ANALGESIA GUIDLINES Flashcards

1
Q

for mild pain administer

A

Administer paracetamol.

Consider administering ibuprofen.

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2
Q

when should methoxy be admisntered

A

Consider administering methoxyflurane if there will be a significant delay in an opiate being administered

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3
Q

when should tramadol and ibuprofen be administered

A

Consider administering ibuprofen and/or tramadol, particularly if an opiate is not going to be administered.

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4
Q

Paracetamol should be administered in addition to

A

ther medicines for severe pain, particularly if the transport time is long. This is not a priority but will reduce the need for subsequent analgesia and improve the quality of pain relief.

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5
Q

Ibuprofen is useful in the context of….

A

soft tissue pain, musculoskeletal pain and renal colic, particularly if an opiate is not going to be administered.

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6
Q

Paramedics, ICPs and CCPs may administer 1% lignocaine for

A

moderate to severe pain associated with isolated injuries to digits when transport time is less than 60 minutes

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7
Q

Fentanyl over morphine is usually the preferred opiate if:

A

The patient requires analgesia for a short period of time only, or
The patient has renal impairment, or
The patient has signs of shock.

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8
Q

Morphine is usually the preferred opiate if

A

The patient requires analgesia for a longer period of time, or
The patient is receiving palliative care.

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9
Q

ibuprofen mechanism

A

Inhibits activity of prostaglandin synthetase, reducing prostaglandin production which reduces inflammation, pain and fever

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10
Q

ibuprofen contraindications

A

Known severe allergy
Pregnancy
Presence of sepsis, dehydration, shock or clinically significant bleeding (Ibuprofen can worsen renal impairment and increase bleeding risk)
Known worsening of bronchospasm with NSAIDS

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11
Q

cautions of ibuprofen

A

Taken within last four hours (Additional ibuprofen may be administered if the total dose in the last 4 hours does not exceed the CPG dose)

Abdo pain, particularly if unwell or vomiting (The possibility of significant intra-abdominal pathology exists and oral meds should usually be withheld)

Age greater than 75 years particularly if frail (Renal impairment is likely and ibuprofen worsens this)

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12
Q

ibuprofen dosage

A

→ 600 mg over 80 kgs
→ 400 mgs over 80 kgs

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13
Q

ibuprofen side affects

A

Renal impairment
Increased bleeding
Long term indigestion, GI ulceration and bleeding

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14
Q

ibuprofen onset

A

30-60 mins

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15
Q

ibuprofen duration

A

4-6 hours

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16
Q

paracetamol mechanism

A

→ Inhibits production of prostaglandins reducing pain and fever

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17
Q

paracetamol indications

A

Mild to moderate pain
Moderate to severe pain, in combination to other meds

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18
Q

paracetamol contraindications

A

nil

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19
Q

paracetamol cautions

A

Patient taken paracetamol within last 4 hours

Abdo pain, particularly if pt is unwell or vomiting. (The possibility of significant intra-abdominal pathology exists and oral medicines should usually be withheld)

Known severe liver disease (Liver disease must be severely impaired before paracetamol clearance is altered, but usually withhold)

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20
Q

paracetamol dosage

A

→1.5 g PO weighing greater than 80 kgs
→ 1 g PO weighing less than 80 kgs

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21
Q

paracetamol adverse affects

A

nil

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22
Q

paracetamol duration

A

4-6 h

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23
Q

brofen dose for a 10kg 1 year old

A

100 mg (5ml)

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24
Q

paracetamol dosage for a 10kg 1 year old

A

150 mg, 3 ml (50 mg/ml)

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25
Q

Fentanyl mechanism

A

Fentanyl is an opiate analgesic. It is an opiate agonist (or stimulator) that binds to opiate receptors in the brain and spinal cord causing analgesia.

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26
Q

indications of fentanyl

A

Moderate to severe pain.
Cardiogenic pulmonary oedema with severe anxiety.
Rapid sequence intubation.
Sedation post intubation.
Control of pain, agitation, or shortness of breath during end of life care.

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27
Q

fentanyl contraindications

A

allergy

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28
Q

fentanyl cautions

A

Altered level of consciousness. Fentanyl may further reduce the level of consciousness.

Aged less than one year. Children under the age of one year are at increased risk of respiratory depression following opiate administration.

Respiratory depression or at high risk of respiratory depression. For example, severe COPD, morbid obesity or on home BiPAP. Such patients may develop respiratory depression following opiate administration.

Labour. Opiates cross the placenta and may cause drowsiness and/or respiratory depression in the baby, particularly when administered within an hour or two of birth. Discuss administration with the lead maternity carer if possible. Following birth, close observation of the baby is required and personnel must be prepared to treat respiratory depression.
Concurrent administration of other opiates, ketamine or midazolam. This will increase and prolong the effects.

Aged greater than or equal to 75 years, particularly if frail. The effects of fentanyl will be increased and prolonged in this cohort.

Signs of shock. Fentanyl may make shock worse.

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29
Q

fentanyl and pregnancy

A

Safety has not been demonstrated in pregnancy, but fentanyl should be administered if indicated.

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30
Q

IV fentanyl adult dosage

A

IV for analgesia:
10-50 mcg every five minutes for an adult, as required. Use a dose at the lower end of the range if the patient is frail or has signs of shock.

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31
Q

paediatric fentanyl how to draw up

A

Fentanyl IV 10 mcg/ml (weight rounded up to 30 kg or more)

Draw up 2 ml of fentanyl from a 100 mcg/2 ml ampoule.
Dilute to a total volume of 10 ml using 0.9% sodium chloride.
Administer the volume from the tables as an IV bolus.

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32
Q

IV fentanyl dosage for 10kg 1 year old

A

Fentanyl IV (analgesia) 2-10 mcg 2-10 ml (1 mcg/ml)

33
Q

IN fentanyl dosage for 10kg 1 year old

A

Fentanyl IN (first dose) 20 mcg 0.4 ml (undiluted) -
Fentanyl IN (subsequent doses) 10 mcg 0.2 ml (undiluted)

34
Q

IM or SC dosage of fentanyl

A

IM and SC for analgesia if IV access cannot be obtained:
Adult:
50-100 mcg IM/SC.
Subsequent doses may be administered every 20 minutes up to a total of three doses.
Halve all doses if the patient is frail or has signs of shock.

35
Q

IN went how to draw up

A

Draw up fentanyl undiluted, placing half of the total dose into two separate 1 ml syringes. When drawing up the first syringe, draw up an additional 0.1 ml of fentanyl over and the above the planned volume and expel this slowly through the mucosal atomiser in order to fill the dead space. This does not need to be done with subsequent doses.
Administer fentanyl IN by rapidly injecting one syringe (half of the total dose) into each nostril. Rapid injection is required to achieve a fine mist, which maximises absorption.

36
Q

common adverse affects of fentanyl

A

Respiratory depression.
Bradycardia.
Hypotension.
Sedation.
Nausea and vomiting.
Itch.
Euphoria.

37
Q

fentanyl IV onset time

A

IV: 2-5 minutes. The maximal analgesic and respiratory depressant effects may not occur until 10-15 minutes and this may be longer in the elderly.

38
Q

IN fentanyl onset

A

IN: 5-10 minutes.

39
Q

SC/IM onset time

A

IM/SC: 5-10 minutes.

40
Q

duration of fentanyl

A

30-60 mins, The effect on respiration may last for several hours.

41
Q

usual prep of fentanyl

A

Ampoule containing 100 mcg in 2 ml

42
Q

why dose fentanyl drop blood pressure

A

Fentanyl may cause a small amount of histamine release. In combination with relief of pain this usually results in a small fall in blood pressure.

43
Q

common interactions with fentanyl

A

The effects will be increased in the presence of other opiates and sedatives, for example, benzodiazepines or alcohol.

44
Q

tramadol mechanism

A

Multiple actions in central nervous system, including opiate receptor stimulation and inhibition of the reuptake of noradrenaline and serotonin

45
Q

indications of tramadol

A

Moderate to severe pain, particularly if an opiate / ketamine is not going to be administered

46
Q

contraindications of tramadol

A

Known severe allergy
Age less than 12

47
Q

cautions of tramadol

A

Taken within last 4 hours (Additional can be given if it is clear the total dose within the last 4 hours does not exceed the dose in CPGs)

Abdo pain, particularly if unwell or vomiting (Possibility of significant intra-abdominal pathology exists and oral meds should usually be withheld)

Age greater than 75, particularly if previous history of dementia or confusion (Tramadol has anticholinergic activity and may worsen confusion)

Confusion (Tramadol has anticholinergic activity and may worsen confusion)

Pregnancy

48
Q

adverse affects of tramadol

A

Nausea or vomiting
Light headed or unusual
Sedation
Dry mouth

49
Q

onset and duration of tramadol

A

Onset
3-60 mins

Duration
4-8 hours

50
Q

morphine mechanism of action

A

Morphine is an opiate analgesic. It is an opiate agonist that binds to opiate receptors in the brain and spinal cord causing analgesia.

51
Q

indications of morphine

A

Moderate to severe pain.

Cardiogenic pulmonary oedema with severe anxiety.

Control of pain, agitation, or shortness of breath during end of life care.

52
Q

contraindications of morphine

A

allergies

53
Q

cautions of morphine

A

Altered level of consciousness. Morphine may further reduce the level of consciousness.

Aged less than one year. Children under the age of one year are at increased risk of respiratory depression following opiate administration.

Respiratory depression or at high risk of respiratory depression. For example, severe COPD, morbid obesity or on home BiPAP. Such patients may develop respiratory depression following opiate administration.

Labour. Opiates cross the placenta and may cause drowsiness and/or respiratory depression in the baby, particularly when administered within an hour or two of birth. Discuss administration with the lead maternity carer if possible. Following birth, close observation of the baby is required and personnel must be prepared to treat respiratory depression.
Concurrent administration of other opiates, ketamine or midazolam. This will increase and prolong the effects.

Aged greater than or equal to 75 years, particularly if frail. The effects of morphine will be increased and prolonged in this cohort.

Signs of shock. Morphine may worsen shock.

Known renal impairment.

54
Q

IV morphine dosage

A

1-5 mg every five minutes for an adult as required. Use a dose at the lower end of the range if the patient is frail or has signs of shock.
Consider commencing an infusion using service guidelines.

55
Q

IM/SC dosage of morphine

A

Adult:
5-10 mg IM/SC.
Subsequent doses may be administered every 20 minutes up to a total of three doses.

56
Q

how to draw up morphine

A

Dilute 10 mg of morphine to a total of 10 ml using 0.9% sodium chloride. This solution contains 1 mg/ml.
Administer IV as a bolus.

57
Q

common adverse affects of morphine

A

Respiratory depression.
Hypotension.
Sedation.
Nausea and vomiting.
Histamine release and itch.

58
Q

onset of morphine

A

IV: 2-5 minutes. The maximal analgesic and respiratory depressant effects may not occur until 10-15 minutes and this may be longer in the elderly.
IM/SC: 5-10 minutes.

59
Q

effects of morphine

A

30-60 minutes.
The effect on respiration may last for several hours, particularly in the elderly.

60
Q

ketamine mechanism

A

Ketamine has complex actions but is predominantly an N-methyl-d-aspartate (NMDA) receptor antagonist (blocker), resulting in inhibition of excitatory neurotransmitters in the brain.

Low doses cause analgesia, larger doses cause amnesia and dissociation, and high doses cause anaesthesia.

61
Q

ketamine indications

A

Severe pain that has not been adequately controlled with an opiate.

Inducing dissociation.

Acute behavioural disturbance causing a severe to immediately life-threatening risk to safety.

Rapid sequence intubation (RSI).

Significant movement during CPR that is interfering with resuscitation.

Asthma with severe agitation that is impairing the ability to safely provide treatment or transport.

62
Q

ketamine contraindications

A

Known severe allergy.
Aged less than one year.

63
Q

ketamine cautions

A

Altered level of consciousness. Ketamine may reduce the level of consciousness.

Signs of shock. Ketamine may make shock worse.
Current myocardial ischaemia. Ketamine may increase myocardial oxygen demand.

Concurrent administration of opiates or midazolam. This will increase and prolong the effects.

Aged greater than or equal to 75 years, particularly if frail. The effects of ketamine will be increased and prolonged in this cohort.

64
Q

IV ketamine for analgesia dosage

A

0.25 mg/kg IV up to a maximum of 25 mg for an adult, administered over approximately 15 minutes. Repeat as required.
Consider commencing an infusion using service guidelines.
See the paediatric drug dose tables for a child and administer IV over approximately 15 minutes. Repeat as required.

65
Q

IM ketamine analgesia dosage

A

IM or PO:
0.5 mg/kg IM or PO for an adult, up to a maximum of 50 mg, if IV access cannot be obtained. This may be repeated once after 20 minutes.
See the paediatric drug dose tables for a child. This may be repeated once after 20 minutes.

66
Q

how to draw up ketamine for analgesia

A

For analgesia: Dilute 100 mg (1 ml) of ketamine in a 100 ml bag of 5% glucose. Shake well and label:
For adults: draw up the dose and administer 2 mg (2 ml) every 1-2 minutes.
For children: draw up the dose, dilute the volume further to a total of 20 ml using 0.9% sodium chloride and administer 2 ml every 1-2 minutes.

67
Q

common adverse affects of ketamine

A

Transient hypertension.
Tachycardia.
Apnoea.
Nausea and vomiting.
Sedation.
Hallucinations.

68
Q

onset of ketamine

A

IV: 1-2 minutes.
IM: 5-10 minutes.

69
Q

duration of ketamine

A

10-60 mins

70
Q

preparation of ketamine

A

Ampoule containing 200 mg in 2 ml.

71
Q

Prior to administering ketamine for pain……

A

sufficient opiates should be administered so that further doses are not providing additional analgesia. This will usually require 150-200 mcg of fentanyl or 15-20 mg of morphine for an adult.

72
Q

how to round when calculating doses for ketamine

A

Round the patient’s weight up to the nearest 10 kg when calculating doses.

73
Q

methoxy indications

A

Moderate to severe pain, especially when there is a delay in opiate admin

74
Q

contraindications of methoxy

A

Known severe allergy

Hx malignant hyperthermia (Inherited disorder of muscle metabolism, when exposed to anaesthetic agents the patient may develop a life-threatening hypermetabolic state with severe hyperthermia)

Renal impairment (Kidneys/ureter/urethra) (Dialysis pts, kidney stones and renal colic pts can have methoxy)

Administered in last week (Increase risk of renal impairment with frequent admin)

75
Q

cautions of methoxy

A

Age greater than 75, particularly if frail
Pre-eclampsia (Renal impairment is likely and methoxy will worsen this)
Confined space

76
Q

dosage of methoxy

A

→6 mls for patients aged above 12
→ 3 mls child aged less than 12

77
Q

adverse effects of methoxy

A

Sedation
Light headed

78
Q

onset and duration of methoxy

A

Onset
1-2 mins

Duration
2-5 mins