Anaesthetics Flashcards
What is Bier’s block?
IV Regional anaesthesia. Local anaesthetic is injected IV into extremities that have been exsanguinated by compression/gravity and torniqued to separate it from central circulation.
Where is local anaesthetic injected in a transversus abdominal plane nerve block?
Between IO and TA
Where is spinal anaesthesia delivered? What does it anaesthetise?
Into the subarachnoid space, L3/L4. Anaesthetises the spinal roots.
What should you do if the patient you have just given spinal anaesthesia develops low BP?
Give crystalloid +/- vasopressors (-> constriction)
What are the signs of total spinal shock?
Low BP, Low HR, anxiety, apnoea, LOC, headache, urinary retention
Where is epidural anaesthesia injected into?
Into the extradural space at L3/L4.
When would a blood patch be necessary in someone who has had a dural puncture?
If headache lasts over 24/48 hours
Where do you inject caudal (sacral epidural)?
Sacral canal
Name 4 absolute contraindications for all neuraxial anaesthesia
1) Anticoagulant states
2) Local sepsis
3) Shock/hypovolaemia
4) High ICP
List 8 premedications
1) Analgesia
2) Anxiolysis (benzos)
3) Amnesia
4) Anti-emesis
5) Antibiotics
6) Anti-autonomic
7) Antacids (e.g. Ranitidine)
8) Steroids
When should antacids be given to a patient who is going to have surgery?
The night before and 2 hours pre-op
Does Propofol have analgesic effects?
NO!
What IV anaesthesia would you give to a trauma patient and why?
Etomidate. Avoidance of hypotension is important (Propofol can cause hypotension)
Where do neuromuscular blockers work?
Post-synaptic receptors at the NMJ
What is suxamethonium?
A partial agonist for acetylcholine receptor - a depolarizing agent
Which muscle relaxant causes initial fasciculations and how? How does this lead to paralysis?
Suxamethonium - It depolarizes post-synaptic membranes and then causes paralysis by inhibiting restoration of normal membrane polarity.
What rapidly inactivates suxamethonium?
Plasma cholinesterases
What is the muscle relaxant of choice in rapid sequence induction?
Suxamethonium
Name 3 side effects of suxamethonium
1) Hyperkalaemia
2) Increased intra-ocular pressure
3) Bradycardia (treat with atropine)
Why does suxamethonium apnoea occur?
When pt is incapable of metabolising suxamethonium quickly enough due to abnormal cholinesterase - they remain paralysed as there is prolonged drug effect for 2 - 24 hrs.
How do non-depolarizing agents work? Do you get fasciculations?
They are competitive antagonists of ACh but without initial depolarisation - so no fasiciculations.
What can be used to reverse non-depolarizing?
Anticholinesterases (e.g. neostigmine)
Name 2 examples of non-depolarizing agents
Rocuronium
Atracurium (for renal and liver failure - Hoffman elimination)
How do patients with Myasthenia Gravis react to muscle relaxants?
They are resistant to suxamethonium BUT v sensitive to non-depolarizing agents so lower doses may be needed.
Name 2 drugs that can be used as co-induction agents in IV induction?
Fentanyl/midazolam