Anaesthetics: Essential Pain Management Flashcards

1
Q

What is pain?

A

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage

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2
Q

What are the physical benefits for the patient if we treat pain?

A
  • Improved sleep, better appetite
  • Fewer medical complications (e.g. heart attack, pneumonia)
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3
Q

What are the psychological benefits for the patient if we treat pain?

A
  • Reduced suffering
  • Less depression, anxiety
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4
Q

What are the benefits for the family if we treat pain?

A
  • Improved functioning as a family member (e.g. as a father or mother)
  • Able to keep working
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5
Q

What are the benefits for society if we treat pain?

A
  • Lower health costs (e.g. hospital stay)
  • Able to contribute to the community
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6
Q

How can pain be classified?

A
  • Duration
    • Acute
    • Chronic Cause
  • Cancer / Non-cancer
  • Mechanism
    • Nociceptive
    • Neuropathic
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7
Q

Describe nociceptive pain

A
  • Sharp +/- dull
  • Well localised
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8
Q

When does nociceptive pain occur?

A

When there is obvious tissue injury or illness

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9
Q

What is the function of nociceptive pain?

A

It has a protective function and is also referred to as inflammatory pain

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10
Q

When does neuropathic pain occur?

A

When there is nervous system damage or abnormality

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11
Q

Describe neuropathic pain

A
  • Burning, shooting +/- paraesthesia
  • Not well localised
  • Does not have a protective function
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12
Q

What are the 4 steps in the physiology of pain?

A
  • Periphery
  • Spinal cord
  • Brain
  • Modulation
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13
Q

What physiology occurs in the periphery during the pain response?

A
  • Tissue injury
  • Release of chemicals e.g. prostaglandins, substance P
  • Stimulation of pain receptors (nociceptors)
  • Signal travels in Aδ or C nerve to spinal cord
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14
Q

What physiology occurs in the spinal cord during the pain response?

A
  • Dorsal horn is the first relay station
  • Aδ or C nerve synapses with second nerve
  • Second nerve travels up contralateral side of spinal cord
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15
Q

What physiology occurs in the brain during the pain response?

A
  • Thalamus is the second relay station
  • Connections to many parts of the brain including cortex, limbic system and brainstem
  • Pain perception occurs in the cortex
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16
Q

What physiology occurs during modulation in the pain response?

A
  • Descending pathway from brain to dorsal horn
  • Usually decreases pain signal
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17
Q

What is the gate theory?

A

Stimulation by non-noxious input is able to suppress pain by closing the ‘gate’ to painful input preventing pain sensation from travelling to the cortex

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18
Q

Give examples of neuropathic pain

A
  • Nerve trauma, diabetic pain (damage)
  • Fibromyalgia, chronic tension headache (dysfunction)
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19
Q

What is the pathology behind neuropathic pain?

A
  • Increased receptor numbers
  • Abnormal sensitisation of nerves (peripheral and central)
  • Chemical changes in the dorsal horn
  • Loss of normal inhibitory modulation
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20
Q

What non-drug treatments can be used to act at the periphery?

A
  • Rest
  • Ice
  • Compression
  • Elevation
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21
Q

What drugs can be used to act at the periphery?

A
  • NSAIDs
  • Local anaesthetics
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22
Q

What non-drug treatments can be used to act at the spinal cord?

A
  • Acupuncture
  • Massage
  • TENS
23
Q

What drugs can be used to act at the spinal cord?

A
  • Local anaesthetics
  • Opioids
  • Ketamine
24
Q

What non-drug treatment can be used to act at the brain?

A

Psychological therapies

25
What drugs can be used to act on the brain?
* Paracetamol * Opioids * Amitriptyline
26
What route of drug delivery is preferred?
Oral
27
What are the advantages of paracetamol?
* Cheap, safe * Can be given orally, rectally or intravenously
28
What is the disadvantage of paracetamol?
Liver damage in overdose
29
What is paracetamol good for?
Mild pain (by itself) or moderate to severe pain (with other drugs)
30
Give examples of NSAIDs
* Aspirin * Ibuprofen * Diclofenac
31
What are the advantages of NSAIDs?
* Cheap * Generally safe
32
What is the disadvantage of NSAIDs?
* GI and renal side effects * Can cause exacerbation of asthma
33
What are NSAIDs good for?
Nociceptive pain
34
What are the advantages of codeine?
* Cheap * Safe
35
What is codeine good for?
Mild to moderate acute nociceptive pain
36
What are the disadvantages of codeine?
* Can cause constipation, drowsiness * Not good for chronic pain - addictive
37
What are the advantages of morphine?
* Cheap, generally safe * Can be given IV, IM, SC * Effective if given regularly
38
What is morphine good for?
* Moderate to severe nociceptive pain (i.e. post-op pain) * Chronic cancer pain
39
What are the disadvantages of morphine?
* Constipation * Respiratory depression in high dose * Misunderstandings about addiction * Controlled drug
40
How does the oral dose of morphine differ from the IV/IM/SC dose?
Oral dose is 2-3 times that of IV/IM/SC dose
41
What is amitriptyline?
Tricyclic antidepressant
42
How does amitriptyline work?
Increases descending inhibitory signals
43
What are the advantages of amitriptyline?
* Cheap, safe in low dose * Good for neuropathic pain * Also treats depression and poor sleep
44
What are the disadvantages of amitriptyline?
Anti-cholinergic side effects (i.e. glaucoma, urinary retention)
45
Give examples of anticonvulsants that can be used for pain.
* Gabapentin (neurotonin) * Carbamazepine (tegretol) * Sodium valproate (epilim)
46
Why are anticonvulsants also known as membrane stabilisers?
They reduce abnormal firing of nerves
47
What type of pain are anticonvulsants good for?
Neuropathic pain
48
What are the steps in the WHO pain ladder?
* Step 1 -Paracetamol +/- NSAIDs * Step 2 Paracetamol (+/- NSAIDs) + Codeine/alternative * Step 3 Paracetamol (+/-NSAID) + Morphine
49
How should the pain ladder be used as pain resolves?
* Move from top to middle of WHO ladder * Continue bottom rung drugs at all times * Lastly stop NSAIDs, then paracetamol as more adverse side effects with NSAIDs
50
What is the RAT approach to pain?
* Recognise * Assess * Treat
51
How do you assess pain severity?
* Verbal scale (mild, mod, severe) * Numerical rating scale * Visual analogue scale * Faces scale
52
What other factors can influence the severity of a patient's pain?
Physical factors * Other illnesses Psychological and social factors * Anger, anxiety, depression * Lack of social support
53
What drugs are used in neuropathic pain?
* Amitriptyline (tricyclic antidepressant) * Gabapentin (anticonvulsant) * Duloxetine (selective serotonin noradrenaline reuptake inhibitor - SNRI)