Anatomy & Pathology Basics - Week 2 Flashcards
Anatomy definition
Study of how the body is shaped and structured
-structures, level of organization, relationship among body parts
Physiology definition
Study of body functions
Structural organization of the body
Cell
Basic unit of life
Mitosis
Process of cell reproduction
Mitosis 4 phases
Prophase
Metaphase
Anaphase
Telophase
Tissue
Group of similar cells from same source that together carry out a specific function
Tissues 4 types
Epithelial (4 types based on shape)
Connective
Muscle (3 types)
Nervous
Organs
Structure composed of 2 or more types of tissue & may have 1 or more functions and b part of 1 or more systems
Body systems
Composed of several organs & their related structures that work together to perform specific functions
Organism
Made up of many body systems that work together to maintain homeostasis
Anatomical position
Standard frame of reference
Body standing w face forward, arms at sides, palms forward and toes forward
Planes
Coronal or frontal
Anterior/ventral & posterior/dorsal
(Front & back of body)
Midsagittal or median
(Separates body into equal right & left halves)
Medial & lateral
(Closer to midline & farther away from midline)
Midline
(Starts at head & goes down body btwn legs to ground)
Transverse or horizontal
(Horizontal upper and lower sections)
Superior/cephalad & inferior/caudad
(Upward, toward, downward, toward tail)
Directional terms
Unilateral & bilateral
(One side, two side)
Dextrad & sinistrad
(Right, left side)
Afferent & efferent
Carrying toward, carrying away)
Ipsilateral & contralateral
(Same side, opposite side)
Superficial & deep
(Toward surface, away surface of body)
Proximal & distal
(Near origin, far from origin)
Positional terms
Supine
Prone
Lateral
Body cavities
Dorsal (posterior)
Nervous organs, cranial cavity, spinal cavity
Body cavities
Ventral (anterior)
Thoracic & abdominopelvic cavities
-separated by diaphragm
Abdominopelvic Quadrants
Imaginary vertical & horizontal lines intersecting at naval
Right upper quadrant (RUQ)
Left upper quadrant (LUQ)
Right lower quadrant (RLQ)
Left lower quadrant (LLQ)
Nine abdominopelvic regions
Right hypochondriac region
(Liver, gallbladder, right kidney)
Epigastric region
(Kidney, pancreas, liver, stomach)
Left hypochondriac region
(Stomach, liver, left kidney, spleen)
Right lumbar region
(Sm int., lg int (ascending) liver, right kidney)
Umbilical region
(Sm int., lg int (transverse) pancreas, stomach)
Left lumbar region
(Sm int, lg int (descending) left kidney)
Right iliac region
(Appendix, sm and lg int (cecum and ascending))
Hypogastric region
(Sm int, lg int (sigmoid), bladder
Left iliac region
(Sm int, lg int (descending & sigmoid))
pH
Acid-base balance of a solution on 1-14 scale
Neutral pH balance
pH is 7
Base or alkaline pH #
pH over 7
Fewer hydrogen ions
Acidic pH #
pH under 7
More hydrogen ions
Acid base balance
Homeostasis
Homeostasis btwn 7.35 & 7.45
Maintained by ; urinary, respiratory systems and chemical buffers
Protective mechanism
1st-line defense
Skin
Enzymes in tears & saliva
Mucus
Cilia
Stomach acid
Good bacteria
Urine
Protective mechanism
2nd-line defense
Immune system
- white blood cells and lymphatic system
Predisposing factors
Aka risk factors for disease
Heredity or genetics
Age
Gender
Environmental factors
Lifestyle
Causes of disease
Change in homeostasis
Result of body’s response to perceived threat
Common causes of disease
Genetics
Infectious pathogens
Inflammatory processes
Immunity
Nutritional imbalance
Trauma and environmental agents
Neoplasms
Genetics
Chromosomal error during cell division cause what 3 syndrome
Chromosomal disorders include
Down syndrome - extra chromosome
Trisomy X syndrome - female has 3 x
Turner syndrome - female only has one x
Genetics
Inheritance of defective gene(s)
Monogenic
-dominant, recessive, x-linked
Infectious pathogens
Microorganisms that cause disease
Infectious pathogens enter body through ;
Direct contact, indirect contact & vectors
Infectious pathogens
Incubation period
Time btwn exposure and emergence of signs and symptoms
Infectious pathogens
Noncomminicable vs communicable
Contagious : East communicable
Contagious period : time during which disease can spread to another person
Inflammatory response
Body’s efficient way of protecting itself when tissues are injured
- due to bacteria, trauma, heat, toxins, etc
Inflammatory response
Chemicals cause a response ;
Erythema
Edema
Pain
Warmth
Loss of function
Inflammatory response
Auto inflammatory diseases
Immunity
Antigens
Toxins, bacteria, viruses, other foreign substances
Immunity
Antibodies
Protein substances produced by the body to destroy or weaken antigens
Immunity
Immune response malfunctions
Allergies, autoimmunity, immunodeficiency
Nutritional imbalance
Too much or too little of a nutrient
Cause ;
Vitamin/mineral deficiencies
Vitamin/mineral excesses
Obesity
Starvation
Trauma & Environmental Agents
Common traumatic injuries
Fractures
Lacerated and ruptured organs
Bleeding
Neck/spinal injuries
Head injuries
Trauma & Environmental Agents
Psychological trauma
Obvious
Trauma & Environmental Agents
Environmental extreme
Obvious
Trauma & Environmental Agents
Other traumatic injuries
Poisoning
Insect and animal bites
Burns
Electrical shock
Near drownings
Neoplasms
Cells grow too quickly and or don’t die
Benign vs malignant
Benign
Cells in tumor are normal
Malignant
Cells in tumor are abnormal and grow uncontrollably so they’re cancerous
Cancer classified by tissue of origin
Carcinoma (squamous cell carcinoma & adenocarcinoma)
Sarcoma
Myeloma
Leukemia
Lymphoma (Hodgkin lymphoma & non-Hodgkin lymphoma
Mixed types
Neoplasms
Primary vs secondary tumor
Primary located at site where tumor originated & started to grow
Secondary aka metastatic are ones that spread to other parts of body
Neoplasms
Diagnosis
Biopsy, blood tests, imaging tests
Neoplasms
Doctors
Oncologist
Pathologist
Grade
Degree of abnormality of malignant cells. Grades 1-4
1: well differentiated
2: moderately differentiated
3 & 4: not at all like normal tissue
Neoplasm
Stage
Extent, including size & spread
Factors; location, cell type, tumor size, lymph node involvement, spread to other body parts, grade
TNM staging system widely used