Anaesthetics Overview Flashcards
What are the three stages of GA?
Induction
Maintenance
Emergence/reversal
What are the components of the anaesthetic triad?
Unconsciousness
Muscle relaxation
Analgesia
Which agent is most commonly used for induction of GA?
IV propofol
What is the onset and offset time for propofol?
Onset about 30 seconds
Offset 3-7 minutes
What are some of the physiological effects of propofol?
Hypnosis Myocardial depression Reduced SVR Respiratory depression Obtunds upper airway reflexes (good for putting in LMA)
Which allergy would be a contraindication for propofol?
Egg
Which factors might lead to a delay in induction of anaesthesia?
Slow arm to brain circulation time e.g. elderly, CVD
Patient anxiety
Recreational drug use
Extravasation (drug leaks out of vein)
Which other type of agent is used for induction?
Inhalation of volatile agent e.g. sevoflurane
In which situations is inhaled induction commonly used?
Paediatrics
Cases of difficult airway
Difficult IV access
Inhaled foreign body (maintaining spontaneous ventilation is preferable)
Why is rapid sequence induction (RSI) used?
To minimise risk of regurgitation + aspiration
Give some examples of when RSI might be used:
Bowel obstruction or intra-abdominal pathology
Un-fasted patient in an emergency or trauma situation
Obstetric emergency
Strong history of reflux
How does RSI work?
Pre-oxygenation with 100% O2
Cricoid pressure (compress oesophagus) –> prevents regurgitation of gastric contents
Pre-oxygenation plus rapid induction + paralysis removes the need for bag + mask ventilation before intubation
–> risk of gastric insufflation + regurgitation is reduced
What are the different types of muscle relaxants?
Depolarising –> e.g. suxamethonium
Non-depolarising –> e.g. atracurium, rocuronium
When is suxamethonium a good muscle relaxant to use?
RSI Difficult airway (as wears off quickly)
What are some side effects of suxamethonium?
Muscle pain (as causes fasciculations during the operation) Jaw rigidity Hyperkalaemia (can be toxic) Bradycardia Malignant hyperthermia