Anaphylaxis Flashcards
Anaphylaxis is Ig____-mediated reaction
IgE
Which cells are responsible for Anaphylaxis?
Mast Cells and Basophils
Children MC get anaphylaxis from what?
Foods -> nuts, fruit, milk, eggs, shellfish, fish
Adults MC get anaphylaxis from what?
Bees and wasps
MC causes of anaphylaxis overall?
- Foods -> nuts, fruit, milk ,eggs, shellfish, fish
- Bees and Wasps
- Meds -> ABX, NSAIDs, Aspirin
- Animal venoms, latex, proteins (teatnus antitoxin, blood transfusions)
Which vaccines have a higher risk of anaphylaxis?
- flu
- MMR
- Yellow Fever
- Tetanus
What are the immune-complex mediators?
- Whole blood
- Plasma
- Dialysis Membranes
- Immunoglobulins
- Gamma Globulin
What are the non-immunologic activators that may cause anaphylaxis?
Opiates
Radiopaque contrast dye
ACE-I
ABX: Vancomycin, Aminoglycosides
How does a Hx of Atopy affect anaphylaxis?
- incr risk of anaphylaxis?
- incr death when anaphylaxis occurs?
It does NOT increase risk of anaphylaxis, but it does increase risk of DEATH when anaphylaxis occurs
Anaphylactoid Rxns vs Anaphylactic Rxns
Anaphylactoid Rxns are clinical indistinguishiable from anaphylaxis, but does not involve IgE and does not require prior sensitization.
They occur via direct stimulation of mast cells or via immune complexes that activate compliment system
Anaphylactoid Rxns
Direct mass cell stim
Immune complexes -> Compliment
Triggers: Iodine contrast, NSAIDs, Aspirin, Opiods, Monoclonal Antibodies, Exercise
Anaphylaxis
IgE
Req prior sensitization
Triggers: food, bees, wasps, meds
Which Anaphylaxis triggers has the highest reported deaths per year?
B-lactam ABX
Anaphylaxis affects which organ systems?
Skin, Resp, Cardio, GI
Anaphylaxis increases vascular permeability and causes which SS?
- Urticaria
- Angioedena
- Larygneal Edema
- Nasal Congestion
- GI Cramping/Vomiting
Initially, do CHILDREN present with trouble breathing or flushing/itchiness?
Trouble breathing
Resp -> then skin
Initially, do ADULTS present with trouble breathing or flushing/itchiness?
Initially, adults get flushing/itchiness