values are typically high for sideroblastic anemia?

Answer 15

Serum Fe
-adequate iron is present, a mitochondrial defect prevents the incorporation of iron into hemoglobin.

Transferrin

Ferritin

Question 16

What values are low for sideroblastic anemia?

Answer 16

MCV

Retic
-Low retick: decreased synthesis and increased destruction of RBCs in marrow

TIBC
-Low TIBC: you have enough iron, but mitochondrial defect prevents enzyme that encorporates iron into Hb

Question 17

High creatine levels indicate what?

Answer 17

bad kidneys

higher creatinine value = worse the kidney (kidney usually filters out creatinine which is a waste product of metabolism)

Question 18

No retic response to EPO may indicate what?

Answer 18

lack of iron stores

-Want retic to go up when you give EPO (repair anemia) sometimes we unmask iron deficiency when we give EPO sometimes.

Question 19

High TIBC indicates what?

Answer 19

lower iron stores

Question 20

Antibody coating of platelets can cause what?

Answer 20

Thrombocytopenia - spleen takes them out

Question 21

Seeing Iron in BM is gold standard for what?

Answer 21

Hemolytic anemia

Question 22

relationship between hematocrit and EPO

Answer 22

Higher the hematocrit the lower the EPO if kidney is working right. Inverse relationship

Question 23

Polychromasia

Answer 23

(big, fat, blue-colored cells representing reticulocytes) - different coloring of cells - sign of retics

Question 24

In anemia of chronic disease, which is the only value that is high?

Answer 24

ferritin
-high keep away from bad guys
you arent deficient in iron, you just cant absorb it bc of hepcidin