Anatomy - sidebyside Flashcards

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1
Q

Define anisocytosis.

A

varying cell sizes

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2
Q

Defi ne poikilocytosis

A

varying cell shapes

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3
Q

From which cells do B cells

arise?

A

stem cells in bone marrow

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4
Q

From which cells do plasma

cells differentiate?

A

B cells

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5
Q

How can a Nissl stain be used
to differentiate microglia
from oligodendroglia?

A
Microglia are not discernable 
in a Nissl stain while 
oligodendroglia appear as 
small dark nuclei with dark 
chromatin
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6
Q

In what type of CNS tissue
(white or grey) are
oligodendroglia predominant?

A

white matter

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7
Q

Into what cell type does a
monocyte differentiate in
tissues?

A

Macrophages

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8
Q

Name 2 substances produced

by an eosinophil.

A

histiminase and arylsulfatase

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9
Q

Name the three types of

leukocytic granulocytes.

A

basophils, eosinophils, and

neutrophils

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10
Q

Name the two types of

mononuclear leukocytes.

A

lymphocytes and monocytes

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11
Q

What are 2 functions of T cell

lymphocytes?

A
  • cellular immune response -
    regulation of B lymphocytes
    and macrophages
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12
Q

What are 2 morphological

features of microglia?

A
  • small irregular nuclei - and

relatively little cytoplasm

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13
Q

What are 3 examples of

peripheral lymphoid tissue?

A
  • follicles of lymph nodes -
    white pulp of spleen -
    unencapsulated lymphoid
    tissue
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14
Q

What are 3 functions of a

macrophage?

A
- pagocytosis of bacteria, 
cell debris, and senescent red 
cells - scavenges damaged 
cells and tissues - can 
function as an antigen 
presenting cell
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15
Q

What are 3 morphological

characteristics of monocytes?

A
  • Large - Kidney-shaped
    nucleus - Extensive ‘frosted
    glass’ cytoplasm
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16
Q

What are 4 characteristics of

the plasma cell morphology?

A
  • Off center nucleus - Clock
    face chromatin distribution -
    Abundant RER - Well
    developed Golgi apparatus
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17
Q

What are 4 morphologic
characteristics of
lymphocytes?

A
  • Round - Small - Densely
    staining nucleus - Small
    amount of pale cytoplasm
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18
Q

What are 4 substances
contained within the
lysosomes of neutrophils?

A
  • hydrolytic enzymes -
    lysozyme - myeloperoxidase
  • lactoferrin
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19
Q

What are 4 types of cells into

which T cells di! erentiate?

A
- cytotoxic T cells (MHC I, 
CD8) - helper T cells (MHCII, 
CD4) - suppressor T cells - 
delayed hypersensitivity T 
cells
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20
Q

What are the 5 important
causes for eosinophilia in
humans?

A

Neoplastic, Asthma, Allergic
process, Collagen vascular
disease, and Parasites
(pneumonic NAACP)

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21
Q
What are the blood cell 
di !enentiation names of the 
ACTIVE T CELL line beginning
with the pluripotent 
hematopoietic stem cell? (4)
A
  • Pluripotent hematopoietic
    stem cell - Lymphoblast - T
    cell - Active T cell
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22
Q
What are the blood cell 
di !erentiation names of the 
ERYTHROCYTE cell line 
beginning with pluripotent 
hematopoietic stem cell? (4)
A
  • Pluripotent hematopoietic
    stem cell - Proerythroblast -
    Reticulocyte - Erythrocyte
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23
Q
What are the blood cell 
di !erentiation names of the 
MONOCYTE cell lines 
beginning with the 
pluripotent hematopoietic 
stem cell? (3)
A
  • Pluripotent hematopoietic
    stem cell - Mono blast -
    Monocyte
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24
Q
What are the blood cell 
di !erentiation names of the 
NEUTROPHIL, EOSINOPHIL, 
and BASOPHIL cell lines 
beginning with the 
myeloblast stage? (6)
A
  • Myeloblast - Promyelocyte
  • Myelocyte - Metamyelocyte
  • Stab cell - Neutrophil,
    eosinophil or basophil
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25
Q
What are the blood cell 
di !erentiation names of the 
PLASMA CELL line beginning
with the pluripotent 
hematopoietic stem cell? (4)
A
  • Pluripotent hematopoietic
    stem cell - Lymphoblast - B
    cell - Plasma cell
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26
Q
What are the blood cell 
di !erentiation names of the 
PLATELET CELL line beginning
with the hematopoietic stem 
cell? (4)
A
  • Pluripotento hematopoietic
    stem cell - Megakaryoblast -
    Megakaryocyte - Platelets
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27
Q

What are the components of

the air-blood barrier?

A
  • Type I pneumocyte - tight

junction - endothelial cell

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28
Q

What are the steps of
maturation of a B cell? (2
points)

A
  • maturation in the marrow -
    migration to peripheral
    lymphoid tissue
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29
Q

What are the substances
contained within the densly
basophilic granules of the
basophil? (4)

A
- Heparin (anticoagulant) -
histamine (vasodilator) - 
vasoactive amines - Slow 
reacting substance of 
anaphylaxis
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30
Q

What are two basic
morphological characteristics
of neutrophils?

A
  • multilobed nucleus - large,
    spherical azurophilic primary
    granules (lysosomes)
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31
Q

What are two important

functions of a neutrophil?

A
  • acute infl ammmatory
    response of a cell -
    phagocytosis
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32
Q

What are two names for an
increased number of red
cells?

A

Erythrocytosis and

polycythemia

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33
Q

What cell type closely

resembles a mast cell?

A

basophil

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34
Q

What cranial nerves are
commonly involved in an
acoustic neuroma?

A

CN VII, VIII (association with

internal acoustic meatus)

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35
Q

What disease is characterized
by destruction of
oligodendroglia?

A

Multiple sclerosis

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36
Q

What does CD stand for?

A

cluster of di ! Erentiation

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37
Q

What drug prevents mast cell

degranulation?

A

What drug prevents mast cell

degranulation?

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38
Q

What immunoglobulin can
bind to the membrane of a
mast cell?

A

IgE

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39
Q

What is a reticulocyte?

A

What is a reticulocyte?

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40
Q

What is an important example

of a Schwannoma?

A

Acoustic neuroma

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41
Q

What is another name for

pulmonary sufractant?

A

DPPC

dipalmitoylphosphatidylcholine

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42
Q

What is percentage of
leukocytes in the blood exist
as basophils?

A

less than 1%

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43
Q

What is the ‘gap’ between the
myelination segment of 2
Schwann cells called?

A

Node of Ranvier

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44
Q

What is the advantage of the
large surface area:volume
ratio in erythrocytes?

A

easy gas exchange (Oxygen

and Carbon dioxide)

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45
Q

What is the basic morphologic

structure of an erythrocyte?

A

Anucleate, biconcave

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46
Q

What is the basic morphology

of an eosinophil? (2 things)

A
  • bilobate nucleus - packed
    with large eosinophilic
    granules of uniform size
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47
Q

What is the embryologic

origin of microglia?

A

mesoderm

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48
Q

I miss u so much~

A

kiss my dear bear~

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49
Q

What is the function of
Interferon gamma with
relation to macrophages?

A

macrophage activation

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50
Q

What is the function of

microglia?

A

phagocytosis in CNS

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51
Q

What is the function of

oligodendroglia?

A

myelination of multiple CNS

axons

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52
Q

What is the function of

pulmonary surfactant?

A

lowers alveolar surface
tension and prevents
atelectasis

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53
Q

What is the function of

Schwann cells?

A

myelination of PNS (a
Schwann cell myelinates only
one PNS axon)

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54
Q

What is the importance of the

lecithin:sphingomyelin ratio?

A

> 2.0 in fetal lung is
indicative of fetal lung
maturity

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55
Q

What is the importance of the
physiologic chloride shift in
erythrocytes?

A
Membranes contain the 
chloride bicarbonate antiport 
allowing the RBC to transport 
carbon dioxide from the the 
lung periphery for 
elimination.
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56
Q

What is the last segment of
lung tissue in which ciliated
cells are found?

A

respiratory bronchioles

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57
Q

What is the last segment of
lung tissue in which goblet
cells are found?

A
terminal broncioles 
(remember ciliated cells 
sweep away mucous 
produced by goblet cells and 
therefore run deeper)
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58
Q

What is the primary function

of a basophil?

A

Mediates allergic reactions

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59
Q

What is the primary function

of a leukocyte?

A

Defense against infections

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60
Q

What is the primary function

of a mast cell?

A

Mediates allergic reactions

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61
Q

What is the primary function

of a plasma cell?

A

production of large amounts
of a specific antibody to a
particular antigen

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62
Q

What is the primary source of

energy for erythrocytes?

A

glucose (90% anaerobically
degraded to lactate, 10% by
HMP shunt)

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63
Q

What is the process of

degranulation in mast cells?

A

release of histamine, heparin,
and eosinophil chemotactic
factors

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64
Q

What is the range of
concentration for leukocytes
in the blood?

A

4,000 - 10,000 cells per

microliter

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65
Q

What is the response of an
eosiniphil to antigen antibody
complexes?

A

high degree of phagocytosis

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66
Q

What is the response of

microglia to tissue dammage?

A

transformation into large

ameboid phagocytic cells

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67
Q

What is the response to

microglia infected with HIV?

A

fusion to form multinucleated

giant cells in CNS

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68
Q

What is the survival time for

an erythrocyte?

A

120 days

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69
Q

What pathognomonic change
is seen in neutrophils of a
person who is folate/vitamin
B12 defi cient?

A

hypersegmented polys

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70
Q

hypersegmented polys

A

1 - 6%

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71
Q

What percentage of
leukocytes exist as
neutrophils in the blood?

A

40 - 75%

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72
Q

What percentage of
leukocytes in blood are
monocytes?

A

2 - 10%

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73
Q

What process occurs when
type I pneumocytes are
damaged?

A

Type II pneumocytes develop

into type I

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74
Q
What substance in 
eosinophilic granules is 
primarily responsible for 
defense against helminths 
and protozoan infections?
A

major basic protein

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75
Q

Where is the site of

maturation of T lymphocytes?

A

Thymus

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76
Q

Which cell type constituitively
secretes pulmonary
surfactant?

A

Type II pneumocyte

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77
Q

Which cell type lines the

alveoli?

A

Type I pneumocyte

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78
Q

Which leukemia is the result

of plasma cell neoplasm?

A

Multiple myeloma

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79
Q

Which type of hypersensitivity
reaction is a mast cell
involved in?

A

Type I hypersensitivity

reaction

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80
Q

Which type of immunity do B

cells exhibit?

A

humoral immunity

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81
Q

After arising from the floor of
the primitive pharynx, where
does the thryoid diverticulum
go?

A

It descends down into the

neck

82
Q

After the first breath at birth,
what causes closure of the
ductus arteriosus?

A

An increase in oxygen

83
Q

After the first breath at birth,
what causes the closure of
the foramen ovale?

A

A decrease resistance in
pulmonary vasculature causes
increased left atrial pressure
vs. right atrial pressure

84
Q

Although the diaphragm
descends during
development, it maintains
innervation from ____?

A

C3-C5

85
Q

An easy pneumonic to
remember fetal erythropoiesis
is?

A

Young Liver Synthesizes

Blood

86
Q

At what time in the course of
development is the fetus
most susceptible to
teratogens?

A

Weeks 3-8

87
Q
Deoxygenated blood from the
SVC is expelled into the 
pulmonary artery and \_\_\_\_ 
\_\_\_\_ to the lower body of the 
fetus.
A

ductus arteriosus

88
Q

Do the cardiovascular
structures arise from neural
crest (ectoderm), mesoderm,
or endoderm?

A

Mesoderm

89
Q

Do the chroma” n cells of the
adrenal medulla arise from
neural crest (ectoderm),
mesoderm, or endoderm?

A

Neural Crest (Ectoderm)

90
Q

Do the enterochroma” n cells
arise from neural crest
(ectoderm), mesoderm, or
endoderm?

A

Neural Crest (Ectoderm)

91
Q
Do the lungs arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Endoderm

92
Q
Do the lymphatics arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Mesoderm

93
Q

Do the melanocytes arise
from neural crest (ectoderm),
mesoderm, or endoderm?

A

Neural Crest (Ectoderm)

94
Q

Do the neural crest cells arise
from mesoderm, ectoderm, or
endoderm?

A

Ectoderm

95
Q

Do the odontoblasts arise
from neural crest (ectoderm),
mesoderm, or endoderm?

A

Neural Crest (Ectoderm)

96
Q

Do the parafollicular (C) cells
of the thyroid arise from
neural crest (ectoderm),
mesoderm, or endoderm?

A

Neural Crest (Ectoderm)

97
Q

Do the Schwann cells arise
from neural crest (ectoderm),
mesoderm, or endoderm?

A

Neural Crest (Ectoderm)

98
Q

Do the urogenital structures
arise from neural crest
(ectoderm), mesoderm, or
endoderm?

A

Mesoderm

99
Q

Does blood arise from neural
crest (ectoderm), mesoderm,
or endoderm?

A

Mesoderm

100
Q

Does bone arise from neural
crest (ectoderm), mesoderm,
or endoderm?

A

Mesoderm

101
Q
Does muscle arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Mesoderm

102
Q

Pat pat~

A

Everyhing’ll be just fine~

103
Q
Does the  thyroid arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Endoderm

104
Q

Does the adrenal cortex arise
from neural crest (ectoderm),
mesoderm, or endoderm?

A

Mesoderm

105
Q
Does the ANS arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Neural Crest (Ectoderm)

106
Q

Does the celiac ganglion arise
from neural crest (ectoderm),
mesoderm, or endoderm?

A

Neural Crest (Ectoderm)

107
Q

Does the dorsal root ganglion
arise from neural crest
(ectoderm), mesoderm, or
endoderm?

A

Neural Crest (Ectoderm)

108
Q

Does the dura connective
tissue arise from neural crest
(ectoderm), mesoderm, or
endoderm?

A

Mesoderm

109
Q

Does the gut tube epithelium
arise from neural crest
(ectoderm), mesoderm, or
endoderm?

A

Endoderm

110
Q
Does the liver arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Endoderm

111
Q
Does the pancreas arise from
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Endoderm

112
Q

Does the parathyroid arise
from neural crest (ectoderm),
mesoderm, or endoderm?

A

Endoderm

113
Q
Does the pia arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Neural Crest (Ectoderm)

114
Q

Does the serous linings of
body cavities arise from
neural crest (ectoderm),
mesoderm, or endoderm?

A

Mesoderm

115
Q
Does the spleen arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Mesoderm

116
Q
Does the thymus arise from 
neural crest (ectoderm), 
mesoderm, or endoderm?
A

Endoderm

117
Q

From what does the
ligamentum teres hepatis
arise?

A

Umbilical vein

118
Q

How does a bicornate uterus

form?

A

Results from incomplete
fusion of the
paramesonephric ducts

119
Q

How does a cleft lip form?

A

Failure of fusion of the
maxillary and medial nasal
processes

120
Q

How does a cleft palate form?

A

Failure of fusion of the lateral
palatine processes, the nasal
septum, and/or the median
palatine process

121
Q

How does a horseshoe kidney

form?

A
Inferior poles of both kidneys
fuse, as they ascend from the
pelvis during development 
they get trapped under the 
inferior mesenteric artery, 
and remain low in the 
abdomen
122
Q

How is meckel’s diverticulum
di !erent than an
omphalomesenteric cyst?

A

Omphalomesenteric cyst is a
cystic dilatation of the
vitelline duct

123
Q

How long does full
development of
spermatogenesis take?

A

2 months

124
Q

How many arteries and veins
does the umbilical cord
contain?

A

—2 umbilical arteries (carries
deoxygenated blood away
from fetus) - 1 umbilical vein
(oxygenated blood to fetus)

125
Q

Is a primary spermatocyte 2N

or 4N?

A

4N

126
Q

Is a primary spermatocyte

haploid or diploid?

A

Diploid, 4N

127
Q

Is a secondary spermatocyte

haploid or diploid?

A

Haploid, 2N

128
Q

Is a secondary spermatocyte

N or 2N?

A

2N

129
Q

Is a speratogonium haploid or

diploid?

A

Diploid, 2N

130
Q

Is a spermatid haploid or

diploid?

A

Haploid, N

131
Q

Meiosis I is arrested in which

phase until ovulation?

A

Prophase

132
Q

Meiosis II is arrested in which

phase until fertilization?

A

Metaphase (an egg MET a

sperm)

133
Q
Most oxygenated blood 
reaching the heart via IVC is 
diverted through the \_\_\_\_ \_\_\_\_
and pumped out the aorta to 
the head.
A

foramen ovale

134
Q

The right common cardinal
vein and right anterior
cardinal vein give rise to what
adult heart structure?

A

Superior vena cava

135
Q

The stapedius muscle of the
ear is formed by which
branchial arch?

A

2nd

136
Q
This type of bone formation 
consists of ossification of 
cartilaginous molds and 
forms long bones at primary 
and secondary centers.
A

Endochondral

137
Q

True or False, blood in the
umbilical vein is 100%
saturated with oxygen?

A

False, it is 80% saturated

138
Q

True or False, there are two

types of spermatogonia?

A

True, type A & type B

139
Q

What are the 1st branchial
arch derivatives innervated
by?

A

CN V2 and V3

140
Q

What are the 2nd branchial
arch derivatives innervated
by?

A

CN VII

141
Q

What are the 3rd branchial
arch derivatives innervated
by?

A

CN IX

142
Q

What are the 4th and 6th
branchial arch derivatives
innervated by?

A

CN X

143
Q

What are the cartilage
derivatives (5) of the 4th and
6th branchial arches?

A

— Thyroid - Cricoid -
Arytenoids - Corniculate -
Cuneiform

144
Q

What are the five 2’s
associated with meckel’s
diverticulum?

A
— 2 inches long - 2 feet from 
the ileocecal valve - 2% of the 
population - Commonly 
presents in the first 2 years of 
life - May have 2 types of 
epithelia
145
Q

What are the rule of 2’s for
the 2nd week of
development?

A
— 2 germ layers: epiblast 
& hypoblast - 2 cavities: 
amniotic cavity & yolk 
sac - 2 components to the 
placenta: cytotrophoblast 
& syncytiotrophoblast
146
Q

What are the rule of 3’s for

the 3rd week of development?

A

3 germ layers (gastrula):
ectoderm, mesoderm,
endoderm

147
Q

What can a persistent cervical

sinus lead to?

A

A branchial cyst in the neck

148
Q

What can be found in the

cortex of the thymus?

A

It is dense with immature T

cells

149
Q

What can be found in the

medulla of the thymus?

A

It is pale with mature T cells,
epithelial reticular cells, and
Hassall’s corpuscles

150
Q

What connects the thyroid

diverticulum to the tongue?

A

The thyroglossal duct

151
Q

What devlopmental
contributions does the 5th
branchial arch make?

A

None

152
Q
What do the 2nd - 4th 
branchial clefts form, which 
are obliterated by 
proliferation of the 2nd arch 
mesenchyme?
A

Temporary cervical sinuses

153
Q

What does aberrant
development of the 3rd and
4th pouches cause?

A

DiGeorge’s syndrome

154
Q

What does the 1st aortic arch

give rise to?

A

Part of the maxillary artery

155
Q

What does the 2nd
pharyngeal pouch develop
into?

A

Epithelial lining of the

palantine tonsils

156
Q

What does the 3rd aortic arch

give rise to?

A

Common carotid artery and
proximal part of the internal
carotid artery

157
Q

What does the 4th pharyngeal

pouch develop into?

A

Superior parathyroids

158
Q

What does the 5th aortic arch

give rise to?

A

Nothing

159
Q

What does the 5th pharyngeal

pouch develop into?

A

C cells of the thyroid

160
Q

What does the 6th aortic arch

give rise to?

A

The proximal part of the
pulmonary arteries and (on
left only) ductus arteriosus

161
Q

What does the ductus

arteriosus give rise to?

A

Ligamentum arteriosum

162
Q

What does the ductus
venosus shunt blood away
from?

A

Liver

163
Q

What does the fi rst branchial

cleft develop into?

A

The external auditory meatus

164
Q

What does the foramen ovale

give rise to?

A

Fossa ovalis

165
Q

What does the left 4th aortic

arch give rise to?

A

Aortic arch

166
Q

What does the ligamentum

venosum come from?

A

Ductus venosus

167
Q

What does the notochord give

rise to?

A

Nucleus Pulposus

168
Q

What does the primitive atria

give rise to?

A

Trabeculated left and right

atrium

169
Q

What does the primitive

ventricle give rise to?

A

Trabeculated parts of the left

and right ventricle

170
Q

What does the right 4th aortic

arch give rise to?

A

Proximal part of the right

subclavian artery

171
Q

Fighting~!

A

Hug hug~

172
Q

What does the right horn of
the sinus venosus give rise
to?

A

Smooth part of the right

atrium

173
Q

What does the spleen arise

from?

A

Dorsal mesentery, but is
supplied by the artery of the
foregut

174
Q

What does the thymus arise

from?

A

Epithelium of the 3rd

branchial pouch

175
Q

What does the thyroid

diverticulum arise from?

A

The fl oor of the primitive

pharynx

176
Q

What does the truncus

arteriosus give rise to?

A

The ascending aorta and

pulmonary trunk

177
Q

What does the umbilical

arteries give rise to?

A

Medial umbilical ligaments

178
Q

What ear muscle does the 1st

branchial arch form?

A

Tensor tympani

179
Q

What effect does 13-cis-
retinoic acid have on the
fetus?

A

Extremely high risk for birth

defects

180
Q

What effect does ACE

inhibitors have on the fetus?

A

Renal Damage

181
Q

What effect does iodide have

on the fetus?

A

Congenital goiter or

hypothyroidism

182
Q

What effect does warfarin and

x-rays have on the fetus?

A

Multiple anomalies

183
Q

What effects does cocaine

have on the fetus?

A

Abnormal fetal development

and fetal addiction

184
Q

What embryonic structure are
the smooth parts of the left
and right ventricle derived
from?

A

Bulbus cordis

185
Q

What embryonic structure
does the coronary sinus come
from?

A

Left horn of the sinus

venosus

186
Q

What embryonic structure
does the median umbilical
ligament come from?

A

Allantois (urachus)

187
Q

What fetal landmark has
developed within week 2 of
fertilization?

A

Bilaminar disk

188
Q

What fetal landmark has
occurred within week 1 of
fertilization?

A

Implantation

189
Q

What fetal landmark has
occurred within week 3 of
fertilization?

A

Gastrulation

190
Q

What fetal landmarks (2) have
developed within week 3 of
fertilization?

A

Primitive streak and neural

plate begin to form

191
Q

What five things arise from

neuroectoderm?

A

— Neurohypophysis - CNS
neurons - Oligodendrocytes -
Astrocytes - Pineal gland

192
Q

What four structures make up

the diaphragm?

A

— Septum transversum -
pleuroperitoneal folds - body
wall - dorsal mesentery of
esophagus

193
Q

What four things arise from

surface ectoderm?

A

— Adenohypophysis - Lens of
eye - Epithelial linings -
Epidermis

194
Q

What four things does
Meckel’s cartilage (from the
1st arch) develop into?

A

— Mandible - Malleus - Incus

- Sphenomandibular ligament

195
Q

What four things does
Reichert’s cartilage (from the
2nd arch) develop into?

A

— Stapes - Styloid process -
Lesser horn of hyoid -
Stylohyoid ligament

196
Q

What four things does the
dorsal pancreatic bud
become?

A

Body, tail, isthmus, and

accessory pancreatic duct

197
Q

What four things does the
mesonephric (wol”an) duct
develop into?

A

— Seminal vesicles -
Epididymis - Ejaculatory duct
- Ductus deferens

198
Q

What induces the ectoderm to
form the neuroectoderm
(neural plate)?

A

Notochord

199
Q

What is a hiatal hernia?

A

Abdominal contents herniate
into the thorax due to
incomplete development of
the diaphragm

200
Q

What is a hypospadias?

A

Abnormal opening of penile
urethra on inferior side of
penis due to failure of
urethral folds to close