Analgesia Flashcards
what are the 6 main analgesics prescribed
- aspirin (NSAID)
- ibuprofen (NSAID)
- diclofenac (NSAID)
- paracetamol
- dihydrocodeine (opioid)
- carbamazepine
what causes pain
production of prostaglandins which sensitise the tissues to other inflammatory products e.g. leukotrienes which results in pain
how are prostaglandins formed
trauma/infection lead to breakdown of membrane phospholipids producing arachidonic acid which is then broken down to form prostaglandins
how to reduce pain
decrease prostaglandin production
describe the arachidonic acid pathway
tissue injury -> injury to phospholipid cell membrane causing release of arachidonic acid ->
1. cyclooxygenase pathway (COX-1/COX-2) -> prostaglandin (PGG2) -> prostaglandin H2 (PGH2) -> prostacyclin / prostaglandin (cause pain, inflammation), thromboxane (cause platelet aggregation)
OR
2. 5-lipooxygenase pathway -> leukotrienes (cause bronchoconstriction / asthma attacks / smooth muscle contraction)
main properties of aspirin
- analgesic
- antipyretic (prevent / reduce fever)
- anti inflammatory
- metabolic
aspirin mechanism of action
inhibits cyclooxygenases (COX 1&2) so reduced production of prostaglandins
more effect at inhibiting COX-1 which reduces platelet aggregation (predisposes to damage of gastric mucosa)
analgesic properties of aspirin
analgesic action exerted both peripherally & centrally
peripheral actions predominate
analgesic action results from inhibition of prostaglandin synthesis in inflamed tissues (COX inhibition)
antipyretic properties of aspirin
prevents temperature rising effects of interleukin-1 and rise in brain prostaglandin levels so reduces elevated temp in fever
NB - doesn’t reduce normal temp
anti inflammatory properties of aspirin
prostaglandins are vasodilators and as such affect capillary permeability
aspirin = good anti inflammatory and will reduce redness / swelling as well as pain at site of injury
adverse effects of prescribing aspirin (4)
- GIT problems
- hypersensitivity
- overdose - tinnitus, metabolic acidosis
- aspirin burns - mucosal
describe adverse aspirin effect on GIT
mostly on mucosal lining of stomach; prostaglandins PGE2 & PGI2 inhibit gastric acid secretion, increase blood glow through gastric mucosa & help production of mucin by cells in stomach lining (cytoprotective action)
care must be taken for patients with ulcers & GORD
describe adverse effect of hypersensitivity when prescribing aspirin
reactions include:
- acute bronchospasm / asthma type attacks
- skin rashes / urticaria / angioedma
- other allergies
caution when prescribing to asthmatics
adverse effect of overdose when prescribing aspirin
- hyperventilation
- tinnitus, deafness
- vasodilation & sweating
- metabolic acidosis (can be life threatening)
- coma
adverse effect of mucosal burns when prescribing aspirin
direct effect of salicylic acid as aspirin applied locally to oral mucosa results in chemical burns. it has no topical effect. ensure it is taken with water
name 13 groups you should avoid prescribing aspirin to
- peptic ulceration
- epigastric pain
- bleeding abnormalities
- anticoagulants
- pregnancy / breast feeding
- patients on steroids
- renal / hepatic impairment
- u16s
- asthmatics - ask if used before and if any problems
- hypersensitivity to other NSAIDs
- taking other NSAIDs
- elderly
- G6PD deficiency
why avoid prescribing aspirin to those on anticoagulants
it enhances warfarin & other coumarin anticoagulants; displaces warfarin from binding sites on plasma proteins and increases free warfarin.
majority of warfarin in bound i.e. inactive so if more is released this will become active thus increasing bleeding tendency
why avoid prescribing aspirin in pregnancy/lactation
esp in 3rd trimester as nearer delivery and may cause impairment of platelet function:
- increased risk of haemorrhage & jaundice in baby
- can prolong / delay labour
contraindicated in breastfeeding - reye’s syndrome
why avoid prescribing aspirin to those on steroids
approx 25% of patients on long term systemic steroids will develop a peptic ulcer & if they have undiagnosed ulcer, aspirin will result in perforation
why avoid prescribing aspirin in renal / hepatic impaired
aspirin metabolised in liver & excreted mainly in kidney
if renal impairment excretion may be reduced / delayed
not a complete contraindication but administer with care and avoid if severely impaired
relationship between prostaglandins and the kidney
prostaglandins PGE2 & PGI2 are powerful vasodilators synthesised in renal medulla and glomeruli respectively & are involved in control of renal blood flow and excretion of salt & water
inhibition of renal prostaglandin synthesis may result in
sodium retention
reduced renal blood flow
renal failure
NSAIDs may cause interstitial nephritis & hyperkalaemia
why avoid prescribing aspirin in u16s
reye’s syndrome - up to 50% mortality due to encephalopathy so contraindicated in u16s, avoid during fever or viral infection
fatty degenerative process in liver that causes profound swelling in brain
why avoid prescribing aspirin to those with G6PD deficiency
glucose-6-phosphate dehydrogenase deficiency
susceptible to acute haemolytic anaemia and aspirin carries risk of haemolysis in some of these individuals