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Andropause Flashcards

1
Q

Andropause is best described as:

A. Slow decline of testosterone at age 40
B. Slow decline of testosterone starting age 60
C. Rapid decline of testosterone from age 50
D. Rapid decline of testosterone from age 70

A

A

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2
Q

The following cells are responsible for secreting testosterone

A. Seminiferous tubules
B. Sertoli Cells
C. Leydig cells
D. prostatic epithelium

A

C

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3
Q

The active intracellular androgenic hormone is

A. Testosterone
B. Androstenedione
C. Dehydroepiandrostenedione
D. Dihydrotestosterone

A

D

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4
Q

Testosterone is generally unavailable to the cells since most of it is bound to

A. Albumin
B. Beta globulin
C. sex hormone binding protein
D. gamma globulin

A

C

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5
Q

The following are manifestations of hypogonadism except

A. Diminished sexual desire
B. Loss of visceral fat
C. Osteoporosis
D. Loss of muscle volume

A

B

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6
Q

Blood exam for testosterone testing is best done

A. in the morning
B. afternoon
C. early evening
D. Anytime

A

A

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7
Q

Metabolic syndrome in men is central obesity of >90 cm waist circumference and

A. Triglycerides of 1.5 mmol/L
B. BP of 110/75mm Hg
C. FBS of 5.0 mmol/L
D. HDL of 90 mmol/L

A

D

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8
Q

Metabolic syndrome is mainly a complex association of abnormalities on low testosterone and insulin resistance which increase the risk for

A. Prostate cancer
B. Heart disease
C. hepatitis
D. dementia

A

B

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9
Q

Before starting treatment for hypogonadism, the clinician must make sure that the patient must be clear of:

A. Heart disease
B. diabetes mellitus
C. Prostate cancer
D. hypertension

A

C

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10
Q

Testosterone can be given safely. One preparation which must not be prescribed due to liver toxicity

A. cyprionate prep
B. alkylated forms
C. emanthate prep
D. intramuscular preparations

A

B

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11
Q

The process of erection is a neurovascular event which requires

A. Smooth muscle relaxation of arteries and constriction of the subtunical veins

B. Smooth muscle relaxation of the arteries and the subtunical veins

C. Smooth muscle contraction of the sinusoids and the relaxation of the subtunical veins

D. Smooth muscle contraction of the sinusoids and the subtunical veins

A

A

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12
Q

Erectile dysfunction is a condition that is affected adversely by the following

A. Smoking, cycling, DM
B. Alcohol, age and liver problem
C. Diabetes, hypertension, age
D. hypertension, hyperthyroidism, age

A

C

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13
Q

The first line of treatment for erectile dysfunction in the last decade is

A. Aromatase inhibitorss
B. Phosphodiesterase 5 inhibitors
C. 5-alpha reductase inhibitors
D. 17 hydroxylase inhibitors

A

B

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14
Q

The enzyme responsible for smooth muscle relaxation if the arterial smooth muscle is

A. Guanosine triphosphate (GTP)
B. 5 guanosine monophosphate (%GMP)
C. cyclic aminosine monophosphate (CAMP)
D. cyclic guanosine monophosphate (cGMP)

A

D

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15
Q

The most contraindicated drug that must not be taken with sildenafil is

A. antihypertensives
B. anti diabetic drugs
C. nitrates
D. alpha reductase inhibitors

A

C

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16
Q

The slow decline of androgen production begins at approximately what age?

17
Q

What are the two main androgens?

A

Testosterone and dihydrotestosterone

18
Q

What percent of testosterone affects the testosterone action?

19
Q

Andropause (decreases/increases) lean body mas, muscle volume and strength.

20
Q

Andropause (decreases/increases) body hair and skin alterations.

21
Q

Andropause (inhibits/stimulates) development of gynecomastia.

A

Stimulates

22
Q

Andropause (decreases/increases) visceral fat.

23
Q

Andropause (decreases/increases) bone mineral density.

24
Q

Andropause (diminishes/enhances) sexual desire, erectile quality and quality of orgasms and ejaculation.

A

Diminishes

25
Q

Testosterone (increases/decreases) nitrogen retention.

26
Q

Testosterone (increases/decreases) protein synthesis.

27
Q

PSA >4ng/ml. : absolute or relative contraindication to testosterone supplementation?

28
Q

Abnormal DRE findings: absolute or relative contraindication to testosterone supplementation?

29
Q

Snoring: absolute or relative contraindication to testosterone supplementation?

30
Q

Polycythemia: absolute or relative contraindication to testosterone supplementation?

31
Q

Respiratory difficulties: absolute or relative contraindication to testosterone supplementation?

32
Q

LUTS: absolute or relative contraindication to testosterone supplementation?

33
Q

Hyperlipidemia: absolute or relative contraindication to testosterone supplementation?

34
Q

Severe cardiac insufficiency: absolute or relative contraindication to testosterone supplementation?

35
Q

Which one has the longest half-life?

A. Sildenafil
B. Tadalafil
C. Vardenafil

Geriatrics (4 decks)

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