Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CPJE > Analgesics > Flashcards

Analgesics Flashcards

1
Q

What are 3 boxed warnings for all NSAIDS?

A
  • GI risk (bleeding & ulceration)
  • CV risk (increased MI & stroke)
  • CI after CABG

All RX NSAIDs require MED GUIDES

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are 4 side effects of NSAIDs?

A
  1. Decreased renal clearance
  2. Increased BP
  3. Premature closure of DA in fetus (avoid in 3rd tri of pregnancy)
  4. Photosensitivity
  5. GI - dyspepsia, abd pain, nausea
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the brand name for ibuprofen?

4 brands

A
  1. Advil
  2. Caldolor
  3. Motrin IB
  4. NeoProfen (indicated for closure of PDA in premature infants)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the usual dose of ibuprofen?
The max dose in Rx & OTC?

A

200-400 mg Q4-6H
OTC: 1.2 g/day
Rx: 400-800 mg Q6-8H
3.2 g/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the peds dosing for ibuprofen?

A

5-10 mg/kg/dose Q6-8H
Max: 40 mg/kg/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the brand name for indomethacin?

A

Indocin, Tivorbex

Available as capsule, suspension, suppository, injection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the dosing for indomethacin?

A

IR: 25-50 mg BID-TID
CR: 75 mg daily - BID
Tivorbex: 20 mg TID or 40 mg BID-TID (micronized for faster dissolution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is an unusual SE in indomethacin?

A

High risk for CNS side effects (avoid in psych conditions)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are notable NSAIDs DI?

A
  • bleeding risk
  • ototoxicity (with ASA - tinnitus)
  • increase the levels of lithium & MTX
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the brand name for Naproxen?

A
  1. Aleve
  2. Naprelan
  3. Naprosyn
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the OTC dosing for naproxen?

A

200 mg Q8-12H
Max: 3 tabs in 24 hours (600 mg)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the brand name for ketorolac?

A
  1. Toradol
  2. Acular (opthalmic)
  3. Sprix (nasal spray)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Boxed warning for ketolorac?

5 boxed warnings

A
  1. PO use for short-term mod-severe acute pain only as continuation of IV or IM (max combo duration is 5 days in adults)
  2. Avoid in advanced renal disease or risk for renal impairment due to volume depetion
  3. avoid use in L&D
  4. avoid use with ASA or NSAIDs
  5. Dose adjustments needed in elderly 65 yrs + or <50 kg
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Max dose of ketorolac?

A

40 mg/day (PO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Piroxicam brand, dose, & special notes

A

Brand: Feldene
Dose: 10-20 mg daily
Notes: high risk for GI tox, SJS/TEN
Used when other nsaids fail
May need protective agent for gut (PPI, misoprostol)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Sulindac brand, dose, special notes?

A

Brand: Clinoril, Sulin
Dose: 150-200 mg BID
Notes: sometimes used in reduced renal fxn, pts on lithium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Misc NSAIDs?

A
  • meclofenamate (Meclomen)
  • mefenamic acid (Ponstel)
  • ketoprofen (Orudis, Oruvail)
  • fenoprofen (Nalfon)
  • flurbiprofen (Ansaid)
  • oxaprozin (Daypro)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the OA dose for celecoxib?

Highest COX-2 selectivity

A

100 mg BID or 200 mg daily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the RA dose for celecoxib?

A

100-200 mg BID

20
Q

What is Consensi and what is it used for?

A

celecoxib + amlodipine
OA pain & HTN

21
Q

Contraindication for celecoxib use?

A

Sulfonamide allergy

22
Q

What forms does diclofenac come in?

A
  1. Gel (Voltaren)
  2. Patch (Flector)
  3. Packet (Cambia)
  4. Topical solution (Pennsaid, Xrylix)
  5. Capsule (Zorvolex)
  6. Capsule (Zipsor)
  7. Tablet (Voltaren)
23
Q

What is Arthrotec and who should not use it?

A

Voltaren + misoprostol (gut protective)
Women who are of childbearing potential unless capable of complying with effective contraceptive measures

24
Q

Dosing Conversions

Morphine IV/IM to PO

A

10 to 30

25
Q

Dosing Conversion

Hydromorphone IV to PO

A

1.5 to 7.5

26
Q

Dosing Conversion

Oxycodone

A

No IV/IM
20 mg (PO)

27
Q

Dosing Conversion

Hydrocodone

A

No IV/IM
30 mg

28
Q

Dosing Conversion

Codeine IV to PO

A

130 to 200

29
Q

Dosing Conversion

Fentanyl

A

No PO
IV/IM: 0.1

30
Q

Dosing Conversion

Meperidine

A

75 to 300

31
Q

Dosing Conversion

Oxymorphone

A

1 to 10

32
Q

Which opioids should you take on an empty stomach?

A

Oxymorphone (Opana)

33
Q

Which 2 opioids are CI in children <12 and <18 following tonsillectomy/adenoidectomy?

A

Tramadol (CIV), codeine (CII, CIII,CV)

34
Q

Common SE of opioids?

A
  1. Constipation
  2. N/V
  3. somnolence
  4. Dizziness/lightheadedness
  5. Risk of respiratory depression
35
Q

Dosage strengths of Fentanyl Patch?

5 strengths

A

12, 25, 50, 75, 100 mcg/hr

36
Q

What forms of Fentanyl are available?

A
  1. Patch (Duragesic)
  2. Lollipop (Actiq) - only for BTP in cancer
  3. Nasal Spray (Lazanda)
  4. Buccal tabs (Fentora)
  5. SL spray (Subsys)
37
Q

Common SE of Fentanyl

A
  1. Hyperhidrosis (excessive sweating)
  2. Dry mouth
  3. asthenia
  4. Loss of appetite
  5. Application site redness/erythema (patch)
38
Q

Special notes for Actiq?

A
  1. Only for cancer BTP
  2. REMS program
39
Q

How much morphine should a patient be using before switching to fentanyl patch?

A

60 mg/day or more for at least 7 days

40
Q

Which opioids do we want to watch out for QT prolongation?

A
  1. Methadone
  2. Hysingla ER (hydrocodone) doses >160 mg/day
  3. Olieridine (Olinvyk) doses >27 mg/day
41
Q

Which opioids should you avoid with CYP3A4i?

A
  1. hydrocodone
  2. oxycodone
  3. methadone
  4. Fentanyl
42
Q

Which opioids can be opened and sprinkled on soft food?

A

Kadian (morphine)
Xtampza ER (oxycodone)

43
Q

Which 2 opioids do you want to avoid with MAOi or have at least 2 week washout?

A
  1. Meperidine
  2. Hydromorphone
44
Q

What are 2 important points with meperidine?

A
  1. Renally cleared - normeperidine can accumulate and cause CNS toxicity (seizures)
  2. Serotonergic
  3. Elderly at risk
45
Q

Which opioids should you watch out for with renal impairment?

A
  1. Morphine
  2. meperidine
  3. oxycodone
46
Q

Which oxycodone formulations are abuse deterrent?

A
  1. Oxaydo
  2. OxyContin
  3. Xtampza ER

CPJE (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions