Anatomy - sidebyside Flashcards
Define anisocytosis.
varying cell sizes
Defi ne poikilocytosis
varying cell shapes
From which cells do B cells
arise?
stem cells in bone marrow
From which cells do plasma
cells differentiate?
B cells
How can a Nissl stain be used
to differentiate microglia
from oligodendroglia?
Microglia are not discernable in a Nissl stain while oligodendroglia appear as small dark nuclei with dark chromatin
In what type of CNS tissue
(white or grey) are
oligodendroglia predominant?
white matter
Into what cell type does a
monocyte differentiate in
tissues?
Macrophages
Name 2 substances produced
by an eosinophil.
histiminase and arylsulfatase
Name the three types of
leukocytic granulocytes.
basophils, eosinophils, and
neutrophils
Name the two types of
mononuclear leukocytes.
lymphocytes and monocytes
What are 2 functions of T cell
lymphocytes?
- cellular immune response -
regulation of B lymphocytes
and macrophages
What are 2 morphological
features of microglia?
- small irregular nuclei - and
relatively little cytoplasm
What are 3 examples of
peripheral lymphoid tissue?
- follicles of lymph nodes -
white pulp of spleen -
unencapsulated lymphoid
tissue
What are 3 functions of a
macrophage?
- pagocytosis of bacteria, cell debris, and senescent red cells - scavenges damaged cells and tissues - can function as an antigen presenting cell
What are 3 morphological
characteristics of monocytes?
- Large - Kidney-shaped
nucleus - Extensive ‘frosted
glass’ cytoplasm
What are 4 characteristics of
the plasma cell morphology?
- Off center nucleus - Clock
face chromatin distribution -
Abundant RER - Well
developed Golgi apparatus
What are 4 morphologic
characteristics of
lymphocytes?
- Round - Small - Densely
staining nucleus - Small
amount of pale cytoplasm
What are 4 substances
contained within the
lysosomes of neutrophils?
- hydrolytic enzymes -
lysozyme - myeloperoxidase - lactoferrin
What are 4 types of cells into
which T cells di! erentiate?
- cytotoxic T cells (MHC I, CD8) - helper T cells (MHCII, CD4) - suppressor T cells - delayed hypersensitivity T cells
What are the 5 important
causes for eosinophilia in
humans?
Neoplastic, Asthma, Allergic
process, Collagen vascular
disease, and Parasites
(pneumonic NAACP)
What are the blood cell di !enentiation names of the ACTIVE T CELL line beginning with the pluripotent hematopoietic stem cell? (4)
- Pluripotent hematopoietic
stem cell - Lymphoblast - T
cell - Active T cell
What are the blood cell di !erentiation names of the ERYTHROCYTE cell line beginning with pluripotent hematopoietic stem cell? (4)
- Pluripotent hematopoietic
stem cell - Proerythroblast -
Reticulocyte - Erythrocyte
What are the blood cell di !erentiation names of the MONOCYTE cell lines beginning with the pluripotent hematopoietic stem cell? (3)
- Pluripotent hematopoietic
stem cell - Mono blast -
Monocyte
What are the blood cell di !erentiation names of the NEUTROPHIL, EOSINOPHIL, and BASOPHIL cell lines beginning with the myeloblast stage? (6)
- Myeloblast - Promyelocyte
- Myelocyte - Metamyelocyte
- Stab cell - Neutrophil,
eosinophil or basophil
What are the blood cell di !erentiation names of the PLASMA CELL line beginning with the pluripotent hematopoietic stem cell? (4)
- Pluripotent hematopoietic
stem cell - Lymphoblast - B
cell - Plasma cell
What are the blood cell di !erentiation names of the PLATELET CELL line beginning with the hematopoietic stem cell? (4)
- Pluripotento hematopoietic
stem cell - Megakaryoblast -
Megakaryocyte - Platelets
What are the components of
the air-blood barrier?
- Type I pneumocyte - tight
junction - endothelial cell
What are the steps of
maturation of a B cell? (2
points)
- maturation in the marrow -
migration to peripheral
lymphoid tissue
What are the substances
contained within the densly
basophilic granules of the
basophil? (4)
- Heparin (anticoagulant) - histamine (vasodilator) - vasoactive amines - Slow reacting substance of anaphylaxis
What are two basic
morphological characteristics
of neutrophils?
- multilobed nucleus - large,
spherical azurophilic primary
granules (lysosomes)
What are two important
functions of a neutrophil?
- acute infl ammmatory
response of a cell -
phagocytosis
What are two names for an
increased number of red
cells?
Erythrocytosis and
polycythemia
What cell type closely
resembles a mast cell?
basophil
What cranial nerves are
commonly involved in an
acoustic neuroma?
CN VII, VIII (association with
internal acoustic meatus)
What disease is characterized
by destruction of
oligodendroglia?
Multiple sclerosis
What does CD stand for?
cluster of di ! Erentiation
What drug prevents mast cell
degranulation?
What drug prevents mast cell
degranulation?
What immunoglobulin can
bind to the membrane of a
mast cell?
IgE
What is a reticulocyte?
What is a reticulocyte?
What is an important example
of a Schwannoma?
Acoustic neuroma
What is another name for
pulmonary sufractant?
DPPC
dipalmitoylphosphatidylcholine
What is percentage of
leukocytes in the blood exist
as basophils?
less than 1%
What is the ‘gap’ between the
myelination segment of 2
Schwann cells called?
Node of Ranvier
What is the advantage of the
large surface area:volume
ratio in erythrocytes?
easy gas exchange (Oxygen
and Carbon dioxide)
What is the basic morphologic
structure of an erythrocyte?
Anucleate, biconcave
What is the basic morphology
of an eosinophil? (2 things)
- bilobate nucleus - packed
with large eosinophilic
granules of uniform size
What is the embryologic
origin of microglia?
mesoderm
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kiss my dear bear~
What is the function of
Interferon gamma with
relation to macrophages?
macrophage activation
What is the function of
microglia?
phagocytosis in CNS
What is the function of
oligodendroglia?
myelination of multiple CNS
axons
What is the function of
pulmonary surfactant?
lowers alveolar surface
tension and prevents
atelectasis
What is the function of
Schwann cells?
myelination of PNS (a
Schwann cell myelinates only
one PNS axon)
What is the importance of the
lecithin:sphingomyelin ratio?
> 2.0 in fetal lung is
indicative of fetal lung
maturity
What is the importance of the
physiologic chloride shift in
erythrocytes?
Membranes contain the chloride bicarbonate antiport allowing the RBC to transport carbon dioxide from the the lung periphery for elimination.
What is the last segment of
lung tissue in which ciliated
cells are found?
respiratory bronchioles
What is the last segment of
lung tissue in which goblet
cells are found?
terminal broncioles (remember ciliated cells sweep away mucous produced by goblet cells and therefore run deeper)
What is the primary function
of a basophil?
Mediates allergic reactions
What is the primary function
of a leukocyte?
Defense against infections
What is the primary function
of a mast cell?
Mediates allergic reactions
What is the primary function
of a plasma cell?
production of large amounts
of a specific antibody to a
particular antigen
What is the primary source of
energy for erythrocytes?
glucose (90% anaerobically
degraded to lactate, 10% by
HMP shunt)
What is the process of
degranulation in mast cells?
release of histamine, heparin,
and eosinophil chemotactic
factors
What is the range of
concentration for leukocytes
in the blood?
4,000 - 10,000 cells per
microliter
What is the response of an
eosiniphil to antigen antibody
complexes?
high degree of phagocytosis
What is the response of
microglia to tissue dammage?
transformation into large
ameboid phagocytic cells
What is the response to
microglia infected with HIV?
fusion to form multinucleated
giant cells in CNS
What is the survival time for
an erythrocyte?
120 days
What pathognomonic change
is seen in neutrophils of a
person who is folate/vitamin
B12 defi cient?
hypersegmented polys
hypersegmented polys
1 - 6%
What percentage of
leukocytes exist as
neutrophils in the blood?
40 - 75%
What percentage of
leukocytes in blood are
monocytes?
2 - 10%
What process occurs when
type I pneumocytes are
damaged?
Type II pneumocytes develop
into type I
What substance in eosinophilic granules is primarily responsible for defense against helminths and protozoan infections?
major basic protein
Where is the site of
maturation of T lymphocytes?
Thymus
Which cell type constituitively
secretes pulmonary
surfactant?
Type II pneumocyte
Which cell type lines the
alveoli?
Type I pneumocyte
Which leukemia is the result
of plasma cell neoplasm?
Multiple myeloma
Which type of hypersensitivity
reaction is a mast cell
involved in?
Type I hypersensitivity
reaction
Which type of immunity do B
cells exhibit?
humoral immunity