Anal Masses Flashcards
Premalignant Lesions (AIN)
Clinical
Pain
Bleeding
Mass +- ulceration
Pruritus
Premalignant Lesions (AIN)
Aetiology
HPV 16,18
Premalignant Lesions (AIN)
Risk Factors
• Host
-Immunocompromised: HIV
• Contamination
- Anal intercourse - Many sexual partners
Premalignant Lesions (AIN)
Diagnosis
• Biopsy
Acetic acid -> white lesions -> biopsy
Premalignant Lesions (AIN)
Histology
• SCC
- LSIL - HSIL
Premalignant Lesions (AIN)
Prevention
Smear of anus yearly in immunocompromised patients
Anal Cancer
Clinical
Pain
Bleeding
Mass +- ulceration
Pruritus
Anal Cancer
Aetiology
HPV 16,18
Anal Cancer
Risk Factors
Host:
-Immunocompromised: HIV
Contamination:
- Anal intercourse - Many sexual partners
Anal Cancer
Diagnosis
• Biopsy
Acetic acid -> white lesions -> biopsy
Anal Cancer
Histology
Proximal (glandular epithelium): adenocarcinoma
Distal (skin): SCC; MM
Anal Cancer
Staging (TNM)
• T
- > 2cm
- 2-5cm
- > 5cm
- Local invasion
• N
- Perirectal
- Ipsilateral groin/pelvis (internal iliac)
- 1 +2 OR both sides of groin/pelvis (internal iliac)
• M
Mets
Anal Cancer
Stages
- Stage 1: confined T1
- Stage 2: confined T2,T3
- Stage 3: local invasion T4 and/or LNs (Any T, Any N)
- Stage 4: mets
Anal Cancer
Management
• Curative: T1,2,3,4
− < 1cm/doesn’t involve sphincter muscle: local resection
− All the others: Chemoradiation (nigro protol: 5-fluorouracil and mitomycin and medical radiation) if remains/recurrent: APR (abdominoperineal resection)
• Palliative: M1
Anal Cancer
Prevention
Smear of anus yearly in immunocompromised patients