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T&D IV exam 4 > Androgen drugs > Flashcards

Androgen drugs Flashcards

1
Q

What route is testosterone admn?

A

IM/transdermal

NOT oral

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2
Q

what are testosterone esters

A

testosterone cypionate and enanthate

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3
Q

Orally effective testosterone

A

17a-alkylated testosterone

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4
Q

examples of 17a-alkylated testosterone

A

Methyltestosterone
Fluoxymesterone
Stanazolol (derivative)

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5
Q

Greatest risk of hepatotoxicity

association with jaundice

A

Methyltestosterone

Fluoxymesterone

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6
Q

MOA

Danazol

A

depress the preovulatory surge in output of FSH and LH –> reduction in ovarian estrogen and progesterone production , supressed midcycle surge leading to anovulation

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7
Q

Used for endometriosis

A

Danazol

Leuprolide

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8
Q

synthetic testosterone derivative with high anabolic to androgenic ratio

A

Oxandrolone

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9
Q

use of oxandrolone

A

weight gain in ptns who cannot gain weight

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10
Q

Antiandrogens

A

Finasteride
Dutasteride
Leuprolide
Fltuamide

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11
Q

MOA

Finasteride, dutasteride

A

reduce levels of DHT by inhibiting 5a-reductase (conversion of testosterone to DHT)

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12
Q

Which antiandrogen is selective for type 2 5a-reductase

A

Finasteride

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13
Q

a1-adrenergic receptor inhibitors

A

Tamsulosin

Alfuzosin

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14
Q

MOA

Tamsulosin/Alfuzosin

A

decrease smooth muscle tone in the prostate and bladder neck

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15
Q

Do a1-adrenergic receptor inhibitors adress the cause of BPH?

A

no

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16
Q

ADR antiandorgens

A

gynecomastia

lower PSA levels in males

17
Q

moa Leuprolide

A

GnRH agonist –> down regulation of LH and FSH, decreased levels of circulating testosterone in males

18
Q

Elevated liver function test and gynecomastia

A

Fltuamide

19
Q

used for benign prostatic hyperplasia

A

Finasteride, Dutasteride

20
Q

used for prostatic cancer

A

Leuprolide

Fltuamide

21
Q

Contraindicated for prostate cancer

A

Stanazolol
Oxandrolone
17a-alkylated testosterone (methyltestosterone, fluoxymesterone)

22
Q

Contraindications for all testosterone analogs

A

Prostate cancer
Male breast cancer
Pregnancy

23
Q

Increases mRNA levels and protein levels of C1 INH and C4… used for?

A

Stanazolol

used for hereditary angioedema

T&D IV exam 4 (1 decks)

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