Anaphylactic Flashcards
What immunoglobulin?
IgE
Most important clinical allergic reaction
Anaphylaxis
What causes an immediate, severe systemic hypersensitivity reaction?
Rapid IgE mediated immune release of potent mediators from tissue mast cells & peripheral blood basophils.
Anaphylactoid
Clinical events caused by mediator release from mast cells and basophils by non IgE mediated triggering events.
What is specific immune system?
Responses result from destruction of foreign material & antigens to protect from injury
Bodies ability to fight bacteria, infection, phagocytize toxins
Innate immunity
Acquired immunity
Work of antibodies or lymphocytes against non-innate invasion
We develop in response to be exposed
Which immunity do we develop in response to be exposed
Acquired immunity
Which immunity is build within system
Innate immunity
Humoral associated with
B lymphocytes
Cell mediated responses associated with
T lymphocytes
What is multitude of plasma proteins
Complement system
20 different plasma proteins
Part of nonspecific immune system
What belongs in nonspecific immune system
Complement system
Vaccination
Passive immunity
Antibodies &/or activated T cells administered to provide protection from an invasive agent
Temporary effect from hrs to weeks
Ex breast milk
Passive immunity
What 2 pathways can activate proteins in the complement system?
- Initiated by IgE or IgM binding to antigen
- Alternative path, by endotoxic or drug reaction
The principle proteins are
C1-C9, B & D
What is the major function of complement system
To recognize bacteria directly and indirectly
It’s turned off most of the time, regulated by series of inhibitors
Haptens
Low MW substances <8000 MW
MUST combine with a protein or macromolecule to elicit an immune response
Antigen
Immunogens
Molecule capable of stimulating an immune response when injected
Example of haptens
Drugs or their metabolites
Chemicals in dust
Animal dander
Poison ivy
Monocytes & macrophages
- Processing & presenting antigens to T- cell lymphocytes - cell mediated
- effect inflammatory, tumoricidal, microbicidal functions
- at sites of chronic inflammation
- phagocytize & digest invading organisms
- monocyte-macrophage-pacific organ (lung, LN, spleen)
Neutrophils
- 1st line of D
- most numerous
- contain subs that aid in microbial killing: enzyme, acids, hydrogen peroxide, superoxide
Eosinophils
- associated w/parasitic infections
- secrete histamine
- they r recruited by mast cells & basophils to sites of infections, tumors, & allergic reactions
