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Analgesics & Gout Rx > Analgesics > Flashcards

Analgesics Flashcards

1
Q

First -Generation NSAIDs (COX-1 and COX-2 inhibitors include which medications SELECT All THAT APPLY
1. Aspirin
2. Ibuprofen
3. Naproxen
4. Indomethacin
5. Diclofenac
6. Ketorolac
7. Meloxicam

A

All are First Generation

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2
Q

True or False -Cyclooxygenase (COX) inhibitors includes Acetaminophen (APAP)?

A

True

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3
Q

What are the three main therapeutic effects of this class of medications?

A

Suppress inflammation
Relieve pain
Reduce fever

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4
Q

What drug is given first in an acute MI and a stroke?

A

Aspirin

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5
Q

Think about the function of COX-1 & COX-2, Is COX found in all tissues?

A

Yes

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6
Q

Which COX functions for platelets: platelet aggregation?

A

COX-1

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7
Q

Which COX can protect against colorectal cancer?

A

COX-2

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8
Q

There is only one (1) second-generation NSAID also known as selective COX-2 inhibitor, can you name it?

A

Celecoxib

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9
Q

Does Acetaminophen have anti-inflammatory properties, Yes or No?

A

No

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10
Q

NSAID-induced ulcers responsible for ~100,000 hospitalizations
Why?

A

COX-1 can cause gastric ulceration

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11
Q

What is given for Aspirin toxicity overdose?

A

Activated charcoal & in some cases hemodialysis

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12
Q

What is the chemical name for aspirin?

A

Chemical name acetylsalicylic acid (ASA)

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13
Q

What are drug or medications interactions with ASA?

A

1) Heparin & Warfarin (increase the risk of bleeding 2) ETOH (increase the risk of bleeding 3) Ibuprofen DECREASES the antiplatelet effects of low-dose ASA used to prevent an MI) 4) Glucocorticoids increase the risk of gastric bleeding. *Angiotensin converting enzyme inhibitors
Angiotensin II receptor blockers

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14
Q

What are the routes of administration for aspirin?

A

Oral & suppository

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15
Q

What is the Lethal dose in adults of aspirin (ASA)

A

20-25 grams

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16
Q

What is the Lethal dose in children?

A

4 grams

17
Q

Select all that apply What are the signs & symptoms of ASA toxicity?
1. Non-specific at first
2. Respiratory alkalosis (hyperventilation)
3. Hyperthermia, sweating
4. Electrolyte imbalances
5. Coma
6. Fever
7. Nausea & vomiting

A

1-5= 5& 6 are s& s of Acetaminophen OD

18
Q

What is the treatment for ASA overdose?

A

Treatment:
Supportive care
External cooling
Sodium bicarbonate infusion

19
Q

What are Fenoprofen
Ibuprofen
Ketoprofen
Naproxen
Diclofenac
Etodolac
Ketorolac
Meloxicam
Piroxicam
classified as ?

A

Non-Aspirin First Generation NSAIDs

20
Q

Non-Aspiring First Generations NSAIDs should be ordered and taken for chronic use? True or False, Why?

A

Use at lowest dose for shortest period of time

21
Q

Which First-Generation NSAIDs can be administered IV?

A

Indomethacin & Ketorolac

22
Q

Ketorolac has a Maximum day dose-how many days?

A

5 days

23
Q

What are the contraindications for First-Generation NSAIDs ?

A

PUD
Bleeding disorders
Hypersensitivity
CAUTION: pregnancy

24
Q

What are the adverse effects of the one lonely Second-generation NSAIDs, Celecoxib?

A

Gastric ulcers
CV events
Renal impairment

25
Q

Acetaminophen actions are to slow the production of prostaglandin ( COX enzymes in the CNS? True or False

A

True

26
Q

Acetaminophen are given for two reasons, what are they?

A

Pain relief
Reduce fever

27
Q

What are the adverse effects?

A

Anaphylaxis (very rare)
Steven’s Johnson Syndrome (very rare)

28
Q

What are the routes of administration?

A

Oral
Rectal
IV

29
Q

What are signs & symptoms of bleeding?

A

Bruising, petechiae, hematuria

30
Q

What is the treatment for acetaminophen overdose?

A

N-acetylcysteine IV or PO

31
Q

True or False GI bleeding can occur because NSAIDs affect platelet function?

A

True

32
Q

Important nursing interventions to assess select all that apply
1. Assess the patient for previous allergy to NSAIDs
2. Assess the GI system, and ask about any history of GI bleed, or PUD
3. Advise the patient to take the medication with food or milk to prevent GI distress
4. Advise to take on an empty stomach
5. Advise the patient to tell the provider about any of the OTC medication or vitamins before taking an NSAID

A

1,2,3, & 5 (4 is not correct taking an NSAID can cause an ulceration

Analgesics & Gout Rx (1 decks)

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