Anaesthetics: Essential Pain Management Flashcards

1
Q

What is pain?

A

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage

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2
Q

What are the physical benefits for the patient if we treat pain?

A
  • Improved sleep, better appetite

- Fewer medical complications (e.g. heart attack, pneumonia)

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3
Q

What are the psychological benefits for the patient if we treat pain?

A
  • Reduced suffering

- Less depression, anxiety

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4
Q

What are the benefits for the family if we treat pain?

A
  • Improved functioning as a family member (e.g. as a father or mother)
  • Able to keep working
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5
Q

What are the benefits for society if we treat pain?

A
  • Lower health costs (e.g. hospital stay)

- Able to contribute to the community

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6
Q

How can pain be classified?

A

Duration

  • Acute
  • Chronic

Cause

  • Cancer
  • Non-cancer

Mechanism

  • Nociceptive
  • Neuropathic
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7
Q

What is acute pain?

A

Pain of recent onset and probable limited duration

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8
Q

What is chronic pain?

A
  • Pain lasting for more than 3 months
  • Pain lasting after normal healing
  • Often no identifiable normal healing
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9
Q

Describe pain from cancer?

A
  • Progressive

- May be a mixture of acute and chronic

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10
Q

Describe non-cancer pain

A
  • Can have many different causes

- Can be acute or chronic

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11
Q

Describe nociceptive pain

A
  • Sharp +/- dull

- Well localised

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12
Q

When does nociceptive pain occur?

A

When there is obvious tissue injury or illness

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13
Q

What does nociceptive pain function as?

A

It has a protective function and is also referred to as inflammatory pain

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14
Q

When does neuropathic pain occur?

A

When there is nervous system damage or abnormality

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15
Q

Describe neuropathic pain

A
  • Burning, shooting +/- numbness, pins and needles

- Not well localised

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16
Q

What are the 4 steps in the physiology of pain?

A
  • Periphery
  • Spinal cord
  • Brain
  • Modulation
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17
Q

What physiology occurs in the periphery during the pain response?

A
  • Tissue injury
  • Release of chemicals e.g. prostaglandins, substance P
  • Stimulation of pain receptors (nociceptors)
  • Signal travels in Aδ or C nerve to spinal cord
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18
Q

What physiology occurs in the spinal cord during the pain response?

A
  • Dorsal horn is the first relay station
  • Aδ or C nerve synapses (connects) with second nerve
  • Second nerve travels up opposite side of spinal cord
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19
Q

What physiology occurs in the brain during the pain response?

A

-Thalamus is the second relay station
Connections to many parts of the brain including cortex, limbic system and brainstem
-Pain perception occurs in the cortex

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20
Q

What physiology occurs during modulation in the pain response?

A
  • Descending pathway from brain to dorsal horn

- Usually decreases pain signal

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21
Q

What is the gate theory?

A

Stimulation by non-noxious input is able to suppress pain by closing the ‘gate’ to painful input preventing pain sensation from travelling to the cortex

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22
Q

Give examples of neuropathic pain

A
  • Nerve trauma, diabetic pain (damage)

- Fibromyalgia, chronic tension headache (dysfunction)

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23
Q

What is the pathology behind neuropathic pain?

A
  • Increased receptor numbers
  • Abnormal sensitisation of nerves (peripheral and central)
  • Chemical changes in the dorsal horn
  • Loss of normal inhibitory modulation
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24
Q

What types of drugs can be used for the treatment of pain?

A
  • Simple analgesics
  • Opioids
  • Other analgesics
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25
Give examples of simple analgesics.
- Paracetamol (acetaminophen) | - Non-steroidal anti-inflammatory drugs
26
Give examples of opioid drugs
Mild -Codeine, dihydrocodeine Strong -Morphine, oxycodone, fentanyl
27
Other than simple analgesics and opioids, what other drugs can be used for pain?
- Tramadol (mixed opiate and 5HT/NA reuptake inhibitor) - Antidepressants (e.g. amitriptyline, duloxetine) - Anticonvulsants (e.g. gabapentin) - Ketamine (NMDA receptor antagonist) - Local anaesthetics - Topical agents (e.g. Capsaicin)
28
What non-drug treatments can be used to act at the periphery?
- Rest - Ice - Compression - Elevation
29
What drugs can be used to act at the periphery?
- NSAIDs | - Local anaesthetics
30
What non-drug treatments can be used to act at the spinal cord?
- Acupuncture - Massage - TENS
31
What drugs can be used to act at the spinal cord?
- Local anaesthetics - Opioids - Ketamine
32
What non-drug treatment can be used to act at the brain?
Psychological therapies
33
What drugs can be used to act on the brain?
- Paracetamol - Opioids - Amitriptyline - Clonidine
34
What route of drug delivery is preferred?
Oral
35
What are the advantages of paracetamol?
- Cheap, safe | - Can be given orally, rectally or intravenously
36
What is the disadvantage of paracetamol?
Liver damage in overdose
37
What is paracetamol good for?
Mild pain (by itself) or moderate- severe pain (with other drugs)
38
Give examples of NSAIDs
- Aspirin - Ibuprofen - Diclofenac
39
What are the advantages of NSAIDs?
- Cheap | - Generally safe
40
What is the disadvantage of NSAIDs?
- GI and renal side effects | - Sensitive for asthmatics
41
What are NSAIDs good for?
Nociceptive pain
42
What are the advantages of codeine?
- Cheap | - Safe
43
What is codeine good for?
Mild to moderate acute nociceptive pain
44
What are the disadvantages of codeine?
- Can cause constipation | - Not good for chronic pain
45
What is tramadol?
Painkiller with a weak opioid effect plus inhibitor of serotonin and noradrenaline reuptake (modulation)
46
What are the advantages of tramadol?
- Less respiratory depression - Can be used with opioids and simple analgesics - Not a controlled drug
47
What are the disadvantages of tramadol?
Nausea and vomiting
48
What are the advantages of morphine?
- Cheap, generally safe - Can be given IV, IM, SC - Effective if given regularly
49
What is morphine good for?
- Moderate to severe nociceptive pain (i.e. post-op pain) | - Chronic cancer pain
50
What are the disadvantages of morphine?
- Constipation - Respiratory depression in high dose - Misunderstandings about addiction - Controlled drug
51
How does the oral dose of morphine differ from the IV/IM/SC dose?
Oral dose is 2-3 times that of IV/IM/SC dose
52
What is amitriptyline?
Tricyclic antidepressant
53
How does amitriptyline work?
Increases descending inhibitory signals
54
What are the advantages of amitriptyline?
- Cheap, safe in low dose - Good for neuropathic pain - Also treats depression and poor sleep
55
What are the disadvantages of amitriptyline?
Anti-cholinergic side effects (i.e. glaucoma, urinary retention)
56
Give examples of anticonvulsants that can be used for pain.
- Carbamazepine (tegretol) - Sodium valproate (epilim) - Gabapentin (neurotonin)
57
Why are anticonvulsants also known as membrane stabilisers?
They reduce abnormal firing of nerves
58
What are anticonvulsants good for?
Neuropathic pain
59
How should neuropathic pain be managed?
Use alternative analgesics and/or psychological and non-drug treatments
60
What are the steps in the WHO pain ladder?
Step 1 -Paracetamol +/- NSAIDs Step 2 Paracetamol (+/- NSAIDs) + Codeine/alternative Step 3 Paracetamol (+/-NSAID) + Morphine
61
How should the pain ladder be used for mild pain?
Start at bottom of the pain ladder
62
How should the pain ladder be used for moderate pain?
Bottom of pain ladder plus the middle rung
63
How should the pain ladder be used for sever pain?
- Bottom of pain ladder plus top of ladder. Miss out the middle - It is okay to start at the top of the ladder for sever/unbearable pain
64
How should the pain ladder be used as pain resolves?
- Move down the ladder, passing the middle rung first - Move from top to middle of WHO ladder - Continue bottom rung drugs at all times - Lastly stop NSAIDs, then paracetamol as more adverse side effects with NSAIDs
65
What is the RAT approach?
- Recognise - Assess - Treat
66
How do you recognise that a patient is in pain?
Does the patient have pain? - Ask - Look (frowning, moving easily, sweating?) Do other people know the patient has pain? - Other health workers - Patient's family
67
How do you assess a patient's pain?
Severity - Pain score at rest and on movement - How does the pain affect the patient? Type - Acute vs chronic - Cancer vs non-cancer - Nociceptive vs neuropathic
68
What neuropathic features may pain have?
- Burning or shooting pain - Phantom limb pain - Other features (pins and needles, numbness)
69
What other factors can influence the severity of a patient's pain?
Physical factors -Other illnesses Psychological and social factors - Anger, anxiety, depression - Lack of social support
70
What drugs are used in neuropathic pain?
- Amitriptyline - Gabapentin - Duloxetine
71
What should be done after using the RAT algorithm?
Reassess the patient to see if the treatment is working and if any other treatments are required
72
What is RICE?
- Rest - Ice - Compression - Elevation