Analgesics Flashcards

1
Q

principles of pain therapy (pre-opioid crisis)

A

give scheduled, verify effectiveness
allow for dose titration
provide long acting analgesics around the clock or short-acting analgesics PRN for breakthrough pain (severe pain)
NOT 1-2 tabs without indicating when to use 2 vs 1

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2
Q

non-opioids

A
NSAIDs and acetaminophen
if 1 class fails, try another
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3
Q

opiates

A

codeine and morphine

natural agents from opium

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4
Q

adjuvants

A

anticonvulsants, TCAs, SSRIs and SNRIs

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5
Q

opioids

A

Tramadol, Fentanyl, Oxycodone, Methadone, etc

modifications of natural opiates (synthetics)

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6
Q

NSAID combo’s

A

dual MOAs work in synergy

efficacy > sum of individual components

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7
Q

Acetaminophen MOA

A

inhibits both COX isoenz’s
COX inhibition may be more pronounced in brain
inhibits hypothalamic heat-regulating center
thus explaining its antipyretic effect

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8
Q

Acetaminophen Toxicity

A

at high dose: hydroxylation –> rearrangement –> reactive radical formation –> reacts with proteins and nucleic acids in the liver
glutathione in liver usually neutralizes this
toxicity based on amount of ingestion/plasma [] and time from ingestion

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9
Q

acetaminophen adjustment for renal impairment

A

metabolites accumulate
CrCl 10-50: administer 16 hrs
CrCl < 10: administer q 8 hrs

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10
Q

acetaminophen and ADHD risk

A

114,744 kids between 99’-09’
long term acetaminophen in preg had 2-fold inc risk
use for < 8 days during preg had dec risk

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11
Q

opioid vs non-opioid for extremity pain

A

pain scores are relatively the same when combo’ing acetaminophen + ibuprofen compared to acetaminophen + opioid

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12
Q

opioid receptors

A

u (mu) - classical analgesic receptor

basis of mixed agonist-antagonist agents

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13
Q

endorphins

A

derived from small endogenous peptide hor’s

accounts for variability of response to pain

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14
Q

other opiate/opioid SE’s

A

anticipate and prophylax for dec GI peristalsis

tolerance doesn’t develop to these effects

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15
Q

Tramadol

A

now a controlled substance so less abuse potential, reclassified in 2014 (Class III)

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16
Q

codeine

A
metabolized by CYP2D6 to morphine
CYP2D6 inhibitors dec its effect  
10% of pop lacks this enz  
Tylenol with codeine is C-III
Guaifenesin with codeine is C-V
17
Q

morphine

A

parenteral - to -oral dose ration of 1:3

18
Q

hydromorphone

A

alcohol destroyed time-release mech –> overdose

no active opioid metabolites

19
Q

oxycodone

A

metabolized by CYP2D6 to oxymorphone (also active)

useful in pt’s with this enz def or on inhibitors ; also useful in non-responders to codeine and hydrocodone

20
Q

CYP2D6 inhibitor meds

A

antiemetic phenothiazines, haloperidol, fluoxetine, paroxetine

21
Q

Meperidine

A

lipophilic, more rapid onset, short duration (2-3 hrs)
metab to active metab noremeperidine (neurotoxic)
long-metabolite t1/2 life
useful in controlling post-anesthesia shivering

22
Q

methadone

A

unique pharm-racemix mix of I and d isomers
I isomer –> opioid activity
d isomer –> NMDA antagonist and NE/5-HT reuptake inhibitor

23
Q

duragesic cautions

A

not usually used in opiate naive pt’s
monitor RR for first 24 hrs
replace q 72 hrs (don’t just add additional patches, look for multiple patches when admitting out-pt’s!)

24
Q

CDC opioid prescribing guidelines

A

nonpharm therapy and non-opioid therapy are preferred for chronic pain
clinicians should prescribe IR opioids instead of ER
for acute pain, use the lowest effective dose of IR opioids for 3-7 days

25
Q

CDC opioids prescribing guidelines cont

A

rx lowest effective dose. reassess risks and benefits when doses inc to > 50 morphine MME/day and avoid incing to > 90 MME without careful justification
eval benefits and harms within 1-4 weeks and again every 3 mo or more freq

26
Q

CDC opioids prescribing guidelines cont again

A

incorporate strategies to mitigate risk: offering naloxone
monitor a pt’s controlled substance abuse
use UDS before starting opioid therapy and check at least annually
avoid rx opioids and bozo’s concurrently
offer or arrange evidence based tx for pt’s with opioid use dx

27
Q

injectable Acetaminophen (Afirmed)

A

1000 mg/100 mL (post op x 4 doses, $$$$)
adults/adolescents > 50 kg: 1000 mg q6h, max 4 g/d
adults/adolescents < 50 kg: 15 mg/kg q6h, or 12.5 mg/kg q4h; max 75 mg/kg/d